Association of adult weight gain and nonalcoholic fatty liver in a cross-sectional study in Wan Song Community, China

Abstract

Our objective was to examine associations of adult weight gain and nonalcoholic fatty liver disease (NAFLD). Cross-sectional interview data from 844 residents in Wan Song Community from October 2009 to April 2010 were analyzed in multivariate logistic regression models to examine odds ratios (OR) and 95% confidence intervals (CI) between NAFLD and weight change from age 20. Questionnaires, physical examinations, laboratory examinations, and ultrasonographic examination of the liver were carried out. Maximum rate of weight gain, body mass index, waist circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, fasting blood glucose, cholesterol, triglycerides, uric acid, and alanine transaminase were higher in the NAFLD group than in the control group. HDL-C in the NAFLD group was lower than in the control group. As weight gain increased (measured as the difference between current weight and weight at age 20 years), the OR of NAFLD increased in multivariate models. NAFLD OR rose with increasing weight gain as follows: OR (95%CI) for NAFLD associated with weight gain of 20+ kg compared to stable weight (change <5 kg) was 4.23 (2.49-7.09). Significantly increased NAFLD OR were observed even for weight gains of 5-9.9 kg. For the “age 20 to highest lifetime weight” metric, the OR of NAFLD also increased as weight gain increased. For the “age 20 to highest lifetime weight” metric and the “age 20 to current weight” metric, insulin resistance index (HOMA-IR) increased as weight gain increased (P<0.001). In a stepwise multivariate regression analysis, significant association was observed between adult weight gain and NAFLD (OR=1.027, 95%CI=1.002-1.055, P=0.025). We conclude that adult weight gain is strongly associated with NAFLD.

Oxy210, a novel inhibitor of hedgehog and TGF‐β signalling, ameliorates hepatic fibrosis and hypercholesterolemia in mice

“…Although the reasons for the body weight gain difference and its significance are presently unknown, given the fact that weight gain plays a detrimental role in the pathogenesis of NAFLD, and weight loss improves the condition, Oxy210‐induced reduction in weight gain may be an attractive feature of Oxy210. 37 Hepatic lipid analysis showed that unesterified cholesterol was decreased in Oxy210‐fed mice whereas triglyceride, total cholesterol, cholesterol ester and phospholipid levels were not significantly different from that of control mice (Figure 3B‐F ). Hepatic expression of LDL receptor ( Ldlr , Figure S3A ) and genes in cholesterol biosynthesis pathway ( Hmgcr , Fdft1 , Dhcf7 , Sqle , Srebf1 and Srebf2 ) was not decreased in Oxy210‐fed animals (Figure S3B‐G ).…”

The association of weight gain with nonalcoholic fatty liver disease and fibrosis detected by FibroScan in the United States

“…A previous meta-analysis demonstrated a positive association between obesity and risk of NAFLD [ 21 ]. Several studies have demonstrated an association between weight gain, NAFLD and liver fibrosis in the Asian population [ 8 , 22 , 23 ]. Another study that evaluated 88 biopsy-proven patients with NAFLD over a 1-year follow up showed fibrosis progression in those with significant weight gain, defined as more than 5 kg [ 24 ].…”

Catch‐up fat in male adults induces low testosterone and consequently promotes metabolic abnormalities and cognitive impairment

“…Total testosterone (TT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) 18,19 were measured in Subpopulation 1 using fasting blood samples.…”