Enhanced anti-tumor efficacy of 5-aminolevulinic acid-gold nanoparticles-mediated photodynamic therapy in cutaneous squamous cell carcinoma cells

Yu-fei, Chi; Qin, Jingjing; Li, Zhi; Ge, Qi; Zeng, Weihui

doi:10.1590/1414-431x20208457

Cited by 29 publications

(20 citation statements)

References 38 publications

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“…Numerous studies have proven that photosensitizers could be remarkarbly upgraded with better efficiencies under nanotechnological assistance, either in terms of physicochemical properties or biological activity [ 52 ]. For instance, laboratory research indicated that the employment of poly-(lactic-co-glycolic acid) or metal-based nanoparticles as delivery carriers enhanced the uptake of 5-ALA and the following PpIX conversion, which therefore promoted its efficacy [ 53 , 54 , 55 , 56 ]. In a registered 5-ALA gel, 5-ALA was loaded into a nanoscale-lipid vesicle for the treatment of actinic keratosis.…”

Section: Resultsmentioning

confidence: 99%

Evolutionary Trend Analysis of Research on 5-ALA Delivery and Theranostic Applications Based on a Scientometrics Study

Zhou

Luo

et al. 2022

Pharmaceutics

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5-aminolevulinic acid (5-ALA) has been extensively studied for its sustainability and broad-spectrum applications in medical research and theranostics, as well as other areas. It’s a precursor of protoporphyrin IX (PpIX), a sustainable endogenous and naturally-existing photosensitizer. However, to the best of our knowledge, a scientometrics study based on the scientific knowledge assay of the overall situation on 5-ALA research has not been reported so far, which would be of major importance to the relevant researchers. In this study, we collected all the research articles published in the last two decades from the Web of Science Core Collection database and employed bibliometric methods to comprehensively analyze the dataset from different perspectives using CiteSpace. A total of 1595 articles were identified. The analysis results showed that China published the largest number of articles, and SBI Pharmaceuticals Co., Ltd. was the most productive institution that sponsored several of the most productive authors. The cluster analysis and burst detections indicated that the improvement of photodynamic efficacy theranostics is the up-to-date key direction in 5-ALA research. Furthermore, we emphatically studied nanotechnology involvement in 5-ALA delivery and theranostics research. We envision that our results will be beneficial for researchers to have a panorama of and deep insights into this area, thus inspiring further exploitations, especially of the nanomaterial-based systems for 5-ALA delivery and theranostic applications.

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Section: Resultsmentioning

confidence: 99%

Evolutionary Trend Analysis of Research on 5-ALA Delivery and Theranostic Applications Based on a Scientometrics Study

Zhou

Luo

et al. 2022

Pharmaceutics

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“…28 In addition, 5-ALA-PDT markedly suppresses cell migration and invasion in A431 cells by enhancing apoptosis in cutaneous squamous cell carcinoma. 29 It has also been reported that Ph1-PDT activates the apoptotic-related proteins caspase-3 and caspase-8, inducing cell apoptosis. 30 Interestingly, our findings showed that Ph1-PDT reduces keloid fibroblast migration and invasion, and promotes apoptosis.…”

Section: Discussionmentioning

confidence: 98%

Phenalen-1-one-mediated photodynamic therapy inhibits keloid graft progression by reducing vessel formation and promoting fibroblast apoptosis

Zheng¹,

Wu²,

Liu³

et al. 2021

Adv Clin Exp Med

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“…This strategy has enabled higher death rates of cancer cells compared to free PS molecules. For some water-soluble second-generation PSssuch as methylene blue (MB) 70 and 5-aminolevulinic acid (5-ALA), 71 they fortunately bypass the problem associated with solubility of first-generation PSs. However, the hydrophilic nature limits the ability to cross lipophilic cell membranes, consequently decreasing the intracellular accumulation of the water-soluble PSs and PDT efficacy.…”

Section: Aunps In Cancer Therapymentioning

confidence: 99%

Multifunctional Gold Nanoparticles in Cancer Diagnosis and Treatment

Yang¹,

Zheng²,

Chen³

et al. 2022

IJN

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Cancer is the second leading cause of death in the world, behind only cardiovascular diseases, and is one of the most serious diseases threatening human health nowadays. Cancer patients’ lives are being extended by the use of contemporary medical technologies, such as surgery, radiotherapy, and chemotherapy. However, these treatments are not always effective in extending cancer patients’ lives. Simultaneously, these approaches are often accompanied with a series of negative consequences, such as the occurrence of adverse effects and an increased risk of relapse. As a result, the development of a novel cancer-eradication strategy is still required. The emergence of nanomedicine as a promising technology brings a new avenue for the circumvention of limitations of conventional cancer therapies. Gold nanoparticles (AuNPs), in particular, have garnered extensive attention due to their many specific advantages, including customizable size and shape, multiple and useful physicochemical properties, and ease of functionalization. Based on these characteristics, many therapeutic and diagnostic applications of AuNPs have been exploited, particularly for malignant tumors, such as drug and nucleic acid delivery, photodynamic therapy, photothermal therapy, and X-ray-based computed tomography imaging. To leverage the potential of AuNPs, these applications demand a comprehensive and in-depth overview. As a result, we discussed current achievements in AuNPs in anticancer applications in a more methodical manner in this review. Also addressed in depth are the present status of clinical trials, as well as the difficulties that may be encountered when translating some basic findings into the clinic, in order to serve as a reference for future studies.

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Enhanced anti-tumor efficacy of 5-aminolevulinic acid-gold nanoparticles-mediated photodynamic therapy in cutaneous squamous cell carcinoma cells

Cited by 29 publications

References 38 publications

Evolutionary Trend Analysis of Research on 5-ALA Delivery and Theranostic Applications Based on a Scientometrics Study

Evolutionary Trend Analysis of Research on 5-ALA Delivery and Theranostic Applications Based on a Scientometrics Study

Phenalen-1-one-mediated photodynamic therapy inhibits keloid graft progression by reducing vessel formation and promoting fibroblast apoptosis

Multifunctional Gold Nanoparticles in Cancer Diagnosis and Treatment

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