2017
DOI: 10.1590/1414-431x20165637
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Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia

Abstract: Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effector T cell activation is an important mechanism in the pathogenesis of ITP. Regulatory T cells (Treg) have a strong immunosuppressive function for T cell activation and their importance in the pathophysiology and clinical treatment of ITP has been confirmed. Myeloid-derived suppressor cells (MDSCs) are other immunosuppressive cells, which can also suppress T cell activation by secreting arginase, iNOS and ROS, … Show more

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Cited by 10 publications
(8 citation statements)
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“…MDSCs are uniformly characterized by the co-expression of myeloid-cell lineage differentiation antigen GR1 and CD11b [ 22 , 23 ] in mice, but cell surface markers defining human MDSCs have not yet to be confirmed [ 24 26 ]. CD11b + CD33 + HLA-DR − cells sharing multiple MDSCs features were recently identified in ITP patients [ 6 , 7 ]. M2 macrophages are often identified based on the expression patterns of a set of diverse markers.…”
Section: Discussionmentioning
confidence: 99%
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“…MDSCs are uniformly characterized by the co-expression of myeloid-cell lineage differentiation antigen GR1 and CD11b [ 22 , 23 ] in mice, but cell surface markers defining human MDSCs have not yet to be confirmed [ 24 26 ]. CD11b + CD33 + HLA-DR − cells sharing multiple MDSCs features were recently identified in ITP patients [ 6 , 7 ]. M2 macrophages are often identified based on the expression patterns of a set of diverse markers.…”
Section: Discussionmentioning
confidence: 99%
“…MDSCs could expand under pathological conditions including multiple sclerosis [ 28 ], rheumatoid arthritis [ 29 , 30 ] and autoimmune hepatitis [ 31 ]. Recently, studies have shown that circulating MDSCs were reduced in ITP patients [ 6 , 7 ]. In the present study, accumulation of MDSCs but not the M2-like macrophages was observed in ITP patients.…”
Section: Discussionmentioning
confidence: 99%
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“…Investigations regarding the mechanism of autoimmune diseases have focused mainly on the destruction of platelets, decrease in platelet production and T lymphocyte immune imbalance (3,14). Studies of the survival of megakaryocytes in ITP patients are rare and few studies have investigated the role of autophagy in ITP.…”
Section: Discussionmentioning
confidence: 99%