Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres

Abstract

Poly(glycolide-co-lactide) (PLGA) nanospheres containing magnetic materials have been extensively studied because of its biomedical applications. Therefore, it is very important to know thermal properties of these materials in addition to other physical properties. Thermal degradation activation energy (E α ) of PLGA nanospheres with maghemite entrapment (PLGA-Mag), PLGA nanospheres (hollow spheres) (PLGA-H) obtained by an emulsion method and unprocessed PLGA (PLGA-R) were calculated by isoconversional Vyazovkin method based on data of TG analysis in order to evaluate modifications in thermal behavior caused by nanospheres obtainment process or by maghemite entrapment. Both hydrodynamic diameter in the range of 200-250 nm and polydispersity index lower than 0.3 are considered satisfactory. Thermal degradation of PLGA-R begins at higher temperatures than those of PLGA-H and PLGA-Mag, but processed samples presented increase in thermal stability, which was greater before processing by emulsion and in the presence of the magnetic materials. PLGA-Mag presents superparamagnetic behavior at room temperature.

Preparation, Characterization and In vitro Biological activity of 5-Fluorouracil Loaded onto poly (D, L-lactic-co-glycolic acid) Nanoparticles

“…PLGA was thermal stable until 200 °C with a weight loss of 3.88%, after which it decomposed in one step from 200 to 380 °C with a weight loss of 3.03%. The degradation products of PLGA are similar to those of poly(lactide) and poly(glycolide) polymers in their pure state [52]. Fig.…”

Fe3O4 @ PLGA‐PEG Nanocomposite for Improved Delivery of Methotrexate in Cancer Treatment

“…In PP thermal decomposition initially is obtained due to loss of residual moisture followed by pyrolisis temperature appearing around 200°C. Further weight loss is obtained in the region of 300‐600°C due to thermal decomposition of chain and branch bonding in polymer . The TGA curve of FPP NC showed no weight loss upto 250°C.…”

Sonochemical coating as an effective method of polymeric nonwovens functionalization

“…A possible explanation for this observation is that interaction between PLA–PGA chains is stronger than between PLA–PLA chains. PLGA degradation mechanism involves a random chain scission at the beginning of the decomposition and specific chain scission at the end (Silva, et al, ). Additionally in case of samples with HAp, a peak between 100 and 450°C contributes to the loss of lattice water (Suchanek et al, ; Suchanek & Yoshimura, ), however, it is not seen in our case.…”