Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility

Wu, Bangwei; Zhu, Jun; H, Shi; Wen, Zhichao

doi:10.1590/1414-431x20176306

Cited by 3 publications

(2 citation statements)

References 37 publications

(17 reference statements)

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“…By contrast, Morange et al demonstrated that this SNP is not a significant predictor of the CV risk in healthy individuals [46]. These data are in line with the results of two meta-analyses based on 12 and 20 case-control studies, in which nonassociation of this SNP with CV diseases was proven [23,47]. And also, in the present study, no correlation between this genetic variant and the occurrence of preexisting CV diseases could be shown.…”

Section: Snps and The Cardiovascular Prognosis In The 3-yearsupporting

confidence: 91%

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Schulz

Zielske

Schneider

et al. 2021

Mediators of Inflammation

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Background. The biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system—(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor-κΒ (NF-κB)—was investigated. Materials and Methods. In this study (ClinicalTrials.gov identifier: NCT01045070), 1002 cardiovascular (CV) patients were included. In a 3-year follow-up period, new vascular events were assessed. SNPs in CD14 (rs2569190), NF-κΒ (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) were genotyped. The impact of these genetic variants on severe periodontitis as well as on CV outcome was assessed. Results. All investigated genetic variants were not associated with preexisting CV events or severe periodontitis in CV patients. In Kaplan-Meier survival analyses, the CT genotype of CD14 single-nucleotide polymorphism (SNP) rs2569190 was shown to be an independent predictor for combined CV endpoint (log rank: p = 0.035 ; cox regression; hazard ratio: 1.572; p = 0.044 ) as well as cardiovascular death (log rank: p = 0.019 ; cox regression; hazard ratio: 1.585; p = 0.040 ) after three years of follow-up. Conclusions. SNPs in CD14, NF-κΒ, TLR2, and TLR4 are no risk modulators for preexisting CV events or severe periodontitis in CV patients. The CT genotype of CD14 SNP rs2569190 provides prognostic value for further CV events within 3 years of follow-up.

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Section: Snps and The Cardiovascular Prognosis In The 3-yearsupporting

confidence: 91%

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Schulz

Zielske

Schneider

et al. 2021

Mediators of Inflammation

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“…The results for rs4986790 were in line with those of 2 prior meta-analyses. 35,36 However, we could not exclude the possibility that rs4986790 along with other factors may have a synergistic effect on CAD risk. Boekholdt et al found that among patients with coronary atherosclerosis, cardiovascular events, including myocardial infarction, were significantly decreased when statins were administered to carriers of the rs4986790 G allele.…”

Section: Discussionmentioning

confidence: 99%

Association of coronary artery disease with toll-like receptor 4 genetic variants: A meta-analysis

Sheng

2019

Adv Clin Exp Med

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Association of coronary artery disease with tolllike receptor 4 genetic variants: A meta-analysis. AbstractBackground. Toll-like receptor 4 (TLR4) plays an important role in the formation of coronary atherosclerotic plaque and the pathogenesis of coronary artery disease (CAD).Objectives. The aim of the study was to conduct a meta-analysis assessing the relationship between 2 common genetic variants in the TLR4 gene (rs4986790 and rs4986791) and susceptibility to CAD. Material and methods.A systematic search of Web of Science, Embase, Scopus, PubMed, and Wanfang Med Online was undertaken. Case-control studies assessing the association of rs4986790 and rs4986791 with CAD risk were included. The odds ratio (OR) and 95% confidence interval (CI) were used as the metric of choice for the evaluation of risk.Results. The literature search generated 427 studies, of which 14 met the inclusion criteria, for a total of 13,927 participants. Our meta-analysis revealed a significant association between rs4986791 and CAD risk in Asians using the dominant model (CT + TT vs CC: OR = 0.35, 95% CI = 0.21-0.56, p < 0.001), heterozygote contrast (CT vs CC: OR = 0.32, 95% CI = 0. 19-0.57, p < 0.001) and allele contrast (T vs C: OR = 0.38, 95% CI = 0.25-0.58, p < 0.001). No significant association between rs4986791 and CAD was observed among Caucasians. For rs4986790, the results provided no evidence of an association with CAD risk.Conclusions. Our analysis suggests that rs4986791 is negatively associated with CAD risk in Asians but not in Caucasians. No association between rs4986790 and CAD risk was found.

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Local inflammatory responses take their toll on the heart

Jager

Hoefer

2019

International Journal of Cardiology

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Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility

Cited by 3 publications

References 37 publications

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Association of coronary artery disease with toll-like receptor 4 genetic variants: A meta-analysis

Local inflammatory responses take their toll on the heart

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