Abstract:The objective of this study was to investigate the effect of Mycobacterium vaccae on Jagged 1 and gamma delta T17 (gdT17) cells in asthmatic mice. An asthma mouse model was established through immunization with ovalbumin (OVA). Gammasecretase inhibitor (DAPT) was used to block the Notch signaling pathway. M. vaccae was used to treat asthma, and related indicators were measured. Blocking Notch signaling inhibited the production of gdT17 cells and secretion of cytokine interleukin (IL)-17, which was accompanied … Show more
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