Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway

Wang, Y.; Zhang, Z.Z.; Wu, Yun; Ke, Jianjuan; He, Xiang-Hu

doi:10.1590/1414-431x20133036

Cited by 68 publications

(30 citation statements)

References 40 publications

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“…Myocardial infarct size was evaluated as previously described [6]. Briefly, the ligature around the left anterior descending coronary artery was reoccluded after reperfusion.…”

Section: Determination Of Myocardial Infarct Sizementioning

confidence: 99%

Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats

Meng

Peng

Lan

2015

Cell Biochem Biophys

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Icariin, a plant-derived flavonoid, has multiple beneficial actions on the cardiovascular system. The current study investigated whether icariin postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. In in vivo rat model of myocardial ischemia/ reperfusion, we found that postconditioning with icariin significantly reduced myocardial infarct size, serum level of TNF-a and IL-10, TNF-a and IL-10 expression, and apoptosis. Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002.

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“…Myocardial infarct size was evaluated as previously described [6]. Briefly, the ligature around the left anterior descending coronary artery was reoccluded after reperfusion.…”

Section: Determination Of Myocardial Infarct Sizementioning

confidence: 99%

Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats

Meng

Peng

Lan

2015

Cell Biochem Biophys

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“…Moreover, an antiapoptotic effect of quercetin in terms of reducing caspase-3 activity has also been demonstrated in a myocardial I/R model (29) . Because quercetin was found to induce cardioprotection in the myocardial I/R model, we thought that it may also be beneficial for retinal protection in the ocular I/R model; hence, we aimed to investigate this relationship in the present study.…”

Section: Discussionmentioning

confidence: 83%

Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model

Arıkan¹,

Erşan²,

Karaca³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Purpose: This study aimed to investigate the effect of quercetin on apoptotic cell death induced by ischemia-reperfusion (I/R) injury in the rat retina. Methods: Twenty-four rats were divided into four equal groups: control, ischemic, solvent, and quercetin. I/R injury was achieved by elevating the intraocular pressure above the perfusion pressure. Intraperitoneal injections of 20 mg/kg of quercetin and dimethyl sulfoxide (DMSO) were performed in the quercetin and solvent groups, respectively, immediately prior to I/R injury, and the researchers allowed for the retinas to be reperfused. Forty-eight hours after injury, the thicknesses of the retinal ganglion cell layer (RGCL), inner nuclear layer (INL), inner plexiform layer (IPL), outer plexiform layer (OPL), and outer nuclear layer (ONL) were measured in all groups. Moreover, the numbers of terminal deoxynucleotidyl transferase dUTP nick-end-labeled [TUNEL (+)] cells and caspase-3 (+) cells in both INL and ONL were evaluated in all groups. Results: The administration of quercetin was found to reduce the thinning of all retinal layers. The mean thickness of INL in the quercetin and ischemic groups was 21 ± 5.6 µm and 16 ± 6.4 µm, respectively (P<0.05). Similarly, the mean thickness of ONL in the quercetin and ischemic groups was 50 ± 12.8 µm and 40 ± 8.7 µm, respectively (P<0.05). The antiapoptotic effect of quercetin in terms of reducing the numbers of both TUNEL (+) cells and caspase-3 (+) cells was significant in INL. The mean number of TUNEL (+) cells in INL in the ischemic and quercetin groups was 476.8 ± 45.6/mm 2 and 238.72 ± 251/mm², respectively (P<0.005). The mean number of caspase-3 (+) cells in INL of ischemic and quercetin groups was 633.6 ± 38.7/mm 2 and 342.4 ± 36.1/mm 2 , respectively (P<0.001). Conclusion:The use of quercetin may be beneficial in the treatment of retinal I/R injury because of its antiapoptotic effect on the retinal layers, particularly in INL.

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“…These concentrations are impossible to be achieved by Malbec or any red wine consumption alone [12,33]. Catechin, melatonin, and quercetin are also wine components, but the effective concentrations are at least two orders of magnitude below the active electrophysiological levels [7,12,36,[57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Antiarrhythmic mechanisms of Malbec wine and resveratrol in isolated rat heart

Nj¹,

Dj²,

Parra³

et al. 2017

Cardiovasc Disord Med

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Oxidative stress during myocardial reperfusion contributes to ventricular arrhythmias onset. We aim to evaluate the antiarrhythmic effect of Malbec wine and resveratrol and compare them with the synthetic antioxidant tiron. Since alcohol use is controversial, we also assessed dealcoholized wine.Isolated hearts from male Sprague Dawley rats were perfused with Krebs-Henseleit solution added with: Malbec wine (5 ml/L), resveratrol (10 μM,) compared to controls with alcohol (0.5 ml/L); dealcoholized wine (5 ml/L), tiron (10 mM) were compared with controls without alcohol. Epicardial action potentials were analyzed during basal state, regional ischemia and reperfusion (10 minutes each period). The incidence of arrhythmias was determined. The antioxidant effect was assessed in left ventricle homogenates and expressed as a percentage of inhibition of the ABTS•+ radical.Malbec wine and resveratrol reduced reperfusion arrhythmias in 56% and 50%, respectively, compared to 100% incidence in the control group with alcohol.Dealcoholized wine reduced arrhythmias to 50% compared to non-alcoholic control (90.5%), but tiron did not protect (69%). The free radicals inhibitory effect increased with all the compounds (resveratrol 54.2%, tiron 43.2%, Malbec wine 42.9%, dealcoholized wine 40.2%) with respect to the control groups (with alcohol 23.5%, without alcohol 21.2%). Resveratrol shortened action potential duration and prevented ischemic depolarization. Malbec prevented ischemic-induced action potential shortening.We conclude that Malbec wine and resveratrol are antiarrhythmic beyond their antioxidant properties. Alcohol content or was not essential. Protection from ischemic action potential changes could be relevant to the antiarrhythmic effect of both resveratrol and wine.

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Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway

Cited by 68 publications

References 40 publications

Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats

Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats

Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model

Antiarrhythmic mechanisms of Malbec wine and resveratrol in isolated rat heart

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