2023
DOI: 10.1590/1414-431x2023e12970
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A bioinformatic analysis of the role of TP53 status on the infiltration of CD8+ T cells into the tumor microenvironment

A.A. El-Arabey,
H.E. Abdel-Hamied,
M.E. Awadalla
et al.

Abstract: CD8 + T cells play basic roles in the immune system in a tumor microenvironment (TME) to fight cancer. Several reports have suggested signs of the involvement of tumor protein p53 (TP53) in a complex immune system network. Moreover, our previous research indicated that TP53 orchestrates the polarization and infiltration of macrophages into the TME. In the present study, the clinical function of TP53 status (wild/mutant) in CD8 + T cell infiltration was assessed usi… Show more

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