Dexamethasone and sodium carboxymethyl cellulose prevent postoperative intraperitoneal adhesions in rats

Abstract

We aimed to evaluate the effects of the barrier agent sodium carboxymethyl cellulose (SCMC) with and without dexamethasone for the prevention of postoperative adhesion formation in a rat model of postoperative peritoneal adhesion. A total of 160 three-month old male and female Wistar rats underwent a laparotomy, and adhesions were induced by ileocecal abrasion. Rats were randomly assigned to 4 groups (n=40 each): group A, untreated; group B, treated with SCMC only; group C1, treated with SCMC + 3 mg dexamethasone, and group C2, treated with SCMC + 8 mg dexamethasone. After 12 days, adhesion formation and histopathological changes were compared. In groups A, B, C1, and C2, the mortality rates were 10, 5, 5, and 5%, respectively. In groups C1 and C2, the adhesions were filmy and easy to dissect and were milder compared with those in groups A and B. The total adhesion score in group C1 (3.38±0.49) was significantly lower than that of group B (6.01±0.57; P<0.01) or group A (8.01±0.67; P<0.05). There was no significant difference in adhesion formation between groups C1 and C2. Compared with groups A and B, groups C1 and C2 exhibited milder histopathological changes. SCMC in combination with dexamethasone can prevent adhesion formation and is a better barrier agent than SCMC alone. The safety and feasibility of SCMC in combination with dexamethasone to prevent adhesion formation after abdominal surgery warrants further clinical study.

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

“…At present, even though several agents such as tadalafil,10 melatonin, and dexamethasone11,14,20 are tested in animals and proven to be effective for preventing adhesion formation/reformation, no pharmacological agents are available for humans. Therefore, numerous studies are now focused on nonpharmacological agents to prevent adhesions.…”

Enhanced Efficacy of Low-dose Lovastatin through Probiotic-Mediated Absorption: Insights from In Vitro and In Vivo Studies

“…Lovastatin and LCZ were administered once daily by intragastric gavage after being resuspended or dissolved in a 0.5 mL solution of 0.5% sodium carboxymethyl cellulose, which was prepared by dissolving 0.5 g of sodium carboxymethyl cellulose in 100 mL of sterilized saline [21]. The Ct group received an equal volume of the 0.5% sodium carboxymethyl cellulose solution.…”

Ratlarda Deneysel Olarak Oluşturulan Postoperatif Peritoneal Adezyonları Önlemede %50 Dekstrozun Rolü

“…Bu süreçlerin fizyopatolojisi aydınlatılmadan yapılacak uygulamalarda başarı şansı görece düşük olacaktır. Üstelik travma oluştuktan sonra kullanılacak madde ve yöntem ne olursa olsun, bir yandan peritoneal mezotelial hücrelere toksik etki oluşturmazken bir yandan da yara iyileşmesini hızlandırmak veya yara iyileşme süreci tamamlanana kadar mezotelial yüzeylerin birbirine adezyonunu önlemek zorunda kalacaktır (5,6). Tüm bu faktörleri bir madde/yöntemde bir araya getirmek ve optimize etmek oldukça güçtür.…”