Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Benseñor, Isabela M.

doi:10.1590/1414-431x20198417

Cited by 5 publications

(3 citation statements)

References 82 publications

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“…35,36 In view of patients with T2DM with no evidence of thyroid disease, Giandalia et al 37 demonstrated that higher values of TSH within normal range were more frequent in women and younger patients and were associated with visceral obesity and higher triglyceride concentrations-two well-known CVD risk factors, although in this study, no CV outcomes were evaluated. Considering CIMT and thyroid function, in the Elsa Brazil study, 38 after a multivariate adjustment for sociodemographic and CVR factors, subclinical hypothyroidism was associated with higher CIMT values using euthyroid subjects as the reference. However, in other studies, the authors observed that thyroid hormone was not predictive of carotid atherosclerosis when adjusted for confounders, 39 and no significant relationship between CIMT and serum TSH levels was observed in normal, nonthyroxine-taking subjects.…”

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

“…The patients were recruited into a single tertiary care center with only internal validity. Only one TSH/Free T4 sample was collected for the determination of thyroid function, as has been done in other studies evaluating thyroid function 38 and the determination of antiperoxidase antibodies was not performed. Another potential limitation was the reliance on self-reported FH of premature CAD and of thyroid disease, although most studies addressed this in the same way.…”

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

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<p>Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes</p>

Palma¹,

Lopes²,

Silva³

et al. 2020

DMSO

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Aim: There is a wide variety of cardiovascular outcomes in patients with type 2 diabetes (T2DM), even in asymptomatic individuals. Carotid intima-media thickness (CIMT) is a marker of subclinical atherosclerosis and can be considered as a predictor of cardiovascular risk (CVR). The aim of this study was to evaluate the relationship between CIMT-determined vascular age (VA), CVR scores, and thyroid function in asymptomatic patients with T2DM. Patients and Methods: Clinical laboratory and CIMT parameters were measured in 154 asymptomatic patients with T2DM. The Framingham risk score (FRS) was performed with chronological age (CA) and with VA. A multinomial logistic regression model was used to analyze variables related to CVR reclassification. Results: The use of CIMT-determined VA led to the reclassification of 54 (35.52%) out of 152 asymptomatic T2DM patients, being 20 (37.03%) to a lower categorical risk and 34 (62.96%) to a higher categorical risk according to FRS. The variables that were associated to reclassification to a higher categorical risk were positive family history (FH) of premature coronary artery disease (p=0.046), FH of thyroid disease (p=0.010), use of statins (p=0.027), and free T4 levels (p=0.009). Conclusion: VA determined from CIMT allowed the reclassification of the CVR in asymptomatic T2DM patients. FH of premature CAD, FH of known thyroid disease, use of statins, and free T4 levels were associated to a reclassification into a higher risk category. The use of doppler to perform CIMT measure is currently more accessible, especially in a low-middle income country like Brazil. However, further prospective studies must be performed to establish the predictive values of CIMT on atherosclerosis and how thyroid function acts like cardiovascular risk marker on CVR scores.

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Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

<p>Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes</p>

Palma¹,

Lopes²,

Silva³

et al. 2020

DMSO

View full text Add to dashboard Cite

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“…Thyroid disease is common not only in Pakistan but also all over the world. 1 Factors associated with increased incidence depend upon iodine status, but also on advancing age, gender, ethnical group and geographical area. 2,3 Its rising incidence is also associated with highest mortality rate annually as compared to all other endocrine cancers.…”

Section: Introductionmentioning

confidence: 99%

Incident of Thyroid Carcinomas and Other Pathologies with Age Correlation in Patients Presented with Palpable Thyroid Masses Undergoing Thyroidectomies

Niaz

Aneeqa

Kazi

et al. 2021

APMC

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Background: Thyroid cancer is the leading cause of death both in developing and developed countries. Patients present with enlarged thyroid. Radiology shows hot and cold nodules. Thyroidectomy or lobectomy is done to rule out malignancy. Objective: To determine the incidence of thyroid carcinomas and other pathologies in thyroidectomy specimen of different age group patients presenting with clinically enlarged thyroid. Study Design: Cross-sectional study. Settings: Department of Histopathology, Foundation University Medical College (FUMC), Islamabad and Department of surgery, Fauji Foundation Hospital (FFH), Rawalpindi Pakistan. Duration: from Jan 2012 to March 2019. Methodology: All the thyroidectomies specimens send from Surgery department of FFH to Histopathology Department of FUMC during study period and fulfilling the pre-set criteria were included in the study. All the data and results were analyzed using SPSS version 17.0. Results: Out of 500 total patients, 89% (n=445) were diagnosed as having multinodular goiter, 2.6% (n=13) thyroiditis, 2.2% (n=11) follicular adenoma, 0.8% (n=4) Hurthle cell adenoma, 0.2%(n=1) hyalinizing trabacular adenoma and thyroid carcinomas. The carcinomas comprised 2.6%(n=13) papillary carcinoma, 0.8%(n=4) poorly differentiated carcinoma,0.8%(n=4) anaplastic carcinoma,0.6%(n=3) medullary carcinoma and 0.4%(n=2) follicular carcinoma. In 445 patients of multinodular goiter 158 patients were in the age range of 41-50 years, in 13 cases of thyroiditis 7 were in the age range of 31-40 years, in 11 cases of follicular adenoma 4 patients were in the age range of 31-40 years, in 4 cases of hurthle cell adenoma 3 patients were in the age range of 41-50 years, in 13 cases of papillary thyroid carcinoma 5 patients were in the age range of 31-40 years, in 4 cases of poorly differentiated carcinoma 2 patients were in the age range of 41-50 years and in 4 cases of anaplastic carcinoma 2 patients were in the age range of 61-70 years. Conclusion: The study concluded that thyroid carcinomas collectively constituted 5.20% of the study cases. Papillary carcinoma was the most frequent malignant neoplasm constituting 2.6 % and occurring mostly in the age range of 31-40 years, while anaplastic carcinoma comprised of 0.8% of malignant lesions occurring in the age range of 61-70 years. The most frequent cause of thyroid enlargement was multinodular goiter (89%) with majority of the patients in the age range of 41-50 years.

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Thyrotoxicosis in Africa: a systematic review and meta-analysis of the clinical presentation

2022

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Background Thyrotoxicosis is a common endocrine disorder. The clinical presentation is variable, and it is often misdiagnosed or diagnosed late in Africa. This study was aimed at collating and analyzing the clinical characteristics of the disease across the continent so as to enhance correct and timely diagnosis. Methods The study is a systematic review with a meta-analysis. Studies, done in Africa, which documented the clinical features of thyrotoxicosis were selected. African Journal Online (AJOL), PubMed, SCOPUS and Google Scholar, Research Square, SciELO, and medRxiv were systematically searched using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study quality was assessed using the Newcastle-Ottawa scale. Heterogeneity was determined using I2 statistic and Cochran’s Q test. LFK index and the symmetry of the Doi plot were used to assess publication bias. Results The eligible studies were 59 and the total sample size was 9592. The most common symptoms of thyrotoxicosis on the continent included palpitations (69%), weight loss (65%), heat intolerance (64%), tiredness (49%), increased appetite (49%), hyperhidrosis (48%), and insomnia (47%). The most common signs were thyromegaly (88%), tachycardia (67%), sweaty palms (54%), hand tremor (49%), and exophthalmos (49%). Atrial fibrillation, heart failure, and thyrotoxic heart disease were found in 9, 12, and 22% respectively. Other findings were hypertension (25%) and diabetes (9%). Conclusion Clinical presentation of thyrotoxicosis varies, and understanding these peculiarities would mitigate misdiagnosis and delayed diagnosis in Africa.

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Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Cited by 5 publications

References 82 publications

<p>Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes</p>

<p>Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes</p>

Incident of Thyroid Carcinomas and Other Pathologies with Age Correlation in Patients Presented with Palpable Thyroid Masses Undergoing Thyroidectomies

Thyrotoxicosis in Africa: a systematic review and meta-analysis of the clinical presentation

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