Serum uric acid and disorders of glucose metabolism: the role of glycosuria

Andrade, Juliana Alves Manhães de; Kang, Hye Chung; Greffin, Suzana; Rosa, Maria Luiza Garcia; Lugon, Jocemir Ronaldo

doi:10.1590/1414-431x20143878

Cited by 25 publications

(22 citation statements)

References 31 publications

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“…Our result was consistent with other previous investigations. 27,[31][32][33] It is noteworthy, this finding also reinforced the previous study that showed a pathogenesis overlap among hyperuricemia and metabolic syndrome. 2 In the diagnosis of hyperuricemia, especially at higher levels, clinical suspicion of coexistent metabolic syndrome should be required.…”

Section: Discussionsupporting

confidence: 88%

Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Cross-Sectional Study in Chinese Coastal Population

Wang

Liu

et al. 2020

Metabolic Syndrome and Related Disorders

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Objective: Few studies reported the association between serum uric acid and the prevalence of metabolic syndrome in China's coastal residents. We aimed to examine the association between serum uric acid and the prevalence of metabolic syndrome as well as its components in adults and elderly from Shenzhen (a China's coastal city). Methods: We conducted a survey in a community-based household population in Shenzhen, collecting data about 4049 participants aged 20-69 years. Based on the data, we determined the prevalence of metabolic syndrome in adults and elderly with different serum uric acid concentrations. Results: According to the revised National Cholesterol Education Program Adult Treatment Panel III, the prevalence of the metabolic syndrome in the surveyed participants was 24.69% [95% confidence interval (CI): 23.4%-26.0%]. The prevalence of metabolic syndrome in participants with serum uric acid levels <4, 4-4.9, 5-5.9, 6-6.9, 7-7.9, and ‡8 mg/dL is 10.12% (95% CI: 8., respectively. Multivariable logistic regression analysis showed that participants with higher serum uric acid levels were at a higher risk of high triglycerides, low high-density lipoprotein, central obesity, high blood pressure, or high fasting glucose (P < 0.001). Conclusions: Serum uric acid levels were closely associated with metabolic syndrome and its components in Chinese coastal population.

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Section: Discussionsupporting

confidence: 88%

Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Cross-Sectional Study in Chinese Coastal Population

Wang

Liu

et al. 2020

Metabolic Syndrome and Related Disorders

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“…Some studies stated that participants who were prediabetic or diabetic but without glycosuria had a similarly elevated prevalence of hyperuricemia. In contrast, diabetic patients with glycosuria had a null prevalence of hyperuricemia and excreted more UA and Sodium than diabetic subjects without glycosuria [26]. In our study, we found that UA levels significantly reduced in both sex in an unregulated diabetic group which are speculated by losing UA with glucose ( Table 4).…”

Section: Discussionmentioning

confidence: 39%

Changing of Uric Acid Levels by Age and Sex in Patients with Diabetes Mellitus

et al. 2016

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Objective: We examined the association between uric acid and glycemic status by the aspects of age and sex. Methods:The retrospective was performed study at Okmeydanı Educate and Research Hospital. All data were obtained from the patient records. Only one sample of HbA1c or glucose measurement within a year was included. To evaluate the pattern of glucose control, we categorized the patients according to HbA1c levels and grouped them according to a range of values. HbA1c was measured by high performance liquid chromatography, routine biochemistry parameters were determined by photometric method.Results: Serum uric acid levels showed an increasing trend with the age in female group and this trend became significant after 30 years old (p<0.001). The significant effect of HbA1c and gender on uric acid levels were determined in the subjects having no renal failure. There was a significant increase of uric acid levels in prediabetics than normal group and decrease in unregulated diabetics. But in both sex groups the pattern of changing was different. Conclusion:In conclusion, we found that age is an important factor examining the serum uric acid levels of female subjects. The peak values of serum uric acid were detected in prediabetic group in males but in females this peak point was diabetic group. J Clin Exp Invest 2016; 7 (1): 1-6

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“…Consistently, in a recent prospective study including 10,802 Korean men, impaired fasting glucose (glucose 100–125 mg/dl) and diabetes mellitus were significantly associated with 13% and 53% lower risks of developing hyperuricemia, respectively, compared with those with normal fasting glucose levels after 6 years of followup . In contrast, a study showed that participants with pre–diabetes mellitus or diabetes mellitus but without glycosuria had an elevated prevalence of hyperuricemia . The findings can be explained by enhanced proximal tubule reabsorption in the early course of dysglycemia that decreases with the ensuing glycosuria at the late stage of the disorder .…”

Section: Discussionmentioning

confidence: 63%

Ideal Cardiovascular Health Metrics and Incident Hyperuricemia

Meng

Huang

et al. 2016

Arthritis Care & Research

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Objective. Hyperuricemia has been shown to be associated with increased risks of gout and cardiovascular diseases. We prospectively investigated the association between the American Heart Association (AHA) ideal cardiovascular health metrics, including smoking, body mass index, dietary intake, physical activity, blood pressure, total cholesterol, and fasting blood glucose, and the risk of developing hyperuricemia. Methods. We included 77,787 Chinese adults, ages ‡18 years (60,951 men and 16,836 women), without hyperuricemia at the baseline (2006) in this study. Information on the cardiovascular health metrics at baseline was collected. Incident hyperuricemia cases were identified by elevated serum uric acid concentrations, which were repeatedly assessed in 2006, 2008, 2010, and 2012, respectively. Cox regression was used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for incident hyperuricemia according to the baseline ideal cardiovascular health metrics. Results. We observed an inverse relation between the greater numbers of ideal cardiovascular health metrics at baseline and lower risks of developing hyperuricemia during 6 years of followup. After adjusting for age, sex, alcohol consumption, and other potential confounders, the HRs for incident hyperuricemia were 0.95, 0.84, 0.72, and 0.64 (95% CIs 0.58-0.70, P for trend < 0.0001) for participants who met 2, 3, 4, and 5-7 metrics, respectively, compared with those who met 0-1 cardiovascular health metrics. Conclusion. Greater cardiovascular health metrics were associated with lower risk of hyperuricemia in this Chinese population, suggesting that the modifiable construct defined by the AHA could be of significance in reducing the risk of developing hyperuricemia-related diseases, such as gout.

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Serum uric acid and disorders of glucose metabolism: the role of glycosuria

Cited by 25 publications

References 31 publications

Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Cross-Sectional Study in Chinese Coastal Population

Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Cross-Sectional Study in Chinese Coastal Population

Changing of Uric Acid Levels by Age and Sex in Patients with Diabetes Mellitus

Ideal Cardiovascular Health Metrics and Incident Hyperuricemia

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