Abstract:Contradictory findings suggest that the behavioral and abuse-related effects of ethanol are mediated by its action at a1 subunitcontaining GABA A (a1GABA A) receptors. In the present study, we investigated the effects of a sub-chronic post-ethanol administration treatment with zolpidem, an a1-preferring positive allosteric modulator at GABA A receptors, on the subsequent expression of ethanol-induced behavioral sensitization in mice. Animals received ethanol (1.8 g/kg, ip) or saline treatments every other day … Show more
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