Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer

Fu, Ping; Lin, Liangqing; Zhou, Hui; Zhao, Sijun; Jie, Zhigang

doi:10.1590/1414-431x2020e10940

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…Examination of miRNAs for specific fractions can significantly increase both the sensitivity and specificity of selected circulating miRNAs as noninvasive biomarkers [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ].…”

Section: Circulating Mirnamentioning

confidence: 99%

miRNAs in Cancer (Review of Literature)

Smolarz

Durczyński

Romanowicz

et al. 2022

IJMS

121

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MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the course of processes of fundamental importance for the proper functioning of the organism. These processes include cell division, proliferation, differentiation, cell apoptosis and the formation of blood vessels. Altered expression of individual miRNAs has been shown in numerous cancers, which may indicate the oncogenic or suppressor potential of the molecules in question. This paper discusses the current knowledge about the possibility of using miRNA as a diagnostic marker and a potential target in modern anticancer therapies.

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Section: Circulating Mirnamentioning

confidence: 99%

miRNAs in Cancer (Review of Literature)

Smolarz

Durczyński

Romanowicz

et al. 2022

IJMS

121

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show abstract

“…Many studies of cancer reported that miR-106a-5p was overexpressed in tumor and diminished GASL1's roles in cell proliferation and metastasis. Whereas GASL1 inhibited GC cell proliferation and metastasis via targeting and blocking PI3K/AKT ras/raf/MEK/ERK pathways [13][14][15] indicating role of miR-106a-5p as tumor oncogene. miR-106a-5p up-regulation is strongly correlated with invasion, lymphatic and distant metastasis, tumor stage, size, and differentiation [16].…”

Section: Discussionmentioning

confidence: 99%

microRNA profiling of Iraqi patients with gastric cancer

Hasan

Safaralizadeh

Khalaj‐Kondori

2022

Preprint

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Background: Gastric cancer has the fifth place commonly identified malignancy and third principal cause of cancer-related fatalities globally, with over 1 million cases globally. Since each miRNAs regulates multiple target mRNAs that participate in a variety of biological processes, including signal transduction, cell differentiation, apoptosis, and proliferation, totaling 30% of protein-coding genes. Thus, deregulation of miRNAs has a role in a variety of clinical diseases, including GC and characterize a developing field of cancer research. The goal of this study was to investigate the signature of miRNA profile in Iraqi patients with gastric cancer. Methods: One-hundred tissue specimens include 50 cancerous tissues and 50 normal tissues from 50 patients were collected for miRNA profiling by microarray assay. Results Our results exhibited that 37 miRNAs were up-regulated in patients with gastric cancer (P <0.05), and 40 miRNAs were down-regulated in patients with gastric cancer (P <0.05). Then, 3 highly overexpressed miRNAs (miR-221-3p, miR-106a-5 and miR-21-5p) were chosen for further validated by Real-Time polymerase chain reaction. In the validation set, the level of (miR-106a-5, miR-21-5p and miR-221-3p) were tested by qRT-PCR have significant up-regulation in GC related to normal tissues (P <0.05). Conclusions: According to our present findings, the 3 miRNAs (miR-106a-5, miR-21-5p and miR-221-3p) strongly suggested involvement in gastric carcinogenesis, hence highlighting its serving as promising prognostic, diagnostic biomarkers or therapeutic targets for gastric cancer patients.

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“…The most overexpressed candidate, particularly in GBM-REC tumors, is circEGFR. CircEGFR is derived from the EGFR gene which is a well-established oncogene in various cancers [66, 67]. In contrast, circEFGR was also found as an inhibitor of the malignant progression of glioma by regulating the levels of miR-183-5p and TUSC2 [68].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Transcriptome-wide analysis of circRNA and RBP profiles and their molecular and clinical relevance for GBM

Latowska-Łysiak,

Zarębska,

Sajek

et al. 2024

Preprint

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Glioblastoma (GBM) is the most aggressive and lethal type of glioma, characterized by aberrant expression of non-coding RNAs including circular RNAs (circRNAs). They might impact cellular processes by interacting with other molecules – like microRNAs or RNA-binding proteins (RBPs). The diagnostic value of circRNAs and circRNAs/RBPs complexes is still largely unknown. To explore circRNAs and RBPs transcripts expression in GBM, we performed and further analyzed RNA-seq data from GBM patients’ primary and recurrent tumor samples. We identified circRNAs differentially expressed in primary tumors, the circRNA progression markers in recurrent GBM samples as well as the expression profile of RBP transcripts. Subsequent analysis allowed us to generate a comprehensive catalog of circRNA-RBP interactions regarding both the RBPs sequestration by circRNA as well as the RBPs involvement in circRNA biogenesis. Furthermore, we demonstrated the clinical potential of circRNAs and RBPs in GBM and proposed them as the stratification markers in the de novo assembled tumor subtypes. Therefore, our transcriptome-wide study specified circRNA-RBP interactions that could play a significant regulatory role in gliomagenesis and GBM progression.

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Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer

Cited by 7 publications

References 38 publications

miRNAs in Cancer (Review of Literature)

miRNAs in Cancer (Review of Literature)

microRNA profiling of Iraqi patients with gastric cancer

Transcriptome-wide analysis of circRNA and RBP profiles and their molecular and clinical relevance for GBM

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