Usefulness of the second heart sound for predicting pulmonary hypertension in patients with interstitial lung disease

Cobra, Sandra de Barros; Cardoso, Rayane Marques; Rodrigues, Marcelo Palmeira

doi:10.1590/1516-3180.2015.00701207

Cited by 2 publications

(3 citation statements)

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“…PH remains poorly investigated among patients in the early stages of IPF because cardiac catheterization -the gold standard for definitive diagnosis of changes in pulmonary circulation and its repercussions in the right chamber [6] -is not usually performed for clinical follow-up. Furthermore, the clinical signs and symptoms are insufficient for a diagnosis of PH in such patients [7,8].…”

Section: Introductionmentioning

confidence: 99%

Right ventricular dysfunction in patients with non-severe idiopathic pulmonary fibrosis: a cross-sectional prospective single-center study

Cobra

Rodrigues

Melo

et al. 2020

Expert Review of Respiratory Medicine

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Background: Little is known about right ventricular dysfunction in non-advanced idiopathic pulmonary fibrosis (IPF) patients without hypoxemia at rest. We evaluated it at rest and during exercise. Research design and methods: 123 IPF patients were evaluated, and 27 met all the following criteria: Gender-Age-Physiology Index score ≤5, modified Medical Research Council dyspnea score ≤3, peripheral oxygen saturation ≥92% at rest, and no history of oxygen therapy. They were submitted to twodimensional speckle-tracking echocardiography at rest and during cardiopulmonary exercise to analyze right ventricular global longitudinal strain. Results: Abnormal speckle-tracking echocardiography findings were identified in 10/27 patients (37%), indicating right ventricular (RV) dysfunction. No patients had abnormalities observed in conventional echocardiographic parameters. Significant differences in mPAP were observed between patients with RV dysfunction and those without dysfunction (at rest: 26.0 ± 4.8 vs. 19.1 ± 4.2 mmHg, p = 0.001; during exercise: 51.3 ± 6.4 vs. 36.9 ± 14.7 mmHg, p = 0.002). Conclusions: RV dysfunction was detected in 37% of non-advanced IPF patients and early recognition was only possible using speckle-tracking echocardiography. Special attention should be given to these patients as RV dysfunction is suggestive of worse prognosis. These patients could benefit from new specific drugs or even oxygen therapy for transitory hypoxia.

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Section: Introductionmentioning

confidence: 99%

Right ventricular dysfunction in patients with non-severe idiopathic pulmonary fibrosis: a cross-sectional prospective single-center study

Cobra

Rodrigues

Melo

et al. 2020

Expert Review of Respiratory Medicine

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Estudo da utilização das mídias sociais no desenvolvimento de coleções de moda

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Usefulness of the second heart sound for predicting pulmonary hypertension in patients with interstitial lung disease

Abstract: The semiological signs indicative of PH presented low sensitivity and specificity levels for clinically diagnosing this comorbidity.

Cited by 2 publications

References 26 publications

Right ventricular dysfunction in patients with non-severe idiopathic pulmonary fibrosis: a cross-sectional prospective single-center study

Right ventricular dysfunction in patients with non-severe idiopathic pulmonary fibrosis: a cross-sectional prospective single-center study

Estudo da utilização das mídias sociais no desenvolvimento de coleções de moda

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