What do Cochrane systematic reviews say about probiotics as preventive interventions?

Braga, Vinícius Lopes; Rocha, Luana Pompeu dos Santos; Bernardo, Daniel Damasceno; Cruz, Carolina de Oliveira; Riera, Rachel

doi:10.1590/1516-3180.2017.0310241017

Cited by 15 publications

(10 citation statements)

References 27 publications

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“…There were 20 studies out of 2,751 conducted showed that probiotics decrease the duration of diarrhea to 4 days and decrease its frequency on day 2 [12]. In our study this is not the case.…”

Section: Discussioncontrasting

confidence: 69%

Comparative Study for Probiotics and Symbiotics Versus Placebo in Pediatrics Acute Diarrhea: Randomized Controlled Trial

et al. 2018

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Background: Acute diarrhea is a major cause of morbidity and mortality in children, particularly in developing countries (the second cause of death). Probiotics and symbiotics are recent treatments for this disease, especially in the acute phase. Our objective is to compare probiotic or symbiotic treatment against placebo in acute diarrhea by following the evolution of diarrhea in terms of hours, number of bowel movements, volume of stools and their consistency. On a larger scale, we want to find a cost-effective intervention that reduces the morbidity and mortality of diarrhea. Methods: Eighty-three children aged 6 months to 5 years, from three different regions of Mount Lebanon, were randomized to receive a probiotic, a symbiotic or a placebo once daily for 5 days. Patients were excluded from the study if they had any history of a chronic disease. The statistical analysis was carried out on SPSS v22.00 Results: Out of 120 surveys distributed to parents, 84 were completed: 43 patients received probiotics (nine received Lactobacillus, 21 received spores, and 13 patients received yeast), 24 received symbiotics and 17 were controls. Stool consistency normalized on day 4 in the probiotics and symbiotics groups (P = 0.009). Less number of days with fever (P = 0.018) were observed in the probiotic and symbiotic groups (1 day) compared to placebo (4 days). No difference in the symptoms associated with diarrhea was observed in the different groups. Conclusions: Probiotics and symbiotics normalized stool consistency in pediatric diarrhea by day 4 and decreased the number of days with fever compared to control. Our study did not show a statistically significant difference between the different probiotics and symbiotics for the treatment of diarrhea.

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Section: Discussioncontrasting

confidence: 69%

Comparative Study for Probiotics and Symbiotics Versus Placebo in Pediatrics Acute Diarrhea: Randomized Controlled Trial

et al. 2018

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“…An analysis including 16 Cochrane reviews that evaluated the potential preventative effects of different probiotics reported a decreased incidence of antibiotic-associated diarrhea and CDI related to probiotic use, but, given the low quality of the evidence, the authors suggested that further trials should be conducted. 168 Several reports evaluating specific strains or combinations of probiotics including Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Saccharomyces boulardii reached conflicting conclusions and do not support a particular probiotic regimen. 164,169,170 Despite extensive analyses regarding probiotics, questions regarding efficacy, the optimal agent(s), length of therapy, and dosing remain unanswered.…”

Section: Oral Vancomycin or Fidaxomicin Is Considered Firstline Treat...mentioning

confidence: 99%

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Clostridioides difficile Infection

Poylin

Hawkins

Bhama

et al. 2021

Diseases of the Colon &Amp; Rectum

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“…Additional meta-analyses have been conducted in order to determine if probiotic efficacy is strain-and diseasedependent [22]. There is strong evidence that probiotics are strain-specific in mitigating symptoms associated with individual diseases [23]. When evaluating a probiotic supplement, the specific strain, the disease, and the individual should be considered, as should results of well-designed human clinical trials.…”

Section: Probioticsmentioning

confidence: 99%

Probiotics, Nutrition, and the Small Intestine

Judkins

Archer

Kramer

et al. 2020

Curr Gastroenterol Rep

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Purpose of Review Probiotics are promising remedial treatments for symptoms of small intestine (SI) diseases and promoters of overall good health. Probiotics play an important role in supporting a healthy SI microbiome (eubiosis), and in preventing establishment of unhealthy microbiota. SI eubiosis promotes optimal nutrient uptake, and optimal nutritional status maintains a healthy SI, reducing the likelihood of SI diseases. It is important to understand the advantages and limitations of probiotic therapies. Recent Findings Microbial dysbiosis decreases the capacity of the small bowel to utilize and absorb dietary compounds. In some studies, probiotic supplements containing lactic acid bacteria and Bifidobacterium have been demonstrated effective in supporting beneficial microbes in the SI while improving barrier integrity and reducing nutrient malabsorption and SI disease-related pathology. Summary Strain-specific probiotic therapy may be a natural and effective approach to restoring SI barrier integrity and eubiosis, resulting in improved nutrient absorption and better health, including reducing the incidence of and severity of SI diseases.

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What do Cochrane systematic reviews say about probiotics as preventive interventions?

Cited by 15 publications

References 27 publications

Comparative Study for Probiotics and Symbiotics Versus Placebo in Pediatrics Acute Diarrhea: Randomized Controlled Trial

Comparative Study for Probiotics and Symbiotics Versus Placebo in Pediatrics Acute Diarrhea: Randomized Controlled Trial

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Clostridioides difficile Infection

Probiotics, Nutrition, and the Small Intestine

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