Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma

Jiao, Yang; Yan, Wei; Du, Dong

doi:10.1590/1414-431x20176867

Cited by 32 publications

(21 citation statements)

References 23 publications

(29 reference statements)

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“…Our findings are in agreement with a very recent study in which PD inhibited the invasion and migration of human liver cancer cells. 20 The degradation of basement membranes and stromal extracellular matrix is an essential step that leads to invasion and metastasis. MMPs are a family of human zinc-dependent endopeptidases that are responsible for degradation of the extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway

Jin¹,

Xin²,

Zhou³

et al. 2018

OTT

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PurposePolydatin, a stilbenoid glucoside of a resveratrol derivative, has many biological functions, including antitumor effects. However, the antitumor effects of polydatin in renal cell carcinoma (RCC) have not been investigated.Materials and methodsIn the current study, MTT assays, transwell invasion assays and wound healing assays were performed to examine cell proliferation, invasion and migration. An apoptosis nucleosome ELISA was used to measure apoptosis. Caspase activity assays were applied to measure the activities of caspase-3/9. A Western blot assay was used to measure the change in protein levels.ResultsOur data demonstrated that polydatin inhibited the proliferation of RCC cells but not normal renal epithelial cells in a time- and dose-dependent manner. Polydatin also triggered apoptosis in a caspase-dependent manner. Moreover, polydatin treatment also led to the downregulation of Bcl-2 and Mcl-1 and to activation of Bax. Ectopic expression of Bcl-2 and Mcl-1 or silencing of Bax could repress the apoptosis that was induced by polydatin. Moreover, incubation with polydatin also suppressed the PI3K/Akt signaling pathway in RCC cells.ConclusionTaken together, our data indicated that polydatin may be applied as a potent agent against RCC.

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Section: Discussionmentioning

confidence: 99%

Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway

Jin¹,

Xin²,

Zhou³

et al. 2018

OTT

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“…The root of Polygonum cuspidatum is usually formulated with several other ingredients and is most commonly prescribed for treating coughs, hepatitis, jaundice, amenorrhea, leucorrhea, arthralgia, burns, and snake bite [255]. A diversity of compounds have been isolated from Polygonum cuspidatum , dominated by resveratrol, polydatin, and anthraquinones and are presumed to be responsible for Polygonum cuspidatum 's anti-inflammatory, estrogenic, antitumour, antiaging, neuroprotective, and cardioprotective activities [256–258]. In one recent in vivo study examining wound healing in rats, extracts of Polygonum cuspidatum were found to increase TGF- β 1 expression and to significantly improve wound healing in terms of reepithelization, granulation tissue formation, collagen synthesis, and angiogenesis [259].…”

Section: Traditional Use Of Medical Plants In Wound Healingmentioning

confidence: 99%

Wound Healing and the Use of Medicinal Plants

Shedoeva

Leavesley

Upton

et al. 2019

Evidence-Based Complementary and Alternative Medicine

216

132

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Cutaneous wound healing is the process by which skin repairs itself. It is generally accepted that cutaneous wound healing can be divided into 4 phases: haemostasis, inflammation, proliferation, and remodelling. In humans, keratinocytes re-form a functional epidermis (reepithelialization) as rapidly as possible, closing the wound and reestablishing tissue homeostasis. Dermal fibroblasts migrate into the wound bed and proliferate, creating “granulation tissue” rich in extracellular matrix proteins and supporting the growth of new blood vessels. Ultimately, this is remodelled over an extended period, returning the injured tissue to a state similar to that before injury. Dysregulation in any phase of the wound healing cascade delays healing and may result in various skin pathologies, including nonhealing, or chronic ulceration. Indigenous and traditional medicines make extensive use of natural products and derivatives of natural products and provide more than half of all medicines consumed today throughout the world. Recognising the important role traditional medicine continues to play, we have undertaken an extensive survey of literature reporting the use of medical plants and plant-based products for cutaneous wounds. We describe the active ingredients, bioactivities, clinical uses, formulations, methods of preparation, and clinical value of 36 medical plant species. Several species stand out, including Centella asiatica, Curcuma longa, and Paeonia suffruticosa, which are popular wound healing products used by several cultures and ethnic groups. The popularity and evidence of continued use clearly indicates that there are still lessons to be learned from traditional practices. Hidden in the myriad of natural products and derivatives from natural products are undescribed reagents, unexplored combinations, and adjunct compounds that could have a place in the contemporary therapeutic inventory.

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“…Additionally, PC exerts antibacterial, antiviral, and liver protection effect that can promote liver cell regeneration and recovery. Thereby, the beneficial effects of PC make it have therapeutic effect on acute hepatic ischemic injury, as evidenced by abrogated acute liver injury caused by carbon tetrachloride (CCl 4 ) [17,18]. In our study, we found that DSLHG could alleviate liver fibrosis induced by CCl 4 in rats and raised one new hopeful drug for the treatment of hepatic fibrosis.…”

Section: Introductionmentioning

confidence: 66%

Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis

Tao

Tian

Chen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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This study aims to predict the active ingredients, potential targets, signaling pathways and investigate the “ingredient-target-pathway” mechanisms involved in the pharmacological action of Danshiliuhao Granule (DSLHG) on liver fibrosis. Pharmacodynamics studies on rats with liver fibrosis showed that DSLHG generated an obvious anti-liver fibrosis action. On this basis, we explored the possible mechanisms underlying its antifibrosis effect using network pharmacology approach. Information about compounds of herbs in DSLHG was collected from TCMSP public database and literature. Furthermore, the oral bioavailability (OB) and drug-likeness (DL) were screened according to ADME features. Compounds with OB≥30% and DL≥0.18 were selected as active ingredients. Then, the potential targets of the active compounds were predicted by pharmacophore mapping approach and mapped with the target genes of the specific disease. The compound-target network and Protein-Protein Interaction (PPI) network were built by Cytoscape software. The core targets were selected by degree values. Furthermore, GO biological process analysis and KEGG pathway enrichment analysis were carried out to investigate the possible mechanisms involved in the anti-hepatic fibrosis effect of DSLHG. The predicted results showed that there were 108 main active components in the DSLHG formula. Moreover, there were 192 potential targets regulated by DSLHG, of which 86 were related to liver fibrosis, including AKT1, EGFR, and IGF1R. Mechanistically, the anti-liver fibrosis effect of DSLHG was exerted by interfering with 47 signaling pathways, such as PI3K-Akt, FoxO signaling pathway, and Ras signaling pathway. Network analysis showed that DSLHG could generate the antifibrosis action by affecting multiple targets and multiple pathways, which reflects the multicomponent, multitarget, and multichannel characteristics of traditional Chinese medicine and provides novel basis to clarify the mechanisms of anti-liver fibrosis of DSLHG.

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Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma

Cited by 32 publications

References 23 publications

Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway

Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway

Wound Healing and the Use of Medicinal Plants

Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis

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