Depression and anxiety among patients undergoing dialysis and kidney transplantation: a cross-sectional study

Abstract

Despite advancements in renal replacement therapies and increased survival, patients still face several physical, psychological and social limitations as consequences of chronic kidney disease and treatment complexity. 1,2 The daily struggle with end-stage renal disease symptoms and related comorbidities, along with the need to cope with psychosocial stressors, directly impacts patients' quality of life and mental health. 3,4 Depression and anxiety are considered to be the most common end-stage renal disease-related psychological disorders, with higher prevalence and incidence rates in this population than those in the general population. 5-10 According to the World Health Organization, the estimated global prevalence rates of depression and anxiety in 2015 were 4.4% and 3.6%, respectively, with an increase in reported cases of 18% between 2005 and 2015. 11 The anxiety and depression rates that have been estimated among end-stage renal disease patients are not accurate: they range from 0 to 100%, depending on the diagnostic criteria, assessment tool and population characteristics. 12 A systematic review of 55 studies revealed prevalence rates of 38% and 27% for anxiety and depression, respectively, among end-stage renal disease patients. 13 The high frequency and impact of affective symptoms in nephrology practice have led the research community to devote increasing attention to depression and anxiety over the last few years. 7 In end-stage renal disease, these mental disorders are associated with various conditions that lead to poorer health outcomes, with direct impacts on patients' quality of life and survival. 14-23 Anxiety and depression are also associated with unhealthy forms of behavior, such as alcohol and tobacco use, poor eating habits, sedentary lifestyle and non-compliance with treatment. 24 These factors translate into increased risks of clinical events and the need for emergency services, thus resulting in higher healthcare costs. 25-26

Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

“…Oyekçin et al [141], in their small study group, found that depression and anxiety were more prevalent in HD than PD and control, and that chronic dialysis disturbed body image and decreased sexual satisfaction. Other recent studies also found that HD patients were more depressed and anxious than patients after RT [142][143][144]. In contrast, Peng et al found no difference in HRQOL between HD and PD patients in a large comparative study in Taiwan [145], and in a similar study of a Taiwanese cohort by Mau et al, only the subscales evaluating bodily pain and social functioning significantly differed between HD and PD patients [146].…”

Does Depression and Anxiety Mediate the Relation between Limited Health Literacy and Diet Non-Adherence?

“…Depression and anxiety are common in dialyzed patients [11][12][13][14]. The prevalence ranges from about 12 to 52% for anxiety and from about 23 to 42% for depression [15][16][17], among others depending on the assessment tools used. Depression and anxiety are both associated with impaired quality of life in dialyzed patients [18][19][20], and with worse health outcomes and increased mortality [21][22][23][24][25][26][27][28].…”

Prevalence and risk factors associated with Anxiety Symptoms and Disorders Among Chronic Kidney Disease patients – A Systematic Review and Meta-analysis of studies

“…Of the psychosocial-related risk factors in Table 2, poorer perceived quality of life (8, 10, 32, 35, 53, 54, 57, 67) was the most studied risk factors associated with anxiety. Increased negative emotions (48) and family problems (65) as well as reduced self-efficacy (64), vitality (34, 79) and social functioning (79) were associated with increased anxiety.…”