Which detergent is most suitable for the generation of an acellular pancreas bioscaffold?
M.C. Mantovani,
N.R. Damaceno-Rodrigues,
G.T.S. Ronatty
et al.
Abstract:Pancreatic bioengineering is a potential therapeutic alternative for type 1 diabetes (T1D) in which the pancreas is decellularized, generating an acellular extracellular matrix (ECM) scaffold, which may be reconstituted by recellularization with several cell types to generate a bioartificial pancreas. No consensus for an ideal pancreatic decellularization protocol exists. Therefore, we aimed to determine the best-suited detergent by comparing sodium dodecyl sulfate (SDS), sodium deoxycholate (SDC), and Triton … Show more
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