Association of quality of life and disease control with cigarette smoking in patients with severe asthma

Santos, Vanessa; Moreira, Maria Angela Fontoura; Junior, Arlino Rosa; Sobragi, S.M.; Silva, C.A.J. da; Dalcin, Paulo de Tarso Roth

doi:10.1590/1414-431x2021e11149

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…These findings suggest that most asthma patients continue to smoke until they experience significant symptoms of wheezing, discomfort and shortness of breath. Several studies have found that smoking contributes to increased morbidity and mortality, exacerbation of symptoms and frequent hospitalizations in asthmatic patients [14][15][16] . At the same time, asthmatics in the smoking group had more frequent asthma attacks, an increased number of life-threatening asthma attacks, and a higher mortality rate among heavy smokers compared to asthmatic non-smokers [17][18][19] .…”

Section: Discussionmentioning

confidence: 99%

Different clinical characteristics of current smokers and former smokers with asthma: a cross-sectional study of adult asthma patients in China

Chen

Wasti

Shang

et al. 2023

Sci Rep

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Smoking is a trigger for asthma, which has led to an increase in asthma incidence in China. In smokers, asthma management starts with smoking cessation. Data on predictors of smoking cessation in Chinese patients with asthma are scarce. The objective of this study was to find the differences in clinical characteristics between current smokers and former smokers with asthma in order to identify factors associated with smoking cessation. Eligible adults with diagnosed asthma and smoking from the hospital outpatient clinics (n = 2312) were enrolled and underwent a clinical evaluation, asthma control test (ACT), and pulmonary function test. Information on demographic and sociological data, lung function, laboratory tests, ACT and asthma control questionnaire (ACQ) scores was recorded. Patients were divided into a current smokers group and a former smokers group based on whether they had quit smoking. Logistic regression analysis was used to analyze the factors associated with smoking cessation. Of all patients with asthma, 34.6% were smokers and 65.4% were former smokers, and the mean age was 54.5 ± 11.5 years. Compared with current smokers, the former smokers were older, had longer duration of asthma, had higher ICS dose, had more partially controlled and uncontrolled asthma, had more pack-years, had smoked for longer, and had worse asthma control. The logistic regression model showed that smoking cessation was positively correlated with age, female sex, pack-years, years of smoking, partially controlled asthma, uncontrolled asthma, and body mass index (BMI), but was negatively correlated with ACT, FEV1, FEV1%predicted, and widowed status. More than 30% of asthma patients in the study were still smoking. Among those who quit smoking, many quit late, often not realizing they need to quit until they have significant breathing difficulties. The related factors of smoking cessation identified in this study indicate that there are still differences between continuing smokers and former smokers, and these factors should be focused on in asthma smoking cessation interventions to improve the prognosis of patients with asthma.

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Section: Discussionmentioning

confidence: 99%

Different clinical characteristics of current smokers and former smokers with asthma: a cross-sectional study of adult asthma patients in China

Chen

Wasti

Shang

et al. 2023

Sci Rep

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Asthma control and sputum eosinophils in adult patients: a cross-sectional study in southern Brazil

Barcellos,

dos Santos,

Moreira

et al. 2023

Sci Rep

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Asthma control and health related quality of life are an important goal of asthma management, but their association with sputum eosinophilic inflammation has been less firmly established. To investigate the relationship of asthma control and quality of life with sputum eosinophils in clinical practice. Cross-sectional study with a convenience sample, including patients with asthma, aged between 18 and 65 years, attending to outpatient clinic. Patients underwent sputum induction, pulmonary function tests, Juniper’s Asthma Quality of Life Questionnaire (AQLQ), Asthma Control Test (ACT), Global Initiative for Asthma (GINA) criteria for evaluation of asthma control and severity of the disease, blood count analysis, serum IgE and cutaneous prick test. Sputum sample was considered as eosinophilic if the percentage of eosinophils was ≥ 3%. A total of 45 individuals were enrolled, 15 with eosinophilic sputum (≥ 3% eosinophil cells) and 30 with non-eosinophilic sputum (< 3% eosinophil cells). There were no association of ACT an AQLQ scores with sputum eosinophilia (p > 0.05). This study suggested that the finding of sputum eosinophilia was not related to asthma control neither with health-related quality of life in patients with severe asthma.

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A Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System

Wang¹,

Wang²,

Chen³

et al. 2022

IJMS

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Electronic cigarettes (e-cigarettes) have attracted much attention as a new substitute for conventional cigarettes. E-cigarettes are first exposed to the respiratory system after inhalation, and studies on the toxicity mechanisms of e-cigarettes have been reported. Current research shows that e-cigarette exposure may have potentially harmful effects on cells, animals, and humans, while the safety evaluation of the long-term effects of e-cigarette use is still unknown. Similar but not identical to conventional cigarettes, the toxicity mechanisms of e-cigarettes are mainly manifested in oxidative stress, inflammatory responses, and DNA damage. This review will summarize the toxicity mechanisms and signal pathways of conventional cigarettes and e-cigarettes concerning the respiratory system, which could give researchers a better understanding and direction on the effects of e-cigarettes on our health.

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Association of quality of life and disease control with cigarette smoking in patients with severe asthma

Cited by 3 publications

References 33 publications

Different clinical characteristics of current smokers and former smokers with asthma: a cross-sectional study of adult asthma patients in China

Different clinical characteristics of current smokers and former smokers with asthma: a cross-sectional study of adult asthma patients in China

Asthma control and sputum eosinophils in adult patients: a cross-sectional study in southern Brazil

A Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System

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