Diagnostic accuracy of a noninvasive hepatic ultrasound score for non-alcoholic fatty liver disease (NAFLD) in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Abstract

CONTEXT AND OBJECTIVE: Noninvasive strategies for evaluating non-alcoholic fatty liver disease (NAFLD) have been investigated over the last few decades. Our aim was to evaluate the diagnostic accuracy of a new hepatic ultrasound score for NAFLD in the ELSA-Brasil study. DESIGN AND SETTINGS: Diagnostic accuracy study conducted in the ELSA center, in the hospital of a public university. METHODS: Among the 15,105 participants of the ELSA study who were evaluated for NAFLD, 195 individuals were included in this sub-study. Hepatic ultrasound was performed (deep beam attenuation, hepatorenal index and anteroposterior diameter of the right hepatic lobe) and compared with the hepatic steatosis findings from 64-channel high-resolution computed tomography (CT). We also evaluated two clinical indices relating to NAFLD: the fatty liver index (FLI) and the hepatic steatosis index (HSI). RESULTS: Among the 195 participants, the NAFLD frequency was 34.4%. High body mass index, high waist circumference, diabetes and hypertriglyceridemia were associated with high hepatic attenuation and large anteroposterior diameter of the right hepatic lobe, but not with the hepatorenal index. The hepatic ultrasound score, based on hepatic attenuation and the anteroposterior diameter of the right hepatic lobe, presented the best performance for NAFLD screening at the cutoff point

Chronic kidney disease - determinants of progression and cardiovascular risk. PROGREDIR cohort study: design and methods

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Frequency of cholecystectomy and associated sociodemographic and clinical risk factors in the ELSA-Brasil study

“…More details about the liver ultrasound examination have been published elsewhere. 16 Participants who did not report having had any previous cholecystectomy or did not undergo hepatic ultrasound were excluded from the analysis.…”

Prevalence of Fatty Liver and Its Association With High Total Cholesterol in People of Tumkur, India

“…Among these criteria, deepbeam attenuation has presented better performance for diagnosing fatty liver disease. [6,7] A high Total Cholesterol (TC) level is associated with the risk of coronary heart disease [8,9] and abnormal glucose metabolism. [6] We investigated the prevalence of NAFLD in association with total cholesterol levels whether it is significantly associated with those with high total cholesterol levels.…”