Association of alanine aminotransferase concentration with cardiometabolic risk factors in children and adolescents: the CASPIAN-V cross-sectional study

Abstract

BACKGROUND: It has been suggested that the levels of some liver enzymes, and especially alanine aminotransferase (ALT), might be correlatable with cardiometabolic risk factors. We investigated the relationship between ALT concentration and cardiometabolic risk factors among children and adolescents. DESIGN AND SETTING: This nationwide study in Iran was conducted within the framework of the fifth survey of a national surveillance program known as the Childhood and Adolescence Surveillance and PreventIon of Adult Non-communicable disease study (CASPIAN-V). METHODS: The participants comprised 4200 students aged 7-18 years, who were recruited through multi-stage random cluster sampling in 30 provinces in Iran. Physical examinations and laboratory tests were conducted in accordance with standard protocols. RESULTS: Overall, 3843 students (participation rate: 91.5%) completed the survey. Mean ALT levels were significantly higher in individuals with dyslipidemia, in terms of elevated total cholesterol (TC) or LDL-cholesterol or triglycerides (TG), excess weight and dyslipidemia. Some cardiometabolic risk factors were associated with higher levels of ALT, with the following odds ratio (OR) and 95% confidence interval (CI): metabolic syndrome (OR: 1.013; 95%

Genetic Variants and Haplotypes in OPG Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study

“…Furthermore, rs3134069, rs3134070, and rs3102735 have been associated with decreased levels of gamma glutamyl transpeptidase and alanine aminotransferase, and high levels of liver enzymes have been considered a risk factor for developing cardiovascular disease and even as a cause of cardiovascular mortality (Kelishadi et al, 2018;Ndrepepa et al, 2018;Chung et al, 2019;Ma et al, 2019;Rahmani et al, 2019;Jeon et al, 2020). On the other hand, we observed that rs3134069, rs3134070, and rs3102735 were associated with an increased risk of T2DM; this outcome was opposite to what we expected.…”

The association between metabolic syndrome and elevated serum alanine transaminase levels in an indigenous population in Northern Taiwan: a community-based study

“…In addition, a Korean study also con rmed that serum ALT levels were positively associated with MetS and its components (FPG, TGs, BP, and WC) [11], and we also found weak positive linear relationships between serum ALT levels and cardiometabolic risk factors (BMI, SBP, DBP, WC, FPG, HS-CRP) in our study. Although the present study only included adults aged over 18, a nationwide study conducted in Iran indicated that MetS and some cardiometabolic risk factors were signi cantly associated with ALT levels in children and adolescents aged 7-18 years [30].…”

Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease

“…Risk allele participants showed a higher risk for excessive liver fat deposition. Recent studies have indicated that higher levels of abdominal fat, particularly visceral fat, are closely related to NAFLD [60]. In addition, higher visceral fat content was observed in the risk allele group as compared with the other.…”