Effect of COVID-19 on cardiorenal axis: known or unknown universe?

Abstract

Recent findings have confirmed relationships between coronavirus disease (COVID-19) and multiple organ dysfunction. The prevalence of cardiac and renal involvement in COVID-19 has been increasingly reported and is a marker of severe disease that not only directly or indirectly affects the organs, but may also exacerbate the underlying comorbid illness. In addition, patients affected by the new coronavirus present a systemic inflammatory condition that results in damage to several tissues, especially the heart, kidneys, and vessels. It is well known that the heart and kidneys are closely related, so that any change in one of the organs can lead to damage to the other, establishing the so-called cardiorenal syndrome. Herein, we explore some case reports of patients with COVID-19 who had heart and kidney abnormalities, consequently resulting in worse prognosis of the disease. These results highlight the importance of understanding the cause and effect between the cardiac and renal systems and the course of early SARS-CoV-2 infection.

A systematic review and meta‑analysis of Arbidol therapy for acute respiratory viral infections: A potential treatment for COVID‑19

“…According to the World Health Organization report, Corona Virus Disease 2019 (COVID- 19) has infected >514 million patients and resulted in >6 million deaths worldwide (as of May 6, 2022). SARS-CoV-2 can affect multiple organs, which can lead to severe disease in patients with underlying comorbidities (5). Given the rapid emergence and global spread, reducing SARS-CoV-2 infection and increasing recovery rate are critical.…”