Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China

Wang, Zhong; Chen, Shaoze; Zhang, Lina; Lu, Guilin; Zhou, Can; Wang, Dao Wen; Wang, Li; Badengmu, Bayinbate; Zhai, Zhensheng; Qin, Lian

doi:10.1590/1516-3180.2015.01150108

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…Similarly, a "second look" into the proteases that allow for intracellular non-canonical complement activation may also be informative. For example, a novel functional polymorphism in the CTSL gene alters blood pressure (Mbewe-Campbell et al, 2012), and changes in the CTSL gene promotor have been connected with hypertension (Chen et al, 2015)potential changes, however, in C3 processing within the endothelium are unexplored. Interestingly, complement seems not to play a role in normal renal function.…”

Section: Non-canonical Complement and Sensor System Crosstalks-evolutionary Cluesmentioning

confidence: 99%

The role of complement in arterial hypertension and hypertensive end organ damage

Wenzel

Kemper

Bode

2020

British J Pharmacology

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Increasing evidence indicates that hypertension and hypertensive end organ damage are not only mediated by haemodynamic injury but that inflammation also plays an important role. The complement system protects the host from a hostile microbial environment and maintains tissue and cell integrity through the elimination of altered or dead cells. As an important effector arm of innate immunity, it plays also central roles in the regulation of adaptive immunity. Thus, complement activation may drive the pathology of hypertension through its effects on innate and adaptive immune responses, aside from direct effects on the vasculature. Recent experimental data strongly support a role for complement in all stages of arterial hypertension. The remarkably similar clinical and histopathological features of malignant nephrosclerosis and atypical haemolytic uraemic syndrome suggest also a role for complement in the development of malignant nephrosclerosis. Here, we review the role of complement in hypertension and hypertensive end organ damage. Linked Articles This article is part of a themed issue on Canonical and non‐canonical functions of the complement system in health and disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc

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Section: Non-canonical Complement and Sensor System Crosstalks-evolutionary Cluesmentioning

confidence: 99%

The role of complement in arterial hypertension and hypertensive end organ damage

Wenzel

Kemper

Bode

2020

British J Pharmacology

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“…However, hypertension was less prevalent compared to other international studies. Whether this is related to sample volume and methodology or ethnicity, which is known to plays a major role in the prevalence of hypertension, its response to treatment and related mortality; needs to be clarified by further study (19)(20)(21)(22) . Diabetes has the highest incidence in our patients compared to other studies.…”

Section: Initial Diagnosismentioning

confidence: 99%

Clinical Characteristics and Outcomes of Acute Coronary Syndromes in a Group of Iraqi Patients

2016

IJMS

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Background Coronary artery disease (CAD) is one of the most common diseases in the world. Acute coronary syndromes (ACS) represent the acute life-threatening phase of CAD. Epidemiology and management of ACS patients differ a lot between countries and there is a wide gap between guidelines and clinical practice. Objective To assess contemporary data on clinical characteristics and outcomes of patients with ACS in the Medical City Complex and to evaluate adherence to the guidelines' recommended treatment. Methods This is a descriptive study registry, started on January 2014 to June 2014, and involved 348 patients with ACS in the Medical City Complex. Results The mean age of this study's population was (60.3±11.2 years), ranging between 29 to 90 years old. Most of patients were males (61%). Only 233 (67%) patients have typical angina. Symptom onsetto-admission time was delayed (≥ 12 hours) in 65% of patients. The final diagnosis was: ST elevation myocardial infarction (STEMI) in 126 (36.2%), non ST elevation myocardial infarction (NSTEMI) in 40 (11.4%), and unstable angina (UA) in 182 (52.3%) of patients. Electrocardiography was normal in 29% of patients with UA and 10% of patients with NSTEMI. Anterior territory was the most common location of ischemia (77%). Hypertension (47.9%) was the most significant risk factor followed by diabetes mellitus (41.6%) and smoking (31.8%). Reperfusion therapy for patients with STEMI was applied in 73(57%) patients: 56 (44.4%) by thrombolytic therapy, 24 (19%) by percutaneous coronary intervention (PCI) and 3 (2.3%) by emergency CABG. Overall in-hospital mortality was 7.7% (15%, 7.5% and 2.7% for STEMI, NSTEMI, and UA respectively). Conclusion There is lack of awareness of ischemic symptoms among our patients. There is high incidence of risk factors that can be modified by primary and secondary measures. There is underutilization of invasive management. We have a high mortality rates in patients with ACS.

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“…DDAH2 encodes a dimethylarginine dimethylaminohydrolase, which is important in nitric oxide generation by regulating the cellular concentrations of methylarginines. DDAH2 has been demonstrated to be associated with various types of disease, including hypertension ( 28 ), type 2 diabetes ( 29 ) and cancer. Upregulation of DDAH2 is associated with the invasiveness of lung adenocarcinoma by inducing proliferation and capillary-like tube formation of vascular endothelial cells ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Whole‑transcriptome sequencing profiling identifies functional and prognostic signatures in patients with PTPRZ1‑MET fusion‑negative secondary glioblastoma multiforme

Chen

Wang

et al. 2020

Oncol Lett

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Gliomas are the most common type of primary brain tumor in adults with a high mortality rate. Low-grade gliomas progress to glioblastoma multiforme (GBM) in the majority of cases, forming secondary GBM (sGBM), followed by rapid fatal clinical outcomes. Protein tyrosine phosphatase receptor type Z1 (PTPRZ1)-MET proto-oncogene receptor tyrosine kinase (MET) (ZM) fusion has been identified as a biomarker for sGBM that is involved in glioma progression, but the mechanism of gliomagenesis and pathology of ZM-negative sGBM has remained to be fully elucidated. A whole-transcriptome signature is thus required to improve the outcome prediction for patients with sGBM without ZM fusion. In the present study, whole-transcriptome sequencing on 42 sGBM samples with or without ZM fusion from the Chinese Glioma Genome Atlas database identified mRNAs with differential expression between patients with and without ZM fusion and the most significant survival-associated genes were identified. A 6-gene signature was identified as a novel prognostic model reflecting survival probability in patients with ZM-negative sGBM. Clinical characteristics in patients with a high or low risk score value were analyzed with the Kaplan-Meier method and a two-sided log-rank test. In addition, ZM-negative sGBM patients with a high risk score exhibited an increase in immune cells, NF-κB-induced pathway activation and a decrease in endothelial cells compared with those with a low risk score. The present study demonstrated the potential use of a next-generation sequencing-based cancer gene signature in patients with ZM-negative sGBM, indicating possible clinical therapeutic strategies for further treatment of such patients.

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Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China

Abstract: Our results indicated that the C-allele of rs3087894 in DDAH1 was a risk factor for hypertension in the Kazakh group but a protective factor in the Uygur group.

Cited by 6 publications

References 26 publications

The role of complement in arterial hypertension and hypertensive end organ damage

The role of complement in arterial hypertension and hypertensive end organ damage

Clinical Characteristics and Outcomes of Acute Coronary Syndromes in a Group of Iraqi Patients

Whole‑transcriptome sequencing profiling identifies functional and prognostic signatures in patients with PTPRZ1‑MET fusion‑negative secondary glioblastoma multiforme

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