Cardiorespiratory fitness, pulmonary function and C-reactive protein levels in nonsmoking individuals with diabetes

Abstract

The objective of this study was to evaluate cardiorespiratory fitness and pulmonary function and the relationship with metabolic variables and C-reactive protein (CRP) plasma levels in individuals with diabetes mellitus (DM). Nineteen men with diabetes and 19 age- and gender-matched control subjects were studied. All individuals were given incremental cardiopulmonary exercise and pulmonary function tests. In the exercise test, maximal workload (158.3±22.3 vs 135.1±25.2, P=0.005), peak heart rate (HRpeak: 149±12 vs 139±10, P=0.009), peak oxygen uptake (VO2peak: 24.2±3.2 vs 18.9±2.8, P<0.001), and anaerobic threshold (VO2VT: 14.1±3.4 vs 12.2±2.2, P=0.04) were significantly lower in individuals with diabetes than in control subjects. Pulmonary function test parameters, blood pressure, lipid profile (triglycerides, HDL, LDL, and total cholesterol), and CRP plasma levels were not different in control subjects and individuals with DM. No correlations were observed between hemoglobin A1C (HbA1c), CRP and pulmonary function test and cardiopulmonary exercise test performance. In conclusion, the results demonstrate that nonsmoking individuals with DM have decreased cardiorespiratory fitness that is not correlated with resting pulmonary function parameters, HbA1c, and CRP plasma levels.

The Relationship Between Peak Oxygen Consumption and Pulmonary Function Indices: Measured by Spirometry and Allometry Equation in Male Students

“…The result of this study shows that between FVC amount and peak oxygen consumption has a positive significant correlation. The findings from the present study are consistent with Fatemi et al [3], Rabiee et al [16] and inconsistent with Haji Nia et al [17] studies. Fatemi et al [3] reported a significant correlation among the 3 independent variables of FEV1, FVC, FEV1/FVC and projected VO 2 max values in 50 healthy males (the mean (SD) age: 22.1(2.47) years).…”

“…Fatemi et al [3] reported a significant correlation among the 3 independent variables of FEV1, FVC, FEV1/FVC and projected VO 2 max values in 50 healthy males (the mean (SD) age: 22.1(2.47) years). Rabiee et al [16] investigated the relationship between body composition and maximum oxygen consumption with pulmonary function in 20 subjects. They reported a significant positive correlation between cardiorespiratory fitness and respiratory parameters in light weight group with regard to FEV1 and FVC and heavy weight group with regard to FEV1 and FVC.…”

Cytokine profile and lymphocyte subsets in type 2 diabetes

“…Individuals with DM were medicated with metformin, gliclazide, and/or insulin for hyperglycemia, angiotensin-converting enzyme inhibitors for hypertension, and simvastatin for dyslipidemia. Exclusion criteria were smoking, anemia, alcoholism, use of anti-inflammatory drugs or inflammatory and respiratory diseases, congestive heart failure, and ischemic coronary disease ( 6 ).…”

Type 2 diabetes and reduced exercise tolerance: a review of the literature through an integrated physiology approach

“…Several studies have evaluated the cardiopulmonary performance in response to physical exercise in T2DMM subjects consistently observing, with respect to normal subjects, a reduced maximal aerobic capacity measured either in metabolic equivalents (METs) or in peak oxygen uptake (VO 2peak ) [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. This defect can be quantitatively appreciated from well-matched casecontrols studies in subjects with T2DM and no clinically evident cardiovascular disease or overt diabetic complications, consistently appearing as a 20-30% reduction in VO 2peak in both adults [18,24,25] and adolescents [26,27].…”