Resveratrol reduces chronic inflammation and improves insulin action in the myocardium of high-fat diet-induced obeserats

Abstract

A B S T R A C T ObjectiveTo evaluate the effects of resveratrol on insulin signaling and inflammation pathway in the myocardium of high-fat diet-induced obese rats. MethodsThirty Wistar rats were divided into a control group (n=10, standard diet), obese group (n=10, high-fat diet), and obese supplemented with resveratrol group (n=10, 20 mg/kg/day) for eight weeks. An insulin tolerance test was performed at the end of the study period "0" (without insulin), 5, 10, 15, 20, 25, and 30 minutes after an intraperitoneal injection of insulin (2 U/kg). Body and epididymal adipose tissue were weighed. Fragments of the myocardium were extracted for Western blot analyses of insulin pathway and proinflammatory molecules. ResultsResveratrol increased the rate of glucose disappearance, phosphorylation of the insulin receptor, insulin receptor substrate 1, and protein kinase B; and reduced expression of tumor necrosis factor alpha and of the molecules

Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart

“…This molecule has shown pleiotropic and beneficial effects on both type 2 diabetes and cardiovascular complications [9]. Various studies, using models of type 2 diabetes or metabolic syndrome, showed that RSV could decrease chronic inflammation [10], improve insulin sensitivity [11], lipid profile [12], and decrease oxidative stress [13]. Other studies also demonstrated the effects of RSV on endothelial function mainly through mechanisms involving nitric oxide (NO) and sirtuin pathways [14,15,16,17].…”