MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3

Wang, Jinghao; Chen, Xu; Huang, Wei

doi:10.1590/1414-431x202010550

Cited by 21 publications

(14 citation statements)

References 27 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The downregulation of hsa-miR-127-3p could be the leading factor in the overexpression of type I interferon (IFN) ( Wu et al, 2021 ). Besides, miR-132-3p and miR-369 suppressed the level of apoptosis, and miR-132-3p reduced the response of type I IFN to pave the way for influenza virus replication ( Zhang F. et al, 2019 ; Qu et al, 2021 ; Wang J. et al, 2021 ). Moreover, miR-451-3p could mitigate apoptosis and autophagy ( Tsai et al, 2018 ; Lv et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Profile of MA-104 Cell Line Associated With the Pathogenesis of Bovine Rotavirus Strain Circulated in Chinese Calves

Elkady

Chen

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Bovine rotavirus (BRV) causes massive economic losses in the livestock industry worldwide. Elucidating the pathogenesis of BRV would help in the development of more effective measures to control BRV infection. The MA-104 cell line is sensitive to BRV and is thereby a convenient tool for determining BRV–host interactions. Thus far, the role of the microRNAs (miRNAs) of MA-104 cells during BRV infection is still ambiguous. We performed Illumina RNA sequencing analysis of the miRNA libraries of BRV-infected and mock-infected MA-104 cells at different time points: at 0 h post-infection (hpi) (just after 90 min of adsorption) and at 6, 12, 24, 36, and 48 hpi. The total clean reads obtained from BRV-infected and uninfected cells were 74,701,041 and 74,184,124, respectively. Based on these, 579 were categorized as known miRNAs and 144 as novel miRNAs. One hundred and sixty differentially expressed (DE) miRNAs in BRV-infected cells in comparison with uninfected MA-104 cells were successfully investigated, 95 of which were upregulated and 65 were downregulated. The target messenger RNAs (mRNAs) of the DE miRNAs were examined by bioinformatics analysis. Functional annotation of the target genes with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) suggested that these genes mainly contributed to biological pathways, endocytosis, apoptotic process, trans-Golgi membrane, and lysosome. Pathways such as the mammalian target of rapamycin (mTOR) (mml-miR-486-3p and mml-miR-197-3p), nuclear factor kappa B (NF-κB) (mml-miR-204-3p and novel_366), Rap1 (mml-miR-127-3p), cAMP (mml-miR-106b-3p), mitogen-activated protein kinase (MAPK) (mml-miR-342-5p), T-cell receptor signaling (mml-miR-369-5p), RIG-I-like receptor signaling (mml-miR-504-5p), AMP-activated protein kinase (AMPK) (mml-miR-365-1-5p), and phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) signaling (mml-miR-299-3p) were enriched. Moreover, real-time quantitative PCR (qPCR) verified the expression profiles of 23 selected DE miRNAs, which were consistent with the results of deep sequencing, and the 28 corresponding target mRNAs were mainly of regulatory pathways of the cellular machinery and immune importance, according to the bioinformatics analysis. Our study is the first to report a novel approach that uncovers the impact of BRV infection on the miRNA expressions of MA-104 cells, and it offers clues for identifying potential candidates for antiviral or vaccine strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

MicroRNA Profile of MA-104 Cell Line Associated With the Pathogenesis of Bovine Rotavirus Strain Circulated in Chinese Calves

Elkady

Chen

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…In line with its anti-inflammatory role, miR-369 over-expression is able to suppress cardiomyocyte apoptosis and inflammation pathways triggered by hypoxia (77). Furthermore, plasma of patients with HF, following AMI, exhibited higher miR-369 expression levels, compared to subjects affected by MI without HF (78).…”

Section: Mir-369mentioning

confidence: 92%

“…In line with its anti-inflammatory role, miR-369 overexpression is able to suppress cardiomyocyte apoptosis and inflammation pathways triggered by hypoxia ( 77 ).…”

Section: Introductionmentioning

confidence: 99%

microRNAs involved in psoriasis and cardiovascular diseases

et al. 2021

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory disease involving skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different comorbidities such as diabetes, metabolic syndrome, gastrointestinal or kidney diseases, cardiovascular diseases (CVD), and cerebrovascular diseases (CeVD). Indeed, life expectancy in severe psoriasis is reduced by up to 5 years due to CVD and CeVD. Moreover, patients with severe psoriasis have a higher prevalence of traditional cardiovascular (CV) risk factors, including dyslipidaemia, diabetes, smoking, and hypertension. Further, systemic inflammation is associated with oxidative stress increase and induces endothelial damage and atherosclerosis progression. Different microRNAs have been already described in psoriasis, both in the skin tissues and in the blood flow, to play a role in the progression of disease. In this review we will summarize and discuss the most important miRNAs that play a role in psoriasis and have been also linked to CVD.

show abstract

“…Overexpression of miR-26a-5p significantly inhibits cardiomyocyte apoptosis and improves cardiac function by repressing Phosphatase and tensin homolog (PTEN), thereby activating the PI3K/AKT signaling pathway; thus, miR-26a-5p protects cardiac function via regulating PTEN/PI3K/AKT upon ischemia/reperfusion injury [68]. Wang et al demonstrated that miR-369 overexpression reduces cell apoptosis, inflammation, and is accompanied by decreased caspase-3 activity, secretion of interleukin (IL)-6, IL-1β, and TNF-α by suppressing Transient Receptor Potential Cation Channel Subfamily V Member 3 (TRPV3) [69]. When overexpressed in rat cardiomyocytes under hypoxiareoxygenation conditions, miR-129-5p decreases cell death by targeting HMGB1 [70].…”

Section: 整体完成率没有问题，但是做稿子速度慢了一点，有时候周末要加班。正如范丽影自己说的，自己是个问题宝宝，爱问问题的宝...mentioning

confidence: 99%

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Kansakar

Varzideh

Mone

et al. 2022

Cells

View full text Add to dashboard Cite

microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

show abstract

MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3

Cited by 21 publications

References 27 publications

MicroRNA Profile of MA-104 Cell Line Associated With the Pathogenesis of Bovine Rotavirus Strain Circulated in Chinese Calves

MicroRNA Profile of MA-104 Cell Line Associated With the Pathogenesis of Bovine Rotavirus Strain Circulated in Chinese Calves

microRNAs involved in psoriasis and cardiovascular diseases

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Contact Info

Product

Resources

About