Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Posselt, Rayana Taques; Coelho, Vinícius N.; Pigozzo, Danieli Cristina; Guerrer, Marcela Idalia; Fagundes, Marília Da Cruz; Nisihara, Renato; Skare, Thelma Larocca

doi:10.1590/1516-3180.2017.0089110617

Cited by 9 publications

(3 citation statements)

References 43 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, while the anti-microsomal antibody positivity rate in MS patients was found to be 11.6%, the antithyroglobulin antibody frequency was detected to be 13.6%, and none of the patients had hypothyroidism. In a study performed by Posselt et al, it was found out that the rate of antithyroglobulin antibody positivity was 4.9% without hypothyroidism in healthy controls, that this rate was much higher in patients with rheumatic disease, and that the highest rate was observed in SLE patients (16). Based on the data of our study, it can be said that the positivity of thyroid autoantibodies is higher compared to the normal population in MS disease like in the other autoimmune diseases.…”

Section: Discussionsupporting

confidence: 58%

Evaluation of autoantibody positive in multiple sclerosis patients

Gökçe¹,

Çiğdem²

2019

Cumhuriyet Medical Journal

View full text Add to dashboard Cite

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system in which impaired immune activation is involved. It is known that other autoimmune diseases are seen more frequently in MS patients. Many rheumatologic diseases could cause neurologic disorders that mimic MS. Our aim in this study is to determine the rates of autoantibody positivity and the clinical significance of these positivity rates in patients with MS. Method: 110 patients who were followed up with MS diagnosis in our clinic between 2008 and 2018 were retrospectively evaluated for autoimmune disease biomarkers. The diagnosis of MS was confirmed using both 2005 and 2010 Revised Mc Donald Criteria. Results: The ANA (antinuclear antibody) positivity rate in our patients was 10.9%, the ANA profile positivity was 9.1%. Anti-ds DNA (double stranded deoxyribonucleic acid) positivity rate was 1.8%, anti-cardiolipin Ig (immunglobulin) G and Ig M were 0.9% positive. Anti-microsomal antibody positivity was 11.8% while antithyroglobulin antibody was positively 13.6%. The value of complement 3 (C3) was found to be 92.7% normal and 4.5% higher and 2.7% lower, respectively. The C4 values were 98.2% normal, while they were 11.8% higher than normal. Six patients had six different diseases in which ethiopathogenesis the role of autoimmunity was also revealed (ankylosing spondylitis, psoriasis, systemic lupus erythematosus, morfea, ptriyazis, Sjögren's syndrome). Conclusions: Although some autoantibody positivities in MS patients are more frequent than healthy controls, these positivities are not usually associated with systemic rheumatologic disease and haven't clinical significance. Therefore, the evaluation of autoantibodies in each MS patient does not seem cost effective. So, the MS patients whose autoantibody levels are to be measured should be well selected before the evaluation the patients' medical history and complaints should be taken into consideration.

show abstract

Section: Discussionsupporting

confidence: 58%

Evaluation of autoantibody positive in multiple sclerosis patients

Gökçe¹,

Çiğdem²

2019

Cumhuriyet Medical Journal

View full text Add to dashboard Cite

show abstract

“…Patient with SLE are more prone to thyroid problems compared to the controls and is usually more so in those having overlap syndrome [4,5]. They can have positive thyroid antibodies with or without overt thyroid manifestations [6]. it predominantly manifests in patients with SLE and Hashimoto's during the hypothyroid state rather than hyperthyroid, suggesting that the initial hyperthyroid state could be obscured [7].…”

Section: Discussionmentioning

confidence: 99%

Association of Autoimmune Hashimoto's Thyroiditis with Systemic Lupus Erythematosis

Kammari

Daggubati²,

Konala

et al. 2020

Cureus

View full text Add to dashboard Cite

SLE (systemic lupus erythematosus) can be associated with other autoimmune disorders with overlapping clinical symptoms. We present a case of a 22-year-old male with recurring exertional dyspnea, chest pain, dry cough and chills, which on further testing revealed large pericardial effusion and bilateral pleural effusions along with laboratory abnormalities consistent with a diagnosis of overlap of SLE with serositis and Hashimoto's thyroiditis. SLE patients with underlying hypothyroidism are slow to respond to standard therapy unless the underlying hypothyroidism is adequately treated.

show abstract

“…These antibodies are not specific to GD and may be detected in other autoimmune endocrine illnesses as well. 21 Thyroid ultrasonography is not required to establish the diagnosis of GD; however, it does provide a precise estimate of thyroid size, which is useful in treatment planning. It exhibits hypervascularized thyroid parenchyma that is either normal or hypoechogenic.…”

Section: Diagnosismentioning

confidence: 99%

Graves’ Disease in Children: An Update

Metwalley

Farghaly

2023

Clin Med Insights Endocrinol Diabetes

View full text Add to dashboard Cite

Graves’ disease (GD) is the most common cause of hyperthyroidism in children. A common GD symptom is a goiter. The usual biochemical profile in children with GD is a decreased thyroid hormone stimulating hormone (TSH) level and high free thyroxine (FT4) and free triiodothyronine (FT3) concentrations. The presence of thyroid receptor antibodies (TRAb) is the most important specific immunological sign for diagnosing GD. The treatment choices for pediatric GD are anti-thyroid drugs (ATDs), radioiodine, and thyroidectomy, but the risks and benefits of each modality are different. Management recommendations include the first-line use of a prolonged course of ATDs for at least 3 years and potentially 5 years or more. Rituximab and Teprotumumab are new novel alternative medications for the treatment of adult patients with GD and Graves’ orbitopathy respectively, but evidence of the efficacy and safety of these drugs in pediatric patients with GD is lacking.

show abstract

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Cited by 9 publications

References 43 publications

Evaluation of autoantibody positive in multiple sclerosis patients

Evaluation of autoantibody positive in multiple sclerosis patients

Association of Autoimmune Hashimoto's Thyroiditis with Systemic Lupus Erythematosis

Graves’ Disease in Children: An Update

Contact Info

Product

Resources

About