Selective inhibition of interleukin 6 receptor decreased inflammatory cytokines and increased proteases in an experimental model of critical calvarial defect
R.C.O. Melo,
A.A. Martins,
G.H.A. Vieira
et al.
Abstract:Considering the lack of consensus related to the impact of selective IL-6 receptor inhibition on bone remodeling and the scarcity of reports, especially on large bone defects, this study proposed to evaluate the biological impact of the selective inhibitor of interleukin-6 receptor (tocilizumab) in an experimental model of critical calvarial defect in rats. In this preclinical and
in vivo
study, 24 male Wistar rats were randomly divided into two groups (n=12/group): defect treated with c… Show more
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