Survival outcome among patients with Ewing’s sarcoma of bones and joints: a population-based cohort study

Wan, Zhongmin; Huang, Zhihao; Chen, Liaobin

doi:10.1590/1516-3180.2017.0236230917

Cited by 23 publications

(32 citation statements)

References 30 publications

(27 reference statements)

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“…Large national databases and international collaborations are essential tools for studying epidemiology, outcomes, and trends in order to develop treatment guidelines and guide future research. Oncology registries such as SEER provide excellent data on long-term prognosis and survival trends but fail to capture short-term treatment specific morbidity [13][14][15][16][17][18][19][20]. NSQIP-P is a large, national registry capturing patient demographics, comorbidities, and perioperative complications, making it an ideal tool to study patient characteristics and short-term outcomes after surgical management of sarcomas.…”

Section: Discussionmentioning

confidence: 99%

“…ese data are essential for determining the efficacy of treatment protocols and the incidence of long-term sequelae. However, a frequently cited limitation of SEER and other long-range studies is the lack of data on patient comorbidities and postoperative complications [13][14][15][16][17][18][19][20]. Understanding of treatment specific morbidity is an essential component of preoperative planning.…”

Section: Introductionmentioning

confidence: 99%

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Thirty-Day Outcomes following Pediatric Bone and Soft Tissue Sarcoma Surgery: A NSQIP Pediatrics Analysis

Gallaway

Ahn

Callan

2020

Sarcoma

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Background. Pediatric bone and soft tissue sarcomas are rare; therefore, national registries are essential tools for orthopedic oncology research. Past studies provide excellent data on long-term prognosis and survival trends but fail to examine treatment-specific morbidity. The aim of this study is to use a national registry to describe patient demographics, comorbidities, and adverse events in the first thirty days following surgical management of pediatric bone and soft tissue sarcomas. Methods. A retrospective review of patients in the American College of Surgeons National Surgical Quality Improvement Program—Pediatrics database (NSQIP-P) was performed. The cohort was partitioned by tumor origin (bone versus soft tissue) and tumor location (axial versus appendicular). Results. One-hundred ninety-two patients were identified. Bone sarcomas were more common (71.9%) and predominately appendicular (62.3%), while soft tissue sarcomas were predominately axial (77.8%). The overall complication rate was 8.9%. The most frequent etiologies were wound dehiscence (3.6%) and infectious complications such as surgical site infections (2.6%), pneumonia (1.6%), urinary tract infections (1.6%), and C. diff colitis (1.0%). Twenty-four percent of patients experienced bleeding requiring transfusion. The unplanned readmission rate was 12.5% (3.6% related to principle procedure), and the unplanned reoperation rate was 4.7% (4.2% related to principle procedure). The mortality rate was 1.0%. Neoadjuvant chemotherapy was associated with higher rates of wound dehiscence and infectious complications. There were no differences in adverse events with respect to tumor origin or location. Conclusion. Approximately 1 in 11 pediatric patients will experience a complication in the first thirty days following surgery. However, perioperative mortality remains low. This study represents the first comprehensive review of pediatric bone and soft tissue sarcoma surgery in the NSQIP-P database. As the case volume of NSQIP-P continues to grow, NSQIP-P has the potential to become a powerful tool for pediatric orthopedic oncology research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thirty-Day Outcomes following Pediatric Bone and Soft Tissue Sarcoma Surgery: A NSQIP Pediatrics Analysis

Gallaway

Ahn

Callan

2020

Sarcoma

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“…In previous studies, the effect of tumor size on survival was inconsistent. Most of these studies believed that larger tumors size was harmful to patient survival [ 24 – 27 ]. In contrast, other studies supported that tumor size had no influence on the survival [ 28 – 30 ].…”

Section: Discussionmentioning

confidence: 99%

Nomograms Predict Overall Survival and Cancer-Speciﬁc Survival in Patients with Fibrosarcoma: A SEER-Based Study

Xiang

Zhu

et al. 2020

Journal of Oncology

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Purpose. Due to the rarity, it is difficult to predict the survival of patients with fibrosarcoma. This study aimed to apply a nomogram to predict survival outcomes in patients with fibrosarcoma. Methods. A total of 2235 patients with diagnoses of fibrosarcoma were registered in the Surveillance, Epidemiology, and End Results database, of whom 663 patients were eventually enrolled. Univariate and multivariate Cox analyses were used to identify independent prognostic factors. Nomograms were constructed to predict 3-year and 5‐year overall survival and cancer‐specific survival of patients with fibrosarcoma. Results. In univariate and multivariate analyses of OS, age, sex, race, tumor stage, pathologic grade, use of surgery, and tumor size were identiﬁed as independent prognostic factors. Age, sex, tumor stage, pathologic grade, use of surgery, and tumor size were significantly associated with CSS. These characteristics were further included to establish the nomogram for predicting 3-year and 5-year OS and CSS. For the internal validation of the nomogram predictions of OS and CSS, the C-indices were 0.784 and 0.801. Conclusion. We developed the nomograms that estimated 3-year and 5-year OS and CSS. These nomograms not only have good discrimination performance and calibration but also provide patients with better clinical benefits.

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“…ese studies focus on epidemiology, tumor recurrence, diseasespecific survival, outcomes essential for evaluating treatment protocols, and identifying long-term sequalae. However, oncology databases such as SEER fail to adequately capture patient comorbidities and early postoperative complications [11][12][13]. Early complications of surgery can delay adjuvant therapy, potentially affecting long-term oncologic outcomes [14].…”

Section: Introductionmentioning

confidence: 99%

Thirty-Day Outcomes after Surgery for Primary Sarcomas of the Extremities: An Analysis of the NSQIP Database

Gallaway

Ahn

Callan

2020

Journal of Oncology

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Background. Primary bone and soft tissue sarcomas are rare tumors requiring wide surgical resection and reconstruction to achieve local control. Postoperative complications can lead to delays in adjuvant therapy, potentially affecting long-term oncologic outcomes. Understanding postoperative complication risks is essential; however, past studies are limited by small sample sizes. Purpose. This study uses a large national registry to characterize the incidence of complications and mortality in the first thirty days following surgical management of primary bone and soft tissue sarcomas of the extremities. Methods. A retrospective review of patients in the National Surgical Quality Improvement Program database was performed. Cases were identified using diagnosis codes for malignant neoplasm of soft tissue or bone and procedure codes for amputation and radical resection. The cohort was subdivided by bone versus soft tissue sarcoma, upper versus lower extremity, and amputation versus limb salvage. Results. One thousand, one hundred eleven patients were identified. The most frequent complications were surgical site infections, sepsis, and venous thromboembolism. The overall incidence of complications was 14.0%. Unplanned readmission and reoperation occurred after 7.0% and 8.0% of cases, respectively. Thirty-day mortality was 0.3%, with one intraoperative death. Patient factors and complication rates varied by tumor location and surgical modality. Lower extremity cases were associated with higher rates of wound complications and infectious etiologies such as surgical site infections, urinary tract infections, and systemic sepsis. In contrast, patients undergoing amputation were more likely to experience major medical complications including acute renal failure, cardiac arrest, and myocardial infarction. Conclusion. Approximately 1 in 7 patients will experience a complication in the first thirty days following surgery for primary bone and soft tissue sarcomas of the extremities. The unique risk profiles of lower extremity and amputation cases should be considered during perioperative planning and surveillance.

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Survival outcome among patients with Ewing’s sarcoma of bones and joints: a population-based cohort study

Cited by 23 publications

References 30 publications

Thirty-Day Outcomes following Pediatric Bone and Soft Tissue Sarcoma Surgery: A NSQIP Pediatrics Analysis

Thirty-Day Outcomes following Pediatric Bone and Soft Tissue Sarcoma Surgery: A NSQIP Pediatrics Analysis

Nomograms Predict Overall Survival and Cancer-Speciﬁc Survival in Patients with Fibrosarcoma: A SEER-Based Study

Thirty-Day Outcomes after Surgery for Primary Sarcomas of the Extremities: An Analysis of the NSQIP Database

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