Analysis on the risk factors for organ damage in patients with systemic lupus erythematosus: a cross-sectional single-center experience

Živković, Vesna; Mitić, Branka; Stamenković, Bojana; Stojanović, Simona; Dinić, B; Stojanović, Miodrag; Jurišić, Vladimir

doi:10.1590/1516-3180.2018.0258060219

Cited by 8 publications

(1 citation statement)

References 28 publications

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“…Thus, it has been recommended that of corticosteroids, it should be as low as possible. The same was seen in relation to mycophenolate mofetil and pulse of cyclophosphamide [48]. Given that unlike what is seen in CLASI activity score, no difference was found between SLE patients with plasmaand urine-positive Wnt5A and urine-negative Wnt5A protein (Table 1).…”

Section: Discussionmentioning

confidence: 56%

Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion severity in patients with systemic lupus erythematosus

et al. 2021

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Reliable noninvasive biomarkers are needed to accurately assess disease activity and prognosis in patients with systemic lupus erythematosus (SLE). The purpose of this study was to investigate the clinical relevance of Wnt5A with disease activity and severity with cutaneous involvement in particular in SLE patients; its concentrations in plasma and urine were examined and analyzed. In the cross-sectional study, the clinical relevance of Wnt5A protein was evaluated in both plasma and urine of SLE patients and healthy cohorts using commercial enzyme-linked immunosorbent assays (ELISA). Significantly, more abundances of Wnt5A protein were determined in both of plasmas and urines of SLE patients compared to healthy cohorts (p < 0.0001), which were even higher in active disease (AD) SLE patients relative to low disease activity (LDA) SLE patients (p < 0.0001). Meanwhile, the ROC curve analysis demonstrated that the plasma and urine Wnt5A were potential candidate biomarkers for identifying the disease activity and severity in SLE patients. The discriminant function analysis further revealed that the plasma and urine Wnt5A were separated and distinct for AD SLE patients and healthy controls. In consistence, the disease severity was correlated with the plasma and urine Wnt5A as ascertained by CLASI activity score and the prevalence of serositis in SLE patients. These results suggest that Wnt5A, as a summary measure for different inflammatory processes, could be a potential biomarker for accessing the disease activity, and a noninvasive biomarker for evaluating the disease severity in terms of cutaneous involvement in SLE patients.

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Section: Discussionmentioning

confidence: 56%

Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion severity in patients with systemic lupus erythematosus

et al. 2021

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Predictors of Organ Damage in Systemic Lupus Erythematosus in the Asia Pacific Region: A Systematic Review

Ramnarain,

Liam,

Milea

et al. 2024

Arthritis Care & Research

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ObjectivesIrreversible organ damage is common in patients with systemic lupus erythematosus (SLE). Despite evidence of increased prevalence and severity of SLE in Asia Pacific, organ damage is less well studied in this region. This systematic review aims to identify predictors of organ damage in SLE in the Asia Pacific region.MethodsWe searched Medline, PubMed, Embase and Web of Science for observational studies on organ damage in adult SLE patients in Asia Pacific from August 31st ‐ September 5th 2022. Study selection and data extraction was completed by two independent reviewers using Covidence systematic review software. Risk of bias was assessed using the Newcastle‐Ottawa Scale and Joanna‐Briggs Institute tool. Significant results from univariable and multivariable analyses were synthesized from included studies.ResultsThirty‐eight eligible studies were selected from 1999 – 2022; 22 (58%) of these reported organ damage at study enrolment and 19 (50%) reported damage accrual, as measured by the Systemic Lupus International Collaborating Clinic/American College of Rheumatology Damage Index. Factors predictive of organ damage included older age, glucocorticoid use, longer disease duration and disease activity. Lupus nephritis was a risk factor for renal and overall damage accrual. Hydroxychloroquine was protective against overall organ damage.ConclusionPredictors of organ damage in SLE in Asia Pacific are similar to other regions. Whilst glucocorticoid use is a modifiable risk factor for organ damage, the impact of immunosuppressives and biological therapies needs further investigation. Effective strategies in early disease are needed to minimise initial organ damage as it predicts subsequent damage accrual.

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Relationship between disease activity, organ damage and health-related quality of life in patients with systemic lupus erythematosus: A systemic review and meta-analysis

Shi¹,

Li²,

Liu³

et al. 2021

Autoimmunity Reviews

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Analysis on the risk factors for organ damage in patients with systemic lupus erythematosus: a cross-sectional single-center experience

Cited by 8 publications

References 28 publications

Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion severity in patients with systemic lupus erythematosus

Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion severity in patients with systemic lupus erythematosus

Predictors of Organ Damage in Systemic Lupus Erythematosus in the Asia Pacific Region: A Systematic Review

Relationship between disease activity, organ damage and health-related quality of life in patients with systemic lupus erythematosus: A systemic review and meta-analysis

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