Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome

Castro, Érique; Mostarda, Cristiano Teixeira; Rodrigues, Bruno; Moraes‐Silva, Ivana C.; Feriani, Daniele Jardim; Angelis, Kátia De; Irigoyen, Maria Cláudia

doi:10.1590/1414-431x20144217

Cited by 8 publications

(4 citation statements)

References 39 publications

(53 reference statements)

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“…Finally, the analysis and comparison with animal studies could shed some light on the behavior of IOP with exercise. For instance, Castro et al [ 72 ] found positive results in the IOP of rats on a high-fructose diet with treadmill exercise at low intensity. These authors proposed as potential underlying mechanisms improved insulin sensitivity, reduced arterial pressure, and diminished peripheral sympathetic modulation [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Castro et al [ 72 ] found positive results in the IOP of rats on a high-fructose diet with treadmill exercise at low intensity. These authors proposed as potential underlying mechanisms improved insulin sensitivity, reduced arterial pressure, and diminished peripheral sympathetic modulation [ 72 ]. Additionally, one study reported that swimming can reverse the negative impact of aging on the optic nerve function of rats [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

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Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?

Gené-Morales

Sampedro

Martín-Portugués

et al. 2021

JCM

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To evaluate the effects of an acrobatic gymnastics (AG) training session on intraocular pressure (IOP), a familiarization session was employed to confirm the participant’s suitability for the study. Forty-nine gymnasts (63.27% females, 18–40 years old) voluntarily agreed to participate. As age, sex, baseline IOP, and central corneal thickness (CCT) were considered as potential predictors of the IOP variations, in the second session measurements of the above parameters were taken before and after 90 min of AG. A mixed-factorial analysis of variance evaluated differences. Linear regression was conducted to potentially predict the IOP variation with the exercise. After the scheduled exercise, highly significant (p < 0.001, effect size: 0.73) reductions in IOP, but no significant changes in CCT (p = 0.229), were observed. IOP was significantly modified in males, older than 25 years, and subjects with baseline IOP > 14 mmHg (p ≤ 0.001, effect sizes: 0.57–1.02). In contrast, the IOP of females, younger participants, and subjects with baseline IOP ≤ 14 mmHg was not significantly modified (p = 0.114). With the regression analyses, we concluded that both sex and baseline IOP levels were significant predictors of the IOP fluctuation with AG. These findings could be of interest for gymnasts, coaches, ophthalmologists, and/or optometrists in the prevention and control of risk factors associated with glaucoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?

Gené-Morales

Sampedro

Martín-Portugués

et al. 2021

JCM

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“…Previously, the beneficial effect of training has been studied in IOP, where despite being transiently reduced by dynamic exercise, for the great majority of patients, exercise is beneficial to the eyes by reducing the risk of central retinal vein occlusion and neovascular AMD and by improving the control of systemic hypertension and diabetes [50, 51]. Therefore, more research is needed to determine whether exercise also has an influence on other parts of the eye or may have other benefits, as it is well known that the physiological effects that occur in the long term in people who do physical activity are changeable.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness and Volume Modifications Induced by Aerobic Exercise in Healthy Young Adults

Insa-Sánchez¹,

Fuentes-Broto²,

Cobos³

et al. 2020

Ophthalmic Res

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Introduction: Our aim was to evaluate the changes in choroidal thickness (CT) and volume (CV) following aerobic physical exercise in healthy young adults. Methods: This study included 72 eyes from healthy volunteers between 22 and 37 years old. Using the International Physical Activity Questionnaire, total physical activity was computed. Measurements using an autorefractometer, ocular biometry, and spectral-domain optical coherence tomography using the Enhanced Depth Imaging protocol were taken. OCT was performed as a baseline measurement and after performing 10 min of dynamic physical exercise (3 and 10 min post-exercise). The choroidal layer was manually segmented, and the CT and CV in different areas from the Early Treatment Diabetic Retinopathy Study grid were obtained. Results: In healthy adults, at 3 min post-exercise, CT was higher in the subfoveal, the 3-mm nasal, and the 6-mm superior areas. Between 3 and 10 min post-exercise, the CT was reduced in all areas, and in some areas, the values were even smaller than the baseline measurements. The CV values showed changes after exercise similar to those of thickness. The total CV recovery after exercise was related to sex and physical activity level. Conclusion: Individuals with higher physical activity habits had greater CV at rest than those with lower physical activity levels. During exercise, healthy young people adjust CT and CV. At 3 min post-exercise, CT and CV increase. Women and individuals with greater physical activity levels reduce their total CV more than others during recovery.

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“…Rede Brasileira de Informações Biológicas -Rebibio www.rebibio.net CASTRO, 2015). Uma possível explicação para essa divergência são as diferentes metodologias utilizadas, limitando as conclusões aqui apresentadas.…”

Section: Tônus Simpático Vascularunclassified

Resposta cardiovascular ao estresse emocional agudo de ratos submetidos à suplementação alimentar rica em frutose

Alves¹,

Vasconcelos²,

Guimarães³

2016

Anais do Congrebio 2016

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RESUMOO estresse é um fator de risco para desenvolvimento de doenças cardiovasculares em seres humanos e diversos estudos têm mostrado que a obesidade induz a uma resposta cardíaca exacerbada a exposição ao estresse. Em adição, o consumo elevado de frutose na atual sociedade, tem se mostrado um fator predisponente ao surgimento da síndrome metabólica, que por sua vez, oferece prejuízos a saúde do coração. Neste contexto, o objetivo deste estudo foi avaliar a capacidade de resposta cardiovascular ao estresse agudo de contenção e outras alterações fisiológicas em uma dieta rica em frutose (CEUA-UFAL 19/ 2015). Para isso, ratos wistar machos (7 semanas de idade) foram submetidos a 10 semanas de dieta rica em frutose (FF) ou água potável (grupo controle -CTL). Foram avaliados: a pressão arterial média (PAM), a frequência cardíaca (FC), a sensibilidade do controle barorreflexo da frequência cardíaca (BRS), a resposta cardiovascular ao estresse agudo de contenção, e o tônus simpático vascular por bloqueio farmacológico (prazosina, 0,1 mg/ kg i.v). Os resultados foram analisados quanto à normalidade e variabilidade da amostragem. Diferenças entre os grupos foram analisadas utilizando o teste t Student (p<0.05). Os ratos FF mostraram um aumento significativo na PAM (FF=129,71 ± 2,0 vs CTL=117,14 ± 1,5 mmHg), e uma tendência ao aumento da FC (FF = 309,86 ± 7,1 vs CTL = 287,29 ± 8,7 bpm; p=0.067) comparado ao CTL. Como esperado, o grupo FF mostrou um prejuízo no BRS (FF = 1.11 ± 0.08 vs CTL=1.62 ± 0.08 ms/mmHg). No que se refere à resposta cardiovascular ao estresse, o grupo FF mostrou uma resposta cardiovascular exacerbada, apresentando maiores variações de PAM (FF = 37,5 ± 4,2 vs CTL = 29,0 ± 3,6 mmHg) e de FC (FF = 150,3 ± 19,5 vs CTL = 79,8 ± 20 bpm) durante e logo após o estresse. Não houve diferença quanto ao tônus simpático vascular (p> 0,05). Conclui-se que a suplementação alimentar crônica rica em frutose, além de promover aumento PAM e FC de repouso, e reduzir a sensibilidade do controle barorreflexo da FC, também contribui para uma resposta cardiovascular exacerbada ao estresse emocional moderado, conferindo a este um potencial fator de risco adicional ao desenvolvimento de doenças cardiovasculares. (FAPEAL). Palavras-chave:Estresse; Síndrome Metabólica; Sistema Nervoso Autônomo. INTRODUÇÃOA síndrome metabólica (SMet) é um conjunto de fatores de risco, tais como resistência à insulina, hiperinsulinemia, hipertrigliceridemia, arteriosclerose e hipertensão arterial, que contribuem para aumentar as chances de doenças cardiovasculares, diabetes mellitus tipo 2 e doenças renais (ABDULLA, 2011).Estudos realizados em humanos e em roedores indicam que o aumento da ingestão em longo prazo de frutose pode estar relacionada com o aparecimento de diferentes alterações cardiovasculares e metabólicas relacionadas à SMet. Esse aumento mundial na ingestão de frutose se deve principalmente a sua maior utilização na indústria alimentícia como xarope de

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Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome

Cited by 8 publications

References 39 publications

Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?

Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?

Choroidal Thickness and Volume Modifications Induced by Aerobic Exercise in Healthy Young Adults

Resposta cardiovascular ao estresse emocional agudo de ratos submetidos à suplementação alimentar rica em frutose

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