Pattern, clinical features and response to corticoids                     of glomerular diseases in a Brazilian population. An analytical cross-sectional                     study

Queiroz, Anaiara Lucena; Barreto, Dulce Maria Sousa; Silva, Geraldo Bezerra da; Neto, José Edísio da Silva Tavares; Costa, Francisco Israel; Patrocínio, Régia Maria do Socorro Vidal; Daher, Elizabeth De Francesco; Almeida, Paulo Roberto Carvalho de

doi:10.1590/1516-3180.2013.7360006

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…For primary glomerulonephritis, FSGS was the prevalent histology, followed by IgAN, MN, MCD and MPGN, with frequencies similar to those described in Brazilian registries [ 12 – 14 , 24 ] and in North and South American countries [ 4 , 5 , 16 , 25 ]. In the study by Polito et al [ 12 ], the prevalence of FSGS, MN, IgAN, MCD and MPGN was 24.6, 20.7, 20.1, 15.5 and 4.2%, respectively, which was similar to that described by Malafronte et al [ 13 ], who reported frequencies of 29.7, 20.7, 17.8, 9.1 and 7% for the same pathologies.…”

Section: Discussionsupporting

confidence: 64%

The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

et al. 2021

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Background The prevalence and distribution of glomerular diseases differ among countries, and the indication to perform a kidney biopsy varies among centres. In this study, we assessed the prevalence of primary and secondary glomerulopathies based on histological diagnoses, and the correlation between glomerulopathies and demographic and clinical data was evaluated. Methods In this study, 1051 kidney biopsies were retrospectively reviewed between 2000 and 2018. Patient demographic, clinical and laboratory data were assessed. The prevalence of primary glomerulonephritis (PG) and secondary glomerulopathies (SG), as well as tubulointerstitial diseases (TIDs), hereditary nephropathies (HNs) and other diagnoses, were determined. The frequency of primary and secondary glomerulopathies was evaluated by age group, and the temporal variation in frequencies across three time periods (2000-2005, 2006-2011, and 2012-2018) was reported. Results The prevalence of SG predominated (52.4%), followed by PG (29.6%), other diagnoses (10.7%), TID (6.6%) and HN (1.1%). Among the primary forms of glomerular disease, focal segmental glomerulosclerosis (FSGS) was the most common (37.3%), followed by IgA nephropathy (IgAN, 24.4%), membranous nephropathy (MN, 18.6%) and minimal change disease (MCD, 8.4%). Lupus nephritis (LN, 41.1%) was most common in patients with SG, followed by diabetic kidney disease (DKD, 17.8%), systemic vasculitis (SV, 10.2%) and secondary FSGS (2nd FSGS, 10%). Nephrotic syndrome was the most common clinical presentation in patients with PG and also in patients with DRD and 2nd FSGS, whereas in patients with IgAN and SV, nephritic syndrome was the main presentation. For the age group between 18 and 50 years, LN, FSGS and IgAN predominated; for patients aged between 51 and 65 years, the proportion of DKD and 2nd FSGS increased, and SV was more common in patients > 65 years. The temporal variation in PG across the three time periods showed a statistically significant increase in IgAN (p = 0.001) and a reduction in FSGS over time (p < 0.001). In SG, there was a reduction in LN (p = 0.027) and an increase in DKD (p < 0.001) over time, with a tendency for 2nd FSGS to decrease over time (p = 0.053). Conclusions In the studied kidney biopsy registry, FSGS and IgAN were the most prevalent diagnoses in patients with PG, and LN and DKD were the most prevalent in patients with SG. Nephrotic syndrome was the major indication for biopsy. When comparing the temporal variation in glomerulopathies, there was a reduction in FSGS and an increase in IgAN in patients with PGs over time, and for patients with SGs, there was a reduction in LN with an increase in cases of DKD over time.

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Section: Discussionsupporting

confidence: 64%

The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

et al. 2021

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“…In primary glomerulonephritis, FSGS was the prevalent histology, followed by IgAN, MN, MCD and MPGN, with frequencies similar to those described in Brazilian registries [12][13][14]24 and in North and South American countries 4,5,16,25 . In the study by Polito et al 12 , the prevalence of FSGS, MN, IgAN, MCD and MPGN were 24.6%, 20.7%, 20.1%, 15.5% and 4.2%, respectively, which was similar to that described by Malafronte et al 13 who reported frequencies of 29.7%, 20.7%, 17.8%, 9.1% and 7% for the same pathologies.…”

Section: Discussionsupporting

confidence: 60%

The Spectrum of Biopsy-Proven Glomerular Diseases in a Tertiary Hospital in Southern Brazil

Thomé

Bianchini

Bringhenti

et al. 2021

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Background The prevalence and distribution of glomerular diseases differs between countries, and the indication to perform a kidney biopsy varies in each center. In this study, we assessed the prevalence of primary and secondary glomerulopathies based on histological diagnosis, and their correlation with demographic and clinical data were evaluated. Methods It was included in the study 1051 kidney biopsies retrospectively reviewed between the years 2000 to 2018. Demographic, clinical and laboratory data of patients were assessed. The prevalence of primary glomerulonephritis (PG) and secondary glomerulopathies (SG), as well as tubulo-interstitial diseases (TID), hereditary nephropathies (HN) and other diagnosis, were described. The frequency of primary and secondary glomerulopathies was evaluated by age group, and their temporal variation in three time periods (2000–2005, 2006–2011, and 2012–2018) were reported. Results The prevalence of SG predominated (52.4%) followed by PG (29.6%), other diagnoses (10.7%), TID (6.6%) and HN (1.1%). In primary forms, focal segmental glomerulosclerosis (FSGS) prevailed (37.3%), followed by IgA nephropathy (IgAN, 24.4%), membranous nephropathy (MN, 18.6%) and minimal change disease (MCD, 8.4%). Lupus nephritis (LN, 41.1%) had the highest frequency in SG, and in sequence diabetic kidney disease (DKD, 17.8%), systemic vasculitis (SV, 10.2%) and secondary FSGS (2nd FSGS, 10%). Nephrotic syndrome was the most common clinical presentation in PG, and also in DRD and 2nd FSGS, whereas in IgAN and SV the nephritic syndrome was the main form of presentation. In the age group between 18–50 years, LN, FSGS and IgAN predominated, between 51–65 years the proportion of DKD and 2nd FSGS increased, and SV were more found in patients > 65 years. The temporal variation of PG in three time periods showed a statistically significant increase in IgAN (p = 0.001) and a reduction in FSGS (p < 0.001). In SG, there were a reduction in LN (p = 0.027) and increase in DKD (p < 0.001), with a tendency to decrease of 2nd FSGS (p = 0.053). Conclusions In this kidney biopsy registry, FSGS and IgAN were the prevalent diagnoses in PG, and LN and DKD in SG. Nephrotic syndrome was the major indication for biopsy. When comparing the temporal variation of glomerulopathies, there was a reduction in FSGS and an increase in IgAN in PGs, and in SGs a reduction of LN with an increase in cases of DKD.

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Pattern, clinical features and response to corticoids of glomerular diseases in a Brazilian population. An analytical cross-sectional study

Cited by 2 publications

References 25 publications

The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

The Spectrum of Biopsy-Proven Glomerular Diseases in a Tertiary Hospital in Southern Brazil

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