Steroidal saponins from the roots of Solanum sisymbriifolium Lam. (Solanaceae) have inhibitory activity against dengue virus and yellow fever virus

Figueiredo, Glauciane Garcia de; Coronel, Oscar Andrés Del Ángel; Trabuco, Amanda Cristina; Bazán, D.; Russo, Raquel Rinaldi; Alvarenga, Nelson; Aquino, Víctor Hugo

doi:10.1590/1414-431x2020e10240

Cited by 15 publications

(8 citation statements)

References 35 publications

(41 reference statements)

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“…Few studies have used bacteriophages to evaluate the antiviral activity of plant extracts; generally, assays are done using HeLa and Vero cell lines [77,78]. Several studies have examined the efficacy of extracts of other species of the Solanum genus against different viral elements that cause consequential human diseases such as the herpes simplex virus (HSV) [79], dengue virus (DENV), yellow fever virus (YFV) [80], and hepatitis B and C virus (HBV and HCV, respectively). We expected the fruit to have antiviral properties because of its high solamargine content [38], unlike the leaves and essential oil, which do not contain alkaloids.…”

Section: Discussionmentioning

confidence: 99%

High in vitro activity of gold and silver nanoparticles from Solanum mammosum L. against SARS-CoV-2 surrogate Phi6 and viral model PhiX174

et al. 2023

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The search for new strategies to curb the spread of the SARS-CoV-2 coronavirus, which causes COVID-19, has become a global priority. Various nanomaterials have been proposed as ideal candidates to inactivate the virus; however, because of the high level of biosecurity required for their use, alternative models should be determined. This study aimed to compare the effects of two types of nanomaterials—gold (AuNPs) and silver nanoparticles (AgNPs), recognized for their antiviral activity and affinity with the coronavirus spike protein—using PhiX174 and enveloped Phi6 bacteriophages as models. To reduce the nanoparticles' toxicity, a species known for its intermediate antiviral activity, Solanum mammosum L. (Sm), was used. NPs prepared with sodium borohydride (NaBH4) functioned as the control. Antiviral activity against PhiX174 and Phi6 was analyzed using its seed, fruit, leaves, and essential oil; the leaves were the most effective on Phi6. Using the aqueous extract of the leaves, AuNPs-Sm of 5.34 ± 2.25 nm and AgNPs-Sm of 15.92 ± 8.03 nm, measured by transmission electron microscopy (TEM), were obtained. When comparing NPs with precursors, both gold(III) acetate and silver nitrate were more toxic than their respective NPs (99.99% at 1 mg/mL). The AuNPs-Sm were less toxic, reaching 99.30% viral inactivation at 1 mg/mL, unlike the AgNPs-Sm, which reached 99.94% at 0.01 mg/mL. Gallic acid was the main component identified in the leaf extract using high performance liquid chromatography with diode array detection (HPLC-DAD). The FT-IR spectra showed the presence of a large proportion of polyphenolic compounds, and the antioxidant analysis confirmed the antiradical activity. The control NPs showed less antiviral activity than the AuNPs-Sm and AgNPs-Sm, which was statistically significant; this demonstrates that both the S. mammosum extract and its corresponding NPs have a greater antiviral effect on the surrogate Phi bacteriophage, which is an appropriate model for studying SARS-CoV-2.

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Section: Discussionmentioning

confidence: 99%

High in vitro activity of gold and silver nanoparticles from Solanum mammosum L. against SARS-CoV-2 surrogate Phi6 and viral model PhiX174

et al. 2023

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“…For the first mechanism, BBR was shown to have a direct inhibitory activity against the DENV virion, (as well as towards ZIKV and CHIKV), while in the second mechanism BBR exerted a cellular effect that served to reduce DENV production. A number of other natural compounds have been shown to exert a direct inhibitory effect on DENV, including baicalein [41,42], some steroidal saponins [43], betacyanins [44] and geraniin [45]. The mechanisms of action of such inhibitory compounds generally remains poorly characterized, but compounds could inhibit by binding directly to E protein and blocking receptor attachment, blocking the low pH mediated rearrangement of E protein required for endosomal membrane fusion, or by directly affecting the virion phospholipid membrane as has been recently shown for the lantibiotic Labyrinthopeptin A1 [46].…”

Section: Discussionmentioning

confidence: 99%

Berberine Inhibits Dengue Virus through Dual Mechanisms

et al. 2021

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Mosquito transmitted viruses, particularly those of the genus Flavivirus, are a significant healthcare burden worldwide, especially in tropical and sub-tropical areas. However, effective medicines for these viral infections remains lacking. Berberine (BBR) is an alkaloid found in some plants used in traditional medicines in Southeast Asia and elsewhere, and BBR has been shown to possess anti-viral activities. During a screen for potential application to mosquito transmitted viruses, BBR was shown to have virucidal activity against dengue virus (DENV; IC50 42.87 µM) as well as against Zika virus (IC50 11.42 µM) and chikungunya virus (IC50 14.21 µM). BBR was shown to have cellular effects that lead to an increase in cellular DENV E protein without a concomitant effect on DENV nonstructural proteins, suggesting an effect on viral particle formation or egress. While BBR was shown to have an effect of ERK1/2 activation this did not result in defects in viral egress mechanisms. The primary effect of BBR on viral production was likely to be through BBR acting through AMPK activation and disruption of lipid metabolism. Combined these results suggest that BBR has a dual effect on DENV infection, and BBR may have the potential for development as an anti-DENV antiviral.

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“…Figueiredo et al isolated steroidal saponins from the roots of Solanum sisym-Lam. (Solanaceae)which showed a response against dengue virus and yellow fever virus [34]. Chlorogenone, (5α,25S)-Spirostan-3,6-dione are isolated from Solanum torvum Sw. Nuatigenosido isolated from S. sisymbriifolium Lam.…”

Section: Saponins In the Solanaceae Familymentioning

confidence: 99%

Phytochemicals from Solanaceae Family and Their Anticancer Properties

Yadav¹,

Koshi²

2022

Medicinal Plants

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Cancer is one of the most dreadful disease conditions all over the world. With the side effects and cost of conventional treatment, there is a demand for new therapies to prevent cancer. Research studies proved many plant products possess anticancer properties. Currently, a few plant-based drugs are used to treat it. The phytochemicals are investigated by in vitro and in vivo to assess their mechanism of action against cancer. This chapter is an overview of anticancer compounds extracted from plants of Solanaceae family with the potentials results. Many research has confirmed the anticancer efficiency of the biomolecules, such as solanine, solamargine, tomatidine, Withanolides, scopoletin, capsaicin found in Solanaceae, and their mode of action, such as cell cycle arrest, inhibiting signaling pathways, autophagy, suppression of enzymes in various human cancer cell lines of breast, pancreas, colorectal, liver, and cervical and also in animal models. This chapter seeks to provide an outline of key examples of anticancer activity of phytochemicals from the Solanaceae family, which offers a track for the development of novel medicines for cancer treatment as a single drug or in combinational drug. This chapter helps to identify the novel bioactive molecule for cancer treatment as lead molecule with less side effects in future.

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Steroidal saponins from the roots of Solanum sisymbriifolium Lam. (Solanaceae) have inhibitory activity against dengue virus and yellow fever virus

Cited by 15 publications

References 35 publications

High in vitro activity of gold and silver nanoparticles from Solanum mammosum L. against SARS-CoV-2 surrogate Phi6 and viral model PhiX174

High in vitro activity of gold and silver nanoparticles from Solanum mammosum L. against SARS-CoV-2 surrogate Phi6 and viral model PhiX174

Berberine Inhibits Dengue Virus through Dual Mechanisms

Phytochemicals from Solanaceae Family and Their Anticancer Properties

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