Accuracy of spirometry for detection of asthma: a cross-sectional study

Meneghini, Andrea; Paulino, Ana Carolina Botto; Pereira, Luciano Penha; Vianna, Elcio Oliveira

doi:10.1590/1516-3180.2017.0041250517

Cited by 7 publications

(6 citation statements)

References 17 publications

(29 reference statements)

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“…Logistic regression analyses showed good ICS adherence was associated with perception of asthma as an illness with a longer timeline (OR=1.22; 95% CI=1.10-1. 35…”

Section: Results Of Logistic Regressionmentioning

confidence: 99%

“…However, evidence also suggested that spirometry is not a sensitive tool to diagnose asthma and patients with asthma may demonstrate normal spirometry. 35,36 Implications for Research and/or Practice The results showed the magnitude of poor ICS adherence among older patients with asthma. This should prompt review of the asthma counselling program.…”

Section: Strengths and Limitationsmentioning

confidence: 95%

“…However, evidence also suggested that spirometry is not a sensitive tool to diagnose asthma and patients with asthma may demonstrate normal spirometry. 35 , 36…”

Section: Strengths and Limitationsmentioning

confidence: 99%

See 2 more Smart Citations

<p>The Association Between Beliefs and Adherence to Inhaled Controller Medication Among Older Adults with Asthma: A Cross-Sectional Study in Primary Care</p>

Chang-wei¹,

Tham²,

Roza³

et al. 2020

PPA

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Background: While illness perceptions and medication beliefs have been shown to be associated with inhaled corticosteroid (ICS) adherence in younger adults with asthma, their impact on older adults is less understood. This study aimed to determine the prevalence of ICS adherence among older Asian adults and to assess the association between ICS adherence, illness perceptions and medication beliefs. Methods: A questionnaire survey on older multi-ethnic Asian patients, aged ≥60 years, with physician-diagnosed asthma, was conducted in two Singapore public primary care clinics. The scores of the Medication Adherence Report Scale for asthma (MARS) were computed to determine the adherence to ICS alone or in combination with LABA. Illness perceptions and medication beliefs were assessed by the scores from the Brief-Illness Perception Questionnaire (B-IPQ) and Beliefs about Medications Questionnaire (BMQ), respectively. Logistic regression analyses were used to identify factors associated with ICS adherence. Results: Analyses of 323 participants (57% males; Chinese 73.7%, Malay 12.7%, Indian 12.4%; mean age 71.5 years) showed that 40.9% of them had good adherence to ICS (mean MARS score≥4.5). Good adherence to ICS was associated with perception of asthma as a chronic illness (OR=1.22; 95% CI=1.10-1.35; p<0.001), belief of ICS as an essential medication (2.67; 1.76-4.06; p<0.001) and fewer concerns about its use (0.39; 0.26-0.60; p<0.001). Patients on combined ICS-LABA therapy had higher adherence (2.50; 1.41-4.44; p=0.02) than those on ICS monotherapy. Conclusion: Four in ten older patients with asthma were adherent to ICS. Perception of medication necessity, chronicity of illness, concerns and use of ICS-LABA medication were associated with adherence.

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“…Logistic regression analyses showed good ICS adherence was associated with perception of asthma as an illness with a longer timeline (OR=1.22; 95% CI=1.10-1. 35…”

Section: Results Of Logistic Regressionmentioning

confidence: 99%

Section: Strengths and Limitationsmentioning

confidence: 95%

See 1 more Smart Citation

<p>The Association Between Beliefs and Adherence to Inhaled Controller Medication Among Older Adults with Asthma: A Cross-Sectional Study in Primary Care</p>

Chang-wei¹,

Tham²,

Roza³

et al. 2020

PPA

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“…The parasympathetic neurotransmitter, acetylcholine (ACh), is a key pathophysiologic factory involved in precipitating multiple changes in asthmatic air passages; it stimulates airway smooth muscle spasm, mucus hpersecretion in addition to airway remodeling through its effects on many types of muscarinic (M) receptors which are M1, M2 and M3 receptors (5) . The most important goal of persistent asthma treatment is to achieve the maximum possible extent of asthma control by decreasing the frequency and severity of asthma symptoms (6) , enhance patients' QoL (7) status and improve the pulmonary function test (PFT) parameters which represent objective measure of airway obstruction (8) . Inhaled corticosteroids (ICS.s) are the most effective and are considered the first line anti-inflammatory drug for controlling moderate or severe persistent asthma when co-administered with one or more controller medication; the dose requirement of ICS increases as severity worsens (9) .…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Clinical Outcomes of Three Medication Regimens for Treating a Sample of Iraqi Persistent Asthmatic patients

Jasim

Saleh²,

Ali³

2020

IJPS

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Abstract Asthma is a complex disease defined by chronic airway inflammation and airflow limitation causing variable respiratory symptoms which include shortness of breath (SOB), wheezing, chest tightness and cough. Asthma guidelines advocate adding a second long acting bronchodilator to medium doses of inhaled corticosteroids (ICS) rather using high doses of ICS alone to control moderate to severe persistent asthma. The aim of this study was to evaluate the clinical outcomes of three medication regimens indicated for Iraqi patients suffering from persistent asthma. This study was interventional randomized clinical study conducted on a sample of adult Iraqi asthmatic patients in Baghdad City. The study composed of three visits distributed over eight weeks; baseline visit followed by first follow up and second follow up visits after four and eight weeks respectively. The study enrolled 78 adult patients with moderate to severe persistent asthma as diagnosed by specialist physician according to patient history and baseline pulmonary function test (PFT) and allocated them randomly to three groups (each group included 26 patients) to receive equivalent medium doses of budesonide inhaler in addition to either formoterol inhaler, oral modified release aminophylline tablets or tiotropium inhaler (first, second and third group respectively). Sixty four patients completed this study. The mean ages of patients were above 35 years with slightly more male predominance. The study groups developed significant increase of peak expiratory flow rate (PEFR) and forced vital capacity (FVC) values at the first follow up visit compared to baseline values (p<0.001). Thereafter, the first and third groups achieved significant higher values at the second follow up visit compared to first follow up visit (p<0.001), while second group produced no change. All the groups developed significant improvement of Mini asthma quality of life questionnaire (MiniAQLQ) scores and percentage of symptom free days (SFD) at first follow up visit and continued further significant improvement at the second follow up visit (p<0.001). Generally, between groups comparison according to extent of change of study parameters revealed that third group produced the greatest improvement over the entire study period followed by the first group, whereas the second group was associated with the least extent of improvement. This study concluded that all groups caused significant improvement in study parameters compared to baseline values and also concluded that the third group of inhaled [tiotropium/budesonide] was associated with the highest extent of improvement followed by first group, while the second group was the least.

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“…Spirometry is the lung function test of great importance to diagnose asthma and to monitor the effects of treatment. FEV1 (forced expiratory volume in first second) and FVC (forced vital capacity) are the most important measurements can be done from spirometry along with, monitoring the PEFR that is useful in detecting changes in a patient's asthma control on disease severity [15][16] . YKL-40 is an N-terminal amino acids, and 40 shows its molecular mass, which is in kilodaltons (KDa) 17 .…”

mentioning

confidence: 99%

Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital

Fatima¹,

Khan²,

Iqbal³

2018

J. Bahria Uni. Med. Dent. Coll.

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Objective: To correlate serum levels of YKL-40 with anthropometric measurements and spirometric indices between normal individuals and asthmatics. Methodology: The case control study was conducted in Department of Chest Medicine, JPMC, Karachi from the month of August 2015 till March 2016. The study recruited sixty participants after satisfying the inclusion and exclusion criteria; among those 30 were normal healthy individuals (PEF > 80% and pulse rate of 60 – 80 beats per minutes); while equal were cases of mild to moderate asthma (PEF more than 50% and pulse rate of 100 – 120 beats per minutes) matched for age and gender. Vitallograph compacta and peak flow meter was used for spirometric indices. Moreover, anthropometric measurements were age, gender, weight (kg), height (m) and body mass index (kg/m2). Ykl-40 Elisa kit was used for serum YKL 40 levels. The data was entered and analysed using SPSS version 21 (IBM, Chicago, IL). Result: In comparison of Spirometric Evaluation (FEV1, FVC, FEV1/FVC% and PEFR) between control and patients with mild to moderate asthma. significant difference was found in the mean values of FEV1, FVC, FEV1/FVC and PEFR between cases and controls. Significant inverse correlation was found between YKL-40 with FEV1, FVC, FEVI/FVC% and PEFR among Controls. YKL-40 was found to be significantly correlated with only FEV1/ FVC (%) among cases with correlation co-efficient as – 0.510 (p-value < 0.004). Conclusion: There is an inverse correlation between serum YKL-40 levels and spirometric evaluation thus as the inflammation in asthma increases, YKL-40 level upsurges and causes decrease in lung function tests.

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Accuracy of spirometry for detection of asthma: a cross-sectional study

Cited by 7 publications

References 17 publications

<p>The Association Between Beliefs and Adherence to Inhaled Controller Medication Among Older Adults with Asthma: A Cross-Sectional Study in Primary Care</p>

<p>The Association Between Beliefs and Adherence to Inhaled Controller Medication Among Older Adults with Asthma: A Cross-Sectional Study in Primary Care</p>

Evaluating the Clinical Outcomes of Three Medication Regimens for Treating a Sample of Iraqi Persistent Asthmatic patients

Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital

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