Stimulated mast cells promote maturation of myocardial microvascular endothelial cell neovessels by modulating the angiopoietin-Tie-2 signaling pathway

Wang, Z.H.; Zhu, Wei; Jiang, Tao; Zhang, Q.Y.; Wang, Meng

doi:10.1590/1414-431x20132873

Cited by 3 publications

(3 citation statements)

References 31 publications

(33 reference statements)

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“…Recently, Wang et al [ 137 ] examined the involvement of mast cells in angiogenesis in vitro by coculturing myocardial microvascular endothelial cells (MMVEC) with rat peritoneal mast cells (activated or nonactivated) or with only the granules from rat peritoneal mast cells. Mast cells activated by 48/80 induced in vitro angiogenesis, but this was not detected with nonactivated mast cells.…”

Section: Tryptases In Tumor Angiogenesismentioning

confidence: 99%

The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis

Souza

Santana

Silva

et al. 2015

BioMed Research International

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An association between mast cells and tumor angiogenesis is known to exist, but the exact role that mast cells play in this process is still unclear. It is thought that the mediators released by mast cells are important in neovascularization. However, it is not known how individual mediators are involved in this process. The major constituents of mast cell secretory granules are the mast cell specific proteases chymase, tryptase, and carboxypeptidase A3. Several previous studies aimed to understand the way in which specific mast cell granule constituents act to induce tumor angiogenesis. A body of evidence indicates that mast cell proteases are the pivotal players in inducing tumor angiogenesis. In this review, the likely mechanisms by which tryptase and chymase can act directly or indirectly to induce tumor angiogenesis are discussed. Finally, information presented here in this review indicates that mast cell proteases significantly influence angiogenesis thus affecting tumor growth and progression. This also suggests that these proteases could serve as novel therapeutic targets for the treatment of various types of cancer.

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Section: Tryptases In Tumor Angiogenesismentioning

confidence: 99%

The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis

Souza

Santana

Silva

et al. 2015

BioMed Research International

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“…We found that tryptase induced cell proliferation of human dermal microvascular endothelial cells in a dose-dependent fashion (Blair et al, 1997). We have shown elsewhere that a close correlation exists between angiogenesis and tryptase activity in MMVECs that were cocultured with MCGs directly added to MMVECs, MCGs caused a significant increase in capillary growth that could be suppressed by specific tryptase inhibitors (Wang et al, 2013).…”

Section: Discussionmentioning

confidence: 70%

Effect of oxygen and glucose deprivation on VEGF and its receptors in microvascular endothelial cells co‐cultured with mast cells

Wang

Jiang²,

Zhang³

et al. 2015

Cell Biology International

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The aim of this study was to determine the correlation between angiogenesis and the differential expression of vascular endothelial growth factor (VEGF) and its receptors in myocardial microvascular endothelial cells (MMVECs) co-cultured with mast cells (MCs) or mast cell granules (MCGs) under oxygen and glucose deprivation (OGD). MMVECs and MCs were isolated from Wistar rats. MCs spontaneously degranulated in OGD. The expression of VEGF peaked at 8 h and decreased from 16 h in OGD. However, the expression of its receptor, fms-like tyrosine kinase-1 (Flt-1), and fetal liver kinase-1 (Flk-1), decreased significantly, and angiogenic potential of MMVECs decreased in OGD. Expression of VEGF, Flt-1, and Flk-1 increased significantly when MMVECs were co-cultured with MCGs or active MCs, but MCs had only a limited ability to induce angiogenesis in OGD. The angiogenic potential of MMVECs cultured in OGD (even with MCGs) was inferior to that of MMVECs cultured under normoxic conditions. OGD have a profound effect on angiogenesis, which is more pronounced than the effect of MCs on angiogenesis.

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“…57 However, chymase activity from cardiac mast cells has also been implicated in angiogenesis in the myocardial microvasculature. 58 The down-regulation of CMA1 in females and no change in males due to ischemia might elucidate why the cardiac microvasculature has been shown to contribute to the progression of ischemic heart disease to a greater degree in females. 59…”

Section: Relative Down-regulation In Femalesmentioning

confidence: 99%

Sex differences in gene expression in response to ischemia in the human myocardium

Stone

Choi

Oliva

et al. 2018

Preprint

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Word Count: 7520 (intro-conclusion (4028) + 60 citations (1951 words)). Abstract: 254 words 2 Abstract and Keywords Background: Sex differences exist in the prevalence, presentation, and outcomes of ischemic heart disease. Females have higher risk of heart failure post myocardial infarction relative to males and the female sex is an independent risk factor for hospital and operative mortality after cardiac surgery. However, the mechanisms underlying this sexual dimorphism remain unclear.We examined sex differences in human myocardial gene expression in response to ischemia.Methods: Left ventricular biopsies from 68 male and 46 female patients undergoing aortic valve replacement surgery were obtained at baseline and after a median 74 minutes of cold cardioplegic arrest/ischemia and respective transcriptomes were quantified by RNA-Seq. Sexspecific responses to ischemia were quantified by differential gene expression, expression quantitative trait loci (eQTL) and pathway and functional analysis. Cell-type enrichment analysis. was used to obtain an estimate of the identity and relative proportions of different cell types present in each sample. Results:A sex-specific response to ischemia was observed for 271 genes. Functional annotation analysis revealed sex-specific modulation of the oxytocin signaling pathway and common pathway of fibrin clot formation. The eQTL analysis identified variant-by-sex interaction eQTLs at baseline and post-ischemia, indicative of sex differences in the genotypic effects on gene expression, and cell-type enrichment analysis showed sex-bias in proportion of specific cell types. Conclusion:In response to myocardial ischemia, the human left ventricle demonstrates changes in gene expression that differ between the sexes. These differences provide insight into the sexual dimorphism of ischemic heart disease and may aid in the development of sexspecific therapies that reduce myocardial injury.

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Stimulated mast cells promote maturation of myocardial microvascular endothelial cell neovessels by modulating the angiopoietin-Tie-2 signaling pathway

Cited by 3 publications

References 31 publications

The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis

The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis

Effect of oxygen and glucose deprivation on VEGF and its receptors in microvascular endothelial cells co‐cultured with mast cells

Sex differences in gene expression in response to ischemia in the human myocardium

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