High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil

Batista, Aline Priscila; Barbosa, Keila Furbino; Masioli, Cássio Zumerle; Queiroz, Erica Maria de; Marinho, Carolina Coimbra; Cândido, Ana Paula Carlos; Machado-Coelho, George Luiz Lins

doi:10.1590/1414-431x20209113

Cited by 2 publications

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References 33 publications

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“…A mixture of Europeans, Africans, and Amerindians make up the population of Ouro Preto, found in the state of Minas Gerais in southeast Brazil [16,17]. Ouro Preto has studied its adult and child population over the years, and the data show a high prevalence of dyslipidemia and other risk factors such as excess weight [18][19][20][21]. Furthermore, current lifestyles have left children and adolescents with a greater tendency towards sedentary [22].…”

Section: Introductionmentioning

confidence: 99%

XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto Study

Souza

Batista

Júnior

et al. 2023

Preprint

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Purpose: Atherosclerotic vascular changes can begin during childhood, providing a favorable environment for the onset of cardiovascular disease (CVD) in adulthood. Identifiable risk factors such as dyslipidemia accelerate this process for some children. The apolipoprotein B (APOB) gene could help explain the inter-individual variability in lipid levels among young individuals and identify groups that require greater attention to prevent cardiovascular problems in adulthood. However, there is few research on genetic risk factors for dyslipidemia in young individuals from mixed-race groups. Methods: A cross-sectional study was conducted with elementary school students aged 6 to 17 in Ouro Preto, Minas Gerais, between April and December 2021. The study evaluated sociodemographic, behavioral, clinical, and biochemical variables and XbaI polymorphism in the APOB gene for associations with increased cholesterol. Results: The study found that the prevalence of increased cholesterol was notably high, reaching 68.9% in the study population. Carriers of the variant T allele were 1.45 times more likely to develop increased cholesterol in a dominant model (CI: 1.09-1.94). After adjustments, excess weight and a family history of dyslipidemia interacted significantly with XbaI polymorphism in increased cholesterol, resulting in Odds Ratio of 1.74 (CI: 1.11-2.71) and 2.04 (CI: 1.14-3.67), respectively. Conclusions: The results suggest that XbaI polymorphism in the APOB gene may affect the lipid profile of Brazilian children and adolescents living in urban areas and could contribute to the development of atherosclerosis and, consequently, CVD in adulthood.

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