“…While a number of systematic reviews did not provide enough details to determine the extent to which, discussed interventions were accessible to the general patient or potential patient population, the majority [4], [9], [10], [11], [12], [14], [18], [23], [24], [29], [31], [32], [34], [48], [49], [50], [51], [63] and [64] provided information which indicated that accessibility was limited as depicted in Figure 8. Among the many mentioned factors which negatively affect accessibility were usability, integration between patients and electronic health records, and giving personalized feedback [4], [63], centralized and decentralized data problem, which is a source of confusion and poses security and privacy challenges [32], performance in clinical settings is still controversial [31] and insu cient healthcare infrastructure and funding [11], [29].…”