Natural additives for poly (hydroxybutyrate - CO - hydroxyvalerate) - PHBV: effect on mechanical properties and biodegradation

Brunel, D.; Pachekoski, Wagner Maurício; Dalmolin, Carla; Agnelli, José Augusto Marcondes

doi:10.1590/1516-1439.235613

Cited by 31 publications

(22 citation statements)

References 20 publications

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“…Unfortunately materials of different HV content are hardly available in kg scale on the market. Plasticising as an alternative strategy can be found in literature but these studies often do not compare different plasticisers [13][14][15] or investigate PHBV in combination with another biopolymer [16,17] or with another additive [18,19]. The interesting approach of this study is the comparison of different types and molecular weights of plasticisers on the PHBV.…”

Section: Introductionmentioning

confidence: 99%

Effect of different plasticisers on the mechanical and barrier properties of extruded cast PHBV films

Jost

Langowski

2015

European Polymer Journal

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Section: Introductionmentioning

confidence: 99%

Effect of different plasticisers on the mechanical and barrier properties of extruded cast PHBV films

Jost

Langowski

2015

European Polymer Journal

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“…In addition, the high stiffness and mechanical brittleness difficult processing of PHB. To achieve greater flexibility, a plasticizer can be added to increase the free volume between the polymer chains 21,22 or a copolymer of PHB, for example, polyhydroxybutyrate-cohydroxyvalerate (PHBV) can be used [23][24][25] . Another possibility to improve the performance of PHB is to use natural or synthetic fibers as reinforcing the polymeric matrix obtaining a composite [26][27][28] .…”

Section: Introductionmentioning

confidence: 99%

Polyhydroxybutyrate Composites with Random Mats of Sisal and Coconut Fibers

et al. 2016

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Biodegradable polymeric composites using natural fibers have been investigated aiming to mitigate environmental impacts. In this paper, polyhydroxybutyrate (PHB) composites obtained using random mats of sisal and coconut fibers by compression molding in a hydraulic press, and the fiber content varied between 10% and 15% relative to the weight of the polymer. Thermal analyses were performed such as Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). Flexural and tensile tests were performed before and after conditioning in climate chamber with temperature and moisture. The results of thermal analysis show that the thermal stability of the materials remained, both PHB without fiber as for composites with natural fibers mats. The results of mechanical tests indicated that the PHB without fibers and composites showed similar flexural strength values, while the results of the tensile test PHB without fibers showed resistance to higher tensile composite.

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“…In this context, the most used piezoelectric materials for tissue engineering applications belong to the poly(vinylidene fluoride) family [12] and do not possess biodegradability, which may hinder some applications [27]. Further, the other often used biomaterial, poly(l-lactic acid) (PLLA), shows a piezoelectric response, however with a slow degradation rate [12].Poly(hydroxybutyrate-co-hydroxyvalerate), PHBV, is a PHB copolymer that was developed to enhance PHB toughness and processability, widening its industrial applications [28,29]. PHBV is a biocompatible, biodegradable, highly absorbent, non-toxic thermoplastic.…”

mentioning

confidence: 99%

“…Poly(hydroxybutyrate-co-hydroxyvalerate), PHBV, is a PHB copolymer that was developed to enhance PHB toughness and processability, widening its industrial applications [28,29]. PHBV is a biocompatible, biodegradable, highly absorbent, non-toxic thermoplastic.…”

mentioning

confidence: 99%

Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications

et al. 2020

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Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a piezoelectric biodegradable and biocompatible polymer suitable for tissue engineering applications. The incorporation of magnetostrictive cobalt ferrites (CFO) into PHBV matrix enables the production of magnetically responsive composites, which proved to be effective in the differentiation of a variety of cells and tissues. In this work, PHBV and PHBV with CFO nanoparticles were produced in the form of films, fibers and porous scaffolds and subjected to an experimental program allowing to evaluate the degradation process under biological conditions for a period up to 8 weeks. The morphology, physical, chemical and thermal properties were evaluated, together with the weight loss of the samples during the in vitro degradation assays. No major changes in the mentioned properties were found, thus proving its applicability for tissue engineering applications. Degradation was apparent from week 4 and onwards, leading to the conclusion that the degradation ratio of the material is suitable for a large range of tissue engineering applications. Further, it was found that the degradation of the samples maintain the biocompatibility of the materials for the pristine polymer, but can lead to cytotoxic effects when the magnetic CFO nanoparticles are exposed, being therefore needed, for magnetoactive applications, to substitute them by biocompatible ferrites, such as an iron oxide (Fe 3 O 4 ).Polymers 2020, 12, 953 2 of 15In particular, smart polymers are gaining increasing attention as substrates and scaffolds for tissue engineering applications mainly as electroactive substrates-mostly piezoelectric ones-such as poly(l-lactic acid) (PLLA) [5,6], poly(hydroxybutyrate) (PHB) [7], poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) [8,9] and poly(vinylidene fluoride) (PVDF) [10,11], among others. The ability of those materials to actively enhance and stimulate cellular differentiation processes has been already proven [12,13], based on their mechano-transduction characteristics, generating voltage upon mechanical stimulation and vice-versa [14]. Piezoelectricity is a property that appears in a diversity of human tissues, including DNA, bones or tendons, emphasizing the relevance of electrical and mechano-electrical stimulation in physiological processes [15,16]. In a different approach to apply mechanical and/or mechano-electrical signals, magnetoelectric materials have also proven their aptness for tissue engineering applications, with the particularity of allowing electrical stimulation of the materials and, therefore, on the cells cultured on them, through magnetic solicitation [17,18]. These materials can generate voltage upon magnetic stimulation through the coupling of the magnetostrictive effect (magnetic to mechanical) and piezoelectric effect (mechanical to electric) [19,20]. Magnetoelectric composites are thus achieved combining a piezoelectric polymer with magnetostrictive particles [21][22][23], and their potential for tissue engineering and enhancement of cellular di...

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Natural additives for poly (hydroxybutyrate - CO - hydroxyvalerate) - PHBV: effect on mechanical properties and biodegradation

Cited by 31 publications

References 20 publications

Effect of different plasticisers on the mechanical and barrier properties of extruded cast PHBV films

Effect of different plasticisers on the mechanical and barrier properties of extruded cast PHBV films

Polyhydroxybutyrate Composites with Random Mats of Sisal and Coconut Fibers

Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications

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