Synthesis and anti-myocarditis activity in a multifunctional lanthanide microporous metal-organic framework with 1D helical chain building units

Abstract

A new microporous lanthanide metal-organic framework, {[Yb(BTB)(H2O) (DEF)2}n (1, DEF=N,N-Diethylformamide), with 1D nano-sized channels has been constructed by bridging helical chain secondary building units with 1,3,5-benzenetrisbenzoic acid (H3BTB) ligand. Structural characterization suggests that this complex crystallizes in the hexagonal space group P6122 and possesses 1D triangular channels with coordinated water molecules pointing to the channel center. In addition, anti-myocarditis properties of compound 1 were evaluated in vivo. The results showed that compound 1 can improve hemodynamic parameters of, and it may be a good therapeutic option for heart failure in the future.

Microporous metal–organic frameworks: Synthesis and applications

“…Microporous MOFs can also be synthesized by bridging helical chain secondary building units from suitable ligands. Hong et al [23] reported the synthesis procedure of microporous lanthanide MOFs by linking the helical chain secondary building units built up from the H 3 BTB ligand. The formula of this MOF is {[Yb (BTB)(H 2 O)(DEF) 2 }, in which DEF is N,N-diethylformamide.…”

“…The obtained result was a structure with pentagonal bipyramid geometry, and Yb-O bond distances were measured to be approximately 2 Å. Moreover, the solvothermal reaction was the synthesis procedure of these lanthanide MOFs [23]. Lanthanide metals have attracted the attention of researchers as metal centers due to their coordination properties and excellent physical and chemical features.…”

“…The pore size in MOFs can be tuned by selecting appropriate building block molecules, adding different functional groups to the organic ligands or metal ions, or through pre-synthetic and post-synthetic modifications [21,22]. Usually, the organic linker has a vital role in forming porous MOFs and tailoring the pore shapes and sizes [23]. In this regard, pore sizes of MOFs could be adjusted by utilizing various organic linkers with different structures and geometries to coordinate with metal nodes [12][13][14].…”

“…Furthermore, different strategies have been developed for controllable synthesis of microporous MOFs and their frameworks, including the modulator-induced defect-formation approach [31], using structure-directing agents, pillared-layer assembly [29], acoustic cavitation within collapsing bubbles [30], bridging helical chain secondary building units [32], coordination capabilities of P@O moieties in the structure of a ligand [23], and octahedral cage-like building units strategy [33].…”