Epidemiological profile of inflammatory bowel disease in Caxias do Sul, Brazil: a cross-sectional study

Dall’Oglio, Vincent Marin; Balbinot, Rafael Sartori; Muscope, Ana Laura Facco; Castel, Mateus Dal; Souza, Thianan Ricardo; Macedo, Renan Souza de; Oliveira, Thanize Barbosa de; Balbinot, Raul Angelo; Brambilla, E; Soldera, Jonathan

doi:10.1590/1516-3180.2020.0179.r2.10092020

Cited by 5 publications

(1 citation statement)

References 15 publications

(18 reference statements)

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“…However, a strong relation between IBD and dysbiosis has been observed since it is common to find the gut microbiome significantly altered in several intestinal diseases. For these reasons, alternative and complementary treatments such as probiotics could help the patient recover [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Effects of probiotics on inflammatory bowel disease: A systematic review

Lopes¹,

Campanari²,

Barbalho³

et al. 2021

Japanese J Gastroenterol Res

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Inflammatory Bowel Disease (IBD) is a chronic idiopathic inflammation of the gastrointestinal tract, characterized by periods of exacerbation and remission, which includes two primary forms: Ulcerative Colitis (UC) and Crohn's Disease (CD). IBD is an autoimmune disorder influenced by genetics, hereditary, environment, and infection. Alternative treatments with fewer side effects have been searched. Thus, the use of probiotics stands out due to several beneficial effects. For this reason, the objective of this systematic review is to evaluate the effects of the use of probiotics in patients diagnosed with IBD. This review included studies available in the MEDLINE databases - PubMed, EMBASE, and Cochrane, and the final selection included thirteen randomized clinical trials. The results showed that the oral use of probiotics and, mainly for a prolonged period, can help in the improvement of reducing symptoms related to IBD. In endoscopic analyzes, a reduction in intestinal inflammation was noted, in addition to a reduction in proinflammatory cytokines. Although there are positive effects, there is a need for further studies to define the best composition of probiotics and time of use since there are many variations in this treatment.

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Section: Introductionmentioning

confidence: 99%

Effects of probiotics on inflammatory bowel disease: A systematic review

Lopes¹,

Campanari²,

Barbalho³

et al. 2021

Japanese J Gastroenterol Res

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Comprehensive analysis of sodium polystyrene sulfonate-induced colitis: A systematic review

Aver,

Ribeiro,

Ballotin

et al. 2023

World J Meta-Anal

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BACKGROUND Sodium polystyrene sulfonate (SPS) is commonly prescribed for the management of hyperkalemia, a critical electrolyte imbalance contributing to over 800000 annual visits to emergency departments. AIM To conduct a systematic review of documented cases of SPS-induced colitis and assess its associated prognosis. METHODS Following the PRISMA-P guidelines, our study employed Medical Subject Headings and Health Sciences Descriptors, skillfully combined using Boolean operators, to conduct comprehensive searches across various electronic databases, including Scopus, Web of Science, MEDLINE (PubMed), BIREME (Biblioteca Regional de Medicina), LILACS (Latin American and Caribbean Health Sciences Literature), SciELO (Scientific Electronic Library Online), Embase, and Opengray.eu. Language criteria were confined to English, Spanish, and Portuguese, with no limitations on the publication date. Additionally, we manually scrutinized the reference lists of retrieved studies. To present our findings, we utilized simple descriptive analysis. RESULTS Our search strategy yielded a total of 442 references. After rigorous evaluation, we included 51 references, encompassing 59 documented cases of colitis. Predominant clinical presentations included abdominal pain, observed in 35 (60.3%) cases, and bloating, reported in 18 (31%) cases. The most frequently affected sites of inflammation were the cecum, rectum, and small intestine, accounting for 31%, 25.8%, and 22.4% of cases, respectively. Colonoscopy findings were described in 28 (48.2%) cases, and 29 (50%) of patients required surgical intervention. Among the subset of patients for whom outcome data was available, 39 (67.2%) experienced favorable outcomes, while 12 (20.6%) unfortunately succumbed to the condition. The mean time required for resolution was 36.7 d, with a range spanning from 1 to 120 d. CONCLUSION SPS demonstrates the capacity to effectively lower serum potassium levels within 24 h. However, this benefit is not without the risk of bowel injury. Our study highlights the absence of high-quality data pertaining to the incidence of adverse events associated with SPS usage, making it challenging to determine whether the potential risks outweigh the benefits. However, a significant mortality rate related to SPS-induced colitis was noted. Future investigations should prioritize randomized controlled trials with a sufficiently large patient cohort to ascertain the true utility and safety profile of this medication.

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