Two novel Mg(II)-based and Zn(II)-based complexes: inhibiting growth of human liver cancer cells

Abstract

Two new Mg(II)-based and Zn(II)-based coordination polymers, {[Mg3(BTB)(DMA)4](DMA)2}n (1, H3BTB=1,3,5-benzenetrisbenzoic acid, DMA=N,N-dimethylacetamide) and {(H2NMe2)2[Zn3(BTB)2(OH)(Im)](DMF)9(MeOH)7}n (2, Im=imidazole, DMF=N,N-dimethylformamide), have been successfully synthesized and structurally characterized under solvothermal conditions. 1 contains a linear [Mg3(COO)6] cluster that connected by the fully deprotonated BTB3- ligands to give a kgd-type 2D bilayer structure; 2 represents a microporous 3D pillar-layered system based on the binuclear Zn units and pillared Im ligands, which shows a (3,5)-connected hms topological net. In addition, in vitro anticancer activities of compounds 1 and 2 on 4 human liver cancer cells (HB611, HHCC, BEL-7405 and SMMC-7721) were determined.

Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes

“…The imidazole ring is found in very significant endogenous biomolecules, such as biotin, the autacoid histamine and the essential amino acid histidine [5]. Additionally, the imidazole derivatives are highly important in medicinal chemistry research; a lot of imidazole-containing compounds show biological activities such as antifungal, antibacterial, anti-inflammatory and anthelmintic [6], antitubercular [7], antiblood pressures, antiallergic, antiasthma [8] and anticancer [9]. Antipyrine is well known for its pharmaceutical as well as medical applications including antibacterial, antifungal [10], antituberculosis, anticancer [11], antitumor and antioxidant [12].…”

Preparation and Biological Activities of Some Heterocyclic Compounds Derivatives from 2-Aminothiazoles

“…The synthesis of 2-aminothiazoles derivatives has several problems including low yield, harsh reactions, difficult isolation procedures, use of expensive catalysts [4][5][6] and so on. Thiazole derivatives are significantly important heterocyclic compounds which exhibit a wide range of biological activities such as fungicidal [7], bactericidal [8], cardiovascular [9], antitumor [10], anti-allergic [11], central nervous system stimulate [12,13] and antipyretic [14]. Due to the broad range of their applications, 2-aminothiazoles have been used in the synthesis of polymers [15,16].…”