Smoking and cancer: Brazil and the Global Burden of Disease initiative

Lotufo, Paulo A.

doi:10.1590/1516-3180.2015.13353108

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…In addition, little is known about these associations in Latin American and Caribbean populations such as that of Brazil. 25 The present study aimed to examine the associations between cigarette smoking and inflammation and subclinical atherosclerosis in ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). We hypothesized that cigarette smoking, as assessed by status (current or former), burden (pack-years), time since quitting, and intensity of smoking (cigarettes per day), is associated with inflammation and subclinical atherosclerosis.…”

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confidence: 99%

Associations of Cigarette Smoking With Subclinical Inflammation and Atherosclerosis: ELSA‐Brasil (The Brazilian Longitudinal Study of Adult Health)

Kianoush¹,

Yakoob²,

Al‐Rifai

et al. 2017

JAHA

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BackgroundThere is a need to identify sensitive biomarkers of early tobacco‐related cardiovascular disease. We examined the association of smoking status, burden, time since quitting, and intensity, with markers of inflammation and subclinical atherosclerosis.Methods and ResultsWe studied 14 103 participants without clinical cardiovascular disease in ELSA‐Brasil (Brazilian Longitudinal Study of Adult Health). We evaluated baseline cross‐sectional associations between smoking parameters and inflammation (high‐sensitivity C‐reactive protein [hsCRP]) and measures of subclinical atherosclerosis (carotid intima–media thickness, ankle‐brachial index, and coronary artery calcium [CAC]). The cohort included 1844 current smokers, 4121 former smokers, and 8138 never smokers. Mean age was 51.7±8.9 years; 44.8% were male. After multivariable adjustment, compared with never smokers, current smokers had significantly higher levels of hsCRP (β=0.24, 0.19–0.29 mg/L; P<0.001) and carotid intima–media thickness (β=0.03, 0.02–0.04 mm; P<0.001) and odds of ankle‐brachial index ≤1.0 (odds ratio: 2.52; 95% confidence interval, 2.06–3.08; P<0.001) and CAC >0 (odds ratio: 1.83; 95% confidence interval, 1.46–2.30; P<0.001). Among former and current smokers, pack‐years of smoking (burden) were significantly associated with hsCRP (P<0.001 and P=0.006, respectively) and CAC (P<0.001 and P=0.002, respectively). Among former smokers, hsCRP and carotid intima–media thickness levels and odds of ankle‐brachial index ≤1.0 and CAC >0 were lower with increasing time since quitting (P<0.01). Among current smokers, number of cigarettes per day (intensity) was positively associated with hsCRP (P<0.001) and CAC >0 (P=0.03) after adjusting for duration of smoking.ConclusionsStrong associations were observed between smoking status, burden, and intensity with inflammation (hsCRP) and subclinical atherosclerosis (carotid intima–media thickness, ankle‐brachial index, CAC). These markers of early cardiovascular disease injury may be used for the further study and regulation of traditional and novel tobacco products.

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confidence: 99%

Associations of Cigarette Smoking With Subclinical Inflammation and Atherosclerosis: ELSA‐Brasil (The Brazilian Longitudinal Study of Adult Health)

Kianoush¹,

Yakoob²,

Al‐Rifai

et al. 2017

JAHA

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“…Cancer is a worldwide disease [ 1 – 3 ]. A report from the National Cancer Institute (NCI), titled “Statistics at a Glance: The Burden of Cancer Worldwide,” said, “cancer was among the global leading fatality with 14.1 million cases which emerged in 2012 alongside with cancer-related issues of 8.2 million globally” [ 4 ].…”

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confidence: 99%

Metal Nanoparticles: Thermal Decomposition, Biomedicinal Applications to Cancer Treatment, and Future Perspectives

Odularu

2018

Bioinorganic Chemistry and Applications

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Monodispersed forms of metal nanoparticles are significant to overcome frightening threat of cancer. This review examined pragmatically thermal decomposition as one of the best ways to synthesize monodispersed metal nanoparticles which are stable and of small particle sizes. Controlled morphology for delivery of anticancer agent to specific cells can also be obtained with thermal decomposition. In addition to thermal decomposition, the study also looked into processes of characterization techniques, biological evaluation, toxicity of nanoparticles, and future perspectives.

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“…1 Several studies have demonstrated a strong relationship between smoking and various types of diseases in the adult population, such as carotid calcification 2 and other cardiovascular problems, like stroke. 3 However, this type of behavior has been detected not only among adults, but also in young populations.…”

Section: Introductionmentioning

confidence: 99%

Smoking among adolescents is associated with their own characteristics and with parental smoking: cross-sectional study

et al. 2017

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BACKGROUND:This study aimed to analyze the association between smoking during adolescence and the characteristics of smoking and alcohol consumption among their parents. DESIGN AND SETTING: Cross-sectional study in Londrina (PR), Brazil. METHODS:The subjects comprised 1,231 adolescents aged 14-17 years. The adolescents and their parents answered a self-report questionnaire that asked for sociodemographic information and data on smoking and alcohol consumption. Multiple logistic regression models were used to analyze associations between smoking among adolescents and their characteristics (age, sex, period of the day for attending school, alcohol consumption and socioeconomic level) and their parents' characteristics (smoking, alcohol consumption, age and education level), adjusted according to the adolescents' characteristics (sex, age and socioeconomic level). RESULTS:The prevalence of smoking among adolescents was 3.4% (95% confidence interval, CI: 2.4-4.4). Adolescents whose mothers or fathers were smokers were 2.0 and 2.5 times more likely to be smokers, respectively. The prevalence of smoking among adolescents with a smoking mother was 7.1% (95% CI: 2.6-10.7) and a smoking father, 5.4% (95% CI: 1.6-8.5). There were significant associations between smoking adolescents and age [5.2% (95% CI: 3.3-6.6)], studying at night [9.6% (95% CI: 4.0-15.5)] and alcohol consumption [69.0% (95% CI: 55.0-83.0)]. It was observed that the number of alcoholic beverage doses consumed was higher among smoking adolescents (P = 0.001). CONCLUSION: Adolescent smoking was associated with smoking by their parents, regardless of the gender of the parents or adolescents. Age, alcohol consumption and studying at night are characteristics of adolescents that can contribute towards smoking. IMSc. Physiotherapist,

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Smoking and cancer: Brazil and the Global Burden of Disease initiative

Cited by 3 publications

References 5 publications

Associations of Cigarette Smoking With Subclinical Inflammation and Atherosclerosis: ELSA‐Brasil (The Brazilian Longitudinal Study of Adult Health)

Associations of Cigarette Smoking With Subclinical Inflammation and Atherosclerosis: ELSA‐Brasil (The Brazilian Longitudinal Study of Adult Health)

Metal Nanoparticles: Thermal Decomposition, Biomedicinal Applications to Cancer Treatment, and Future Perspectives

Smoking among adolescents is associated with their own characteristics and with parental smoking: cross-sectional study

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