What do Cochrane systematic reviews say about the management of irritable bowel syndrome?

Pacheco, Rafael Leite; Roizenblatt, Arnaldo; Góis, Aécio Flávio Teixeira de; Latorraca, Carolina de Oliveira Cruz; Pimentel, Carolina Frade Magalhães Girardin; Riera, Rachel

doi:10.1590/1516-3180.2018.053740119

Cited by 7 publications

(5 citation statements)

References 25 publications

(57 reference statements)

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“…The commonly used IBS treatments, ranging from dietary exclusion to psychoactive medications, are relatively ineffective and their variety reflects the uncertain etiology 6 . Behavioral therapies, while more effective (number needed to treat = 4), are not widely available 7 .…”

Section: Mainmentioning

confidence: 99%

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Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

et al. 2021

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Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain–gut interactions underlying IBS.

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Section: Mainmentioning

confidence: 99%

“…School of biological Sciences, monash University, Clayton, Victoria, Australia 5. IbD Pharmacogenetics, College of medicine and Health, University of exeter, exeter, UK 6. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK 7.…”

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confidence: 99%

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

et al. 2021

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“…Although there is no known definitive treatment for IBS, it is essential to determine the prevalence of IBS and associated risk factors for raising awareness and taking preventive measures such as dietary regulations and various psychological interventions [5]. It might be considered that medical students experience more stress than other students because of the long educational process, long working hours, difficult exams, and challenges associated with dealing with patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of irritable bowel syndrome and associated factors in intern doctors at a state university in western black sea, Turkey: A cross-sectional study

Sargin¹,

Ceylan²

2022

Med-Science

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Irritable bowel syndrome (IBS) is a functional digestive disorder that affects medical students at a higher rate than the general population. Intern doctors are the most affected class by IBS among medical students. Determining the prevalence of IBS and associated risk factors is essential for taking preventive measures. We aimed to investigate the prevalence and predictors of IBS among intern doctors in this study. This study was conducted using an online survey for intern doctors in the 2021-2022 academic year. Rome IV criteria were utilized for IBS diagnosis. Anxiety and depression scores were calculated according to the Hospital Anxiety and Depression Scale (HADS). The prevalence of IBS in the 249 participants was 31.7% included in this study. 32.1% of all participants had depression, 44.2% had anxiety, 65.1% had sleep disorders, 73.1% had MSE (medical specialty exam) anxiety, and 96% were concerned about carrying out the medical profession after graduating from university. Female gender (p<0.001), using regular medication (p=0.019), not exercising regularly (p=0.002), sleep disturbance (p<0.001), food hypersensitivity (p=0.001), having a history of severe acute gastroenteritis (AGE) before IBS symptoms started (p<0.001), IBS in first-degree relatives (p<0.001), be low income (p<0.001), having a divorced parent (p=0.008), not having siblings (p=0.002), severe emotional stress history in the last six months (p=0.004), having depression (p<0.001), having anxiety (p<0.001), and MSE anxiety (p<0.001) identified as risk factors associated with IBS. The multivariant analysis determined independent risk factors affecting the prevalence of IBS in intern doctors as female gender, depression, anxiety, and severe AGE history before IBS symptoms started. In this study, it was determined that approximately one-third of the interns were diagnosed with IBS. Stress management training can be considered to screen this group for IBS and psychological problems and to help them cope with these stressors.

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Section: Introductionmentioning

confidence: 99%

Lower back pain in patients applying to family health center

Gözükara¹,

Gözükara²,

Turan³

2022

Med-Science

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Lower back pain is a musculoskeletal system problem with a high prevalence, causing disability and adversely affecting the domestic economy. To decrease the prevalence and morbidity of lower back pain, individual, psycho-social, and vocational risk factors should be identified properly. Our research aims to assess the lower back prevalence in primary healthcare services, risk factors, and knowledge and behaviors to prevent lower back pain. Our research is a cross-sectional study that uses face-to-face surveys with individuals who visited the family healthcare centers in Mersin for any reason and consented to participate in our study. The average age of 217 patients is (18-80). 54.4% of the participants are female, while 45.6% of them are male. 83.8% stated that they have experienced lower back pain at least once in their lifetime and 76.3% of these participants reported that they have had lower back pain in the last year. 41.9% of the participants defined themselves as happy, whereas those who had lifelong lower back pain were more likely to define themselves as unhappy/neither happy nor unhappy (p:0.013). Lifelong low back pain was found to be significantly higher in those who did not exercise (p:0.014). It is found that it is higher for those who have advanced age, do not consider themselves happy, do not exercise, and cannot receive support from their supervisors. In-service training should be provided.

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What do Cochrane systematic reviews say about the management of irritable bowel syndrome?

Cited by 7 publications

References 25 publications

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Prevalence of irritable bowel syndrome and associated factors in intern doctors at a state university in western black sea, Turkey: A cross-sectional study

Lower back pain in patients applying to family health center

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