Association between asthma and female sex hormones

Baldaçara, Raquel Prudente de Carvalho; Silva, Ivaldo

doi:10.1590/1516-3180.2016.011827016

Cited by 36 publications

(44 citation statements)

References 73 publications

(161 reference statements)

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“…The result is in line with previously published works [30][31][32]. A number of unpublished and published articles mentioned the protective value of testosterone over a fl uctuating concentration of estrogen in females in reducing the risk of onset of asthma and its symptoms [33]. Among asthmatic patients, the larger proportions were housewives.…”

Section: Discussionsupporting

confidence: 90%

Prevalence of Asthma and Its Association with Daily Habits in Jimma Town, Ethiopia

Ayana¹

2018

Open J Asthma

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Background: Many studies showed a low risk of asthma in sub-Saharan countries. However, due to indoor pollutions and environmental hazards, developing countries are always the prior victims of all types of respiratory illnesses including asthma. Jimma, southwestern Ethiopia, is known by its wide range of vegetations including khat and coffee. Together with high plantation of those cash crops, there is widespread consumption of them by the locals. Objective: To investigate prevalence and severity of bronchial asthma and its association with daily habits in Jimma town, Ethiopia Methods and Materials: A community-based cross-sectional study was conducted in Jimma town on 1300 participants. Systematic random sampling technique was employed to select households. Semistructured questionnaire and pulmonary function tests were used to collect data. SPSS was used to execute simple descriptive, independent t-tests and chi-square. Results: Chewer participants had higher pulmonary function tests. Khat might indeed have bronchodilating effect when chewed before the measurement. Except for FVC; the other pulmonary function test parameters were higher among coffee consumers. The bronchodilating effect of caffeine may increase pulmonary function parameters. In the current study, the prevalence of asthma in Jimma town was 4.9%. A signifi cantly large proportion of asthmatic smokers had asthmatic symptoms in once or more than once per week [χ2-20.208, p-0.00]. Conclusion and clinical Relevance: Bronchial asthma is public health burdon in Jimma town. FVC, FEV and PEFR functional parameters were lower in asthmatic patients when compared to nonasthmatic participants that may indicates the severity of asthma in the study area. Lung functions, onset, severity & asthma managements could be affected by the daily consumption of khat, coffee, and cigarette.

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Section: Discussionsupporting

confidence: 90%

Prevalence of Asthma and Its Association with Daily Habits in Jimma Town, Ethiopia

Ayana¹

2018

Open J Asthma

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“…PMA is less likely to be associated with atopy, but more frequently with aspirin sensitivity and poorer pulmonary function [ 29 ]. Currently the main cause for PMA is considered to be the dynamics or fluctuation rather than the absolute hormone levels, particularly of oestrogen [ 18 , 30 ].…”

Section: Symptoms In Relation To Female Sex Hormonesmentioning

confidence: 99%

Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update

Koper¹,

Hufnagl

Ehmann³

2017

World Allergy Organization Journal

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There is good evidence for gender-specific differences in asthma regarding all affected areas, from intra-to extracellular mediators to the whole organ structure und functioning of the lung. These result from complex, in parts synergistic, in other parts opposing, effects -especially of female sex hormones, and rather protective effects of male hormones against asthma, which include effects on the cellular immune system. Additionally, there are gender differences of sociocultural origin, regarding presentation, doctor's diagnosis and treatment of asthma symptoms, as well as the undertaken coping strategies concerning the female or male patient's complaints. Taking into account gender-specific differences in asthma would contribute to improved individual diagnosis and therapies.

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“…Differences in asthma incidence during menopause period lend further support to the idea that sex-related differences may be influenced by alterations in levels of the female sex hormones. Indeed, the overall incidence of asthma in women decreases after menopause (Fuseini and Newcomb, 2017;Baldaçara and Silva, 2017). This was supported by studies showing that the use of postmenopausal hormone therapy was associated with an increased rate of newly diagnosed asthma in menopausal women (Bonnelykke et al, 2015;Dratva, 2010).…”

Section: Discussionmentioning

confidence: 95%

Association of High-Affinity FcεRI-β intron 2 for IgE Gene Polymorphism and Atopic Diseases in an Algerian Population

Dahmani¹,

Salem²,

Chakir³

et al. 2017

OnLine Journal of Biological Sciences

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Atopy is characterized by the production of a high level of IgE in response to common allergens. We examined the RsaI-in2 polymorphism of the FcεRI-β gene and its association with atopic asthma and comorbidity. The study population included 77 atopic asthmatics and 77 non-atopic, nonallergic and non-asthmatic controls. Atopic asthma was confirmed by the skin prick test and by IgE and interleukin IL-4 levels. RsaI-in2 polymorphism was determined by RFLP-PCR using the RsaI enzyme. A significant correlation was found between genotype BB and sensitization to house dust mites in the asthmatic subjects (p = 0.000). Results also reveal significant allele sharing in the subjects affected by eczema (p = 0.000) and allergic rhinitis (p = 0.01) during childhood. Furthermore, the subjects with heterozygous AB and homozygous BB genotypes displayed significant IgE levels > 1000 UI mL −1 . IL-4 levels were also > 1000 pmol/ml for RsaI-in2 polymorphism genotype BB. Our findings show a strong association between genotype BB and the incidence of eczema and allergic rhinitis in childhood as well as increased IgE and IL-4 levels.

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Association between asthma and female sex hormones

Cited by 36 publications

References 73 publications

Prevalence of Asthma and Its Association with Daily Habits in Jimma Town, Ethiopia

Prevalence of Asthma and Its Association with Daily Habits in Jimma Town, Ethiopia

Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update

Association of High-Affinity FcεRI-β intron 2 for IgE Gene Polymorphism and Atopic Diseases in an Algerian Population

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