Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients

Abstract

This study aimed to investigate the predictive factors for uveitis recurrence (UR) risk in Behcet's disease (BD) patients. BD patients (n=164) with a history of uveitis were recruited, and demographic data, clinical features, and laboratory tests were recorded. Uveitis was defined as anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis referring to the ''International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease''. In total, there were 70 UR patients and 94 non-UR patients. Compared to non-UR patients, UR patients appeared to be older and presented with increased uveitis occurrence rate and times within 3 months, oral ulcers occurrence rate, as well as higher concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and serum amyloid A (SAA). Multivariate logistic model disclosed that uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA independently predicted higher risk of UR. Furthermore, receiver operating characteristic curve analysis showed that the combination of uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA exhibited a high predictive value for UR risk with an area under the curve of 0.983 (95%CI: 0.969-0.998). In conclusion, uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA might be potential predictive factors for UR risk in BD patients, which can help in prevention and management of the disease.

The Application of Artificial Intelligence in the Analysis of Biomarkers for Diagnosis and Management of Uveitis and Uveal Melanoma: A Systematic Review

“… DIMS2 Cohort: (B27-AAU 67%/33%, Idiopathic AAU 50%/50%, CAT 50%/50%). LC-MS/MS (B27-AAU 67%/33%, Idiopathic AAU 0%/100%, CAT 0%/100%) Wang (2019) 16 Retrospective Cross-sectional China 24 (12 controls) 51.3 ± 9.9 5/7 Cai (2020) 26 Retrospective Cross-sectional China 164 (94 controls) 33.11 ± 5.97 63/27 Sun (2016) 21 Retrospective Cross-sectional China 400 (352 controls) 33.8 ± 0.7 31/7 Xu (2021) 15 Retrospective Cross-sectional China 45 (15 VKH, 15 BD, 15 cataract controls) VKH: 45.8 ± 9.79 BD: 35.93 ± 10.72 VKH: 8/7 BD: 9/6 Bonacini (2020) 24 Retrospective Cohort Italy 30 (10 VKH, 10 BD, 10 cataract controls) BD: median 30 yrs VKH: median 47 yrs BD: 8/2 VKH: 1/9 Young (2009) 13 Prospective Cohort UK 42 (20 CU, 16 panuveitis, 2 sarcoidosis, 2 intermediate uveitis, 2 Fuchs’ heterochromic cyclitis, 9 lens-induced uveitis, 2 proliferative diabetic retinopathy, 2 proliferative vitreoretinopathy, 7 rhegmatogenous retinal detachment, 1 Candida endophthalmitis, 1 Varicella Zoster virus acute retinal necrosis) Unknown Unknown Fabiani (2018) 27 Prospective Cohort Italy 45 (32 anti-TNF-α treatment for more than 48 months, 13 patients discontinued treatment before 24 months) 44.16 ± 11.37 25/20 Abbreviations ...…”

“…Supervised Machine Learning: OPLS-DA Bioinformatics: Pathway Analysis and KEGG 3-Hydroxybutyric acid, antivirus IgG, allose, alpha-ketoisovaleric acid, etc. (14 metabolites) Cai (2020) 26 Uveitis Disease prognosis Serum Cytokines, lipids, electrolytes 17 SPSS 21.0 Supervised Regression: Univariate logistic regression, forward stepwise (conditional), multivariate logistic regression Triglycerides, total cholesterol, low-density lipoprotein, and serum amyloid A Sun (2016) 21 Uveitis Differentiating between different diseases, Serum Cytokines, chemokines, antibody 16 SPSS (Ver 22.0, Chicago, IL) Supervised Regression: Logistic regression CIC, ASO Xu (2021) 15 Uveitis Disease profile Serum Metabolites 84 SIMCA-P 14.1 1. Supervised Regression: Univariate logistic regression 2.…”

“… 16 The remaining studies used regression methods to determine treatment outcomes and prognosis. 21 , 24 , 26 , 27 …”

Clinical Manifestations, Outcomes, and Histopathology of Recurrent Uveitis in Patients Underwent Pupil Coroplasty Combined with Cataract Surgery

“…Conventional immunomodulatory agents are added as second-line therapy utilized for their durable control of ocular in ammation and as a steroid-sparing agent [24]. However, uveitis is easy to relapse even after effective treatment due to the reappearance of infectious organisms and the localization of immune complexes in the uveal tract [3,14].…”

Therapeutic potential of pupil coroplasty combined with phacomulsification and intraocular lens implantation against uveitis-induced cataract

“…Conventional immunomodulatory agents are added as second-line therapy utilized for their durable control of ocular in ammation and as a steroid-sparing agent [9]. However, uveitis is easy to relapse even after effective treatment due to the reappearance of infectious organisms and the localization of immune complexes in the uveal tract [10,11].…”