Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population

Abstract

Many studies have evaluated the correlation between peptidylarginine deiminase 4 (PADI4) -92C/G polymorphism and rheumatoid arthritis (RA), but the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between PADI4 -92C/G polymorphism and RA. Eligible studies published before May 2016 were identified in PubMed and Chinese databases. The strengths of these associations were assessed by pooled odds ratios (OR) and 95% confidence interval (CI). Eight studies documenting a total of 1351 RA cases and 1585 controls were included in this meta-analysis. In the overall analysis, a significant association between the PADI4 -92C/G polymorphism and RA was found in the Chinese population (G vs C: OR=1.32, 95%CI=1.02–1.71; GG+CG vs CC: OR=1.75, 95%CI=1.20–2.53). The subgroup analyses stratified by geographic area(s) and source of controls revealed significant results in South China, in hospital-based studies and population-based studies. In summary, this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the RA incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.

Efeito Da Terapia Periodontal Não Cirúrgica Na Redução Da Severidade Da Artrite Reumatoide

“…Apesar desse conhecimento, vale salientar que contrariamente alguns pacientes acometidos com a doença não apresentam estes genes, bem como a presença destes genes também não significa que o portador irá sempre demonstrar sinais clínicos 10 . Além dos fatores genéticos, inúmeros vírus e bactérias foram investigados como também sendo possíveis causadores da doença 15,16 . Neste contexto, vale ainda salientar que doenças inflamatórias crônicas, tal como a PC, podem interagir sinergicamente com a AR 17 .…”