Amount of physical activity necessary for a normal level of high-sensitivity C-reactive protein in ELSA-Brasil: a cross-sectional study

Abstract

Cardiovascular disease is the leading cause of death and disability worldwide and in Brazil. 1,2 Epidemiological studies conducted over the last 50 years have described risk factors for cardiovascular disease and for coronary heart disease, such as dyslipidemia, hypertension, smoking and diabetes. 3 Moreover, new risk markers such as high-sensitivity C-reactive protein (hs-CRP) levels have been highlighted over recent years as potential predictors of cardiovascular risk. 4,5 hs-CRP is an acute-phase protein produced in the liver through the primary stimulus of the interleukins IL-1 and IL-6. It has also been assumed that hs-CRP can be produced from the arterial wall. hs-CRP is an extremely sensitive marker for inflammation and tissue damage. 6 Recently, chronic inflammation has been identified as a component in the development and progression of atherosclerosis. 7-9 The association between regular physical activity and cardiovascular risk factors, 10,11 including hs-CRP, 12,13 has been the subject of evaluations. The MONICA (Multinational Monitoring of trends and determinants in Cardiovascular disease) study in Augsburg, Germany, among men and women aged 35 to 74 years, investigated the association between different domains of physical activity (leisure-time, work, domestic and commuting domains) and markers for inflammation (fibrinogen, hs-CRP and IL-6). An inverse association was found between total physical activity and hs-CRP, even after adjusting for potential confounders. 14,15 Other studies have shown similar results, i.e. indicating significant reduction of hs-CRP levels when moderate exercise is performed. 16,17 Physical activity is defined as any bodily movement produced by skeletal muscles that results in energy expenditure above resting levels. It may occur within the domains of leisure time, commuting, household or occupational activities. 18 The amount of physical activity that is required

C-Reactive Protein Based on Injury Level and Physical Activity Level of Chronic Spinal Cord Injury Patient

“…Several studies have shown that physical activity reduces CRP levels (Plaisance et al, 2006;Morse et al, 2008;Majka et al, 2009). Physical activity can reduce the number of proinflammatory cytokines (IL-1, IL6 and TNF ) and reduce the production of CRP from the liver (Queiroz et al, 2020).…”

“…Physical exercise can reduce inflammatory markers by reducing cytokine release and also increasing antioxidant status (Hopps et al, 2011). Physical activity can reduce proinflammatory cytokines and then reduce CRP (Queiroz et al, 2020). At SCI levels C3-T6 where there was an increase in proinflammatory cytokines, the group that had a significantly active level of physical activity had better CRP levels than the less active group.…”

Physical activity and sedentary behavior as multimorbidity discriminators among elderly Brazilians: a cross-sectional study

“…15,16 In previous studies, some cutoff points for physical activity and sedentary behavior for disease prediction were proposed, and questionnaires were used to measure these behaviors. 17 Subjective measurements may underestimate the accumulated time spent on sedentary behavior and overestimate the time spent on physical activity among older people, even though such measurements are easy to apply and have low cost.…”

“… 15 , 16 In previous studies, some cutoff points for physical activity and sedentary behavior for disease prediction were proposed, and questionnaires were used to measure these behaviors. 17 Subjective measurements may underestimate the accumulated time spent on sedentary behavior and overestimate the time spent on physical activity among older people, even though such measurements are easy to apply and have low cost. However, objective tools such as accelerometers provide reliable and valid physical activity measurements that make it possible to more faithfully capture different intensities of movement (sedentary, light, moderate and vigorous).…”