Progress in the photodynamic therapy treatment of Leishmaniasis

Vital-Fujii, D.G.; Baptista, Maurı́cio S.

doi:10.1590/1414-431x2021e11570

Cited by 9 publications

(4 citation statements)

References 66 publications

(121 reference statements)

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“…It should be noted that this low toxicity of ICG was also reported by other researchers (17,40). On the other hand, one of the main advantages of ICG over porphyrins is its minimal absorption in the 400-600 nm range, which results in lower phototoxicity on the skin (41).…”

Section: Discussionsupporting

confidence: 80%

Photo-induced antileishmanial activity of indocyanine green: In vitro and in vivo studies

Jalili,

Sazgarnia,

Hoseini

2023

Preprint

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Background Indocyanine green is a promising dye for photodynamic and photothermal therapy. However, ICG tends to aggregate in aqueous media, which limits its use in light therapy. Loading ICG onto a biocompatible structure can improve its aqueous stability. The aim of this study was to investigate the synergistic effect of PDT/PTT on leishmanial activity in the presence of micelles loaded with ICG. Methods After synthesizing micelles containing ICG, the dark toxicity of the pharmaceutical agents and in vitro phototoxicity by a cw 808 nm laser on promastigotes were determined via MTS assay. Finally, the efficacy of the treatments was assessed by measuring the diameter of the lesion every three days in a study conducted on 33 female BALB/c mice aged 4-6 weeks. Results At 808 nm, the absorbance of ICG inside the micelles was approximately2.5 times that of free ICG. The optimal concentration of ICG was determined to be 100 μM based on the toxicity of the medicinal agents topromastigotes. In the in vitro experiment, the groups containing ICG showed a significant decrease in survival compared to the control group with increasing light dose. In the animal model study, the simultaneous presence of medicinal agents and the application of a laser created a significant difference in the relative area of the lesion compared to the control group. Conclusion The findings of this study show that PTT/PDT mediated by ICG can be considered an inexpensive, safe, easy to administer and efficient treatment against Leishmania L. major both in vitro and in vivo. Moreover, this treatment does not cause any adverse effects when compared to other treatments.

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Section: Discussionsupporting

confidence: 80%

Photo-induced antileishmanial activity of indocyanine green: In vitro and in vivo studies

Jalili,

Sazgarnia,

Hoseini

2023

Preprint

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“…Since antimicrobial photodynamic therapy (aPDT) was first applied over a century ago, there have been ever-expanding number of studies in the literature that demonstrate the feasibility and efficacy of aPDT against several pathogenic microbes of clinical importance [ 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. Within the aPDT field, many photosensitizers and wavelengths have been applied to harness their antimicrobial potential.…”

Section: Light-based Anti-infective Agents: Can They Overcome Antimic...mentioning

confidence: 99%

Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

Leanse,

Marasini,

dos Anjos

et al. 2023

Antibiotics

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In recent years, with the increases in microorganisms that express a multitude of antimicrobial resistance (AMR) mechanisms, the threat of antimicrobial resistance in the global population has reached critical levels. The introduction of the COVID-19 pandemic has further contributed to the influx of infections caused by multidrug-resistant organisms (MDROs), which has placed significant pressure on healthcare systems. For over a century, the potential for light-based approaches targeted at combatting both cancer and infectious diseases has been proposed. They offer effective killing of microbial pathogens, regardless of AMR status, and have not typically been associated with high propensities of resistance development. To that end, the goal of this review is to describe the different mechanisms that drive AMR, including intrinsic, phenotypic, and acquired resistance mechanisms. Additionally, the different light-based approaches, including antimicrobial photodynamic therapy (aPDT), antimicrobial blue light (aBL), and ultraviolet (UV) light, will be discussed as potential alternatives or adjunct therapies with conventional antimicrobials. Lastly, we will evaluate the feasibility and requirements associated with integration of light-based approaches into the clinical pipeline.

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“…Medication used for CL treatment includes the administration of pentavalent antimonials such as Pentosan® and Glucantime®, or Amphotericin B in more severe cases [162]. However, these drugs are known for their wide range of adverse side effects such as nausea, vomiting, hepatic alterations, and cardiac disorders, among others, combined with an increasing rate of drug resistance [163].…”

Section: Antiparasitic Pdtmentioning

confidence: 99%

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

F Isaac-Lam,

Nguyen

2023

TTU J Biomed Sci

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Photodynamic therapy (PDT) or light treatment is a procedure to treat certain types of diseases that uses a photosensitizer (PS) which upon light activation produces cytotoxic oxygen species destroying tumor cells. PDT is minimally-invasive and can be repeated a few times without accumulating significant toxicity in the surrounding tissues. While PDT application in cancer treatment is well established and widely recognized by the scientific community, and its use in the fight against microbial infection is gaining momentum with the rapid increase in antimicrobial multi-drug resistance, its use in the treatment of cardiovascular diseases is clearly marginal. This mini-review presents a brief historical background of PDT, photo-activatable agents utilized, mechanism of photodynamic action, studies in vitro and in vivo, clinical trials, limitations and future prospects of its application in various types of cancer, infections caused by pathogens such as COVID-19, and heart diseases.

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Progress in the photodynamic therapy treatment of Leishmaniasis

Cited by 9 publications

References 66 publications

Photo-induced antileishmanial activity of indocyanine green: In vitro and in vivo studies

Photo-induced antileishmanial activity of indocyanine green: In vitro and in vivo studies

Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

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