Doença de Chagas: enfrentando a invisibilidade pela análise de histórias de vida de portadores crônicos

Pereira-Silva, Fernanda Sant’Ana; Mello, Márcio Luiz Braga Corrêa de; Araujo-Jorge, Tania C.

doi:10.1590/1413-81232022275.08492021

Cited by 7 publications

(8 citation statements)

References 19 publications

(26 reference statements)

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“…Acute Chagas disease (ACD) is an infectious disease caused by the protozoan Trypanosoma cruzi, transmitted mainly by the insect vector Triatominae, also known as "kissing bug". This endemic disease persists as one of the most neglected tropical diseases that affects 6 to 7 million people in the world, especially in the different regions of Latin America, representing a serious public health concern [1,2].…”

Section: Introductionmentioning

confidence: 99%

Health-disease Process of Acute Chagas Disease According to One Health Approach

Graça,

Quaresma

2024

ACRI

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One Health approach emerges as an innovative perspective to understand the health-disease process of acute Chagas disease (ACD). This study aimed to identify scientific evidence on the health-disease process of ACD through one health approach. This integrative literature review study had as guiding question: what is the current scientific evidence on the health-disease process of ACD according to One Health approach? A greater number of studies can be seen from 2021. The following categories were defined from the 13 studies found: One Health approach to Chagas disease; Spatial epidemiology of Chagas disease; Control and transmission factors of Chagas disease; Health indicators in Chagas disease; and Educational technology in Chagas disease. The results of this literature review, while showing greater proportions of studies involving ACD control and transmission, also demonstrate fields of study that are still little explored by national and international scientific literature, such as in the field of technologies for ACD, reflecting a large gap to be filled with future research on ACD. This study contributed to expanding the debate on the importance of an integrative approach in health research and encouraging the search for more comprehensive solutions for ACD.

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Section: Introductionmentioning

confidence: 99%

Health-disease Process of Acute Chagas Disease According to One Health Approach

Graça,

Quaresma

2024

ACRI

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“…For the most part, it affects underdeveloped countries in Latin America, corresponding to one of the seventeen most neglected tropical diseases according to the World Health Organization 1,3. Trypanosoma cruzi, the flagellated parasite that causes Chagas disease, can cause damage to the myocardium and gastrointestinal tract 8 , potentially fatal, manifesting signs and symptoms of the disease that classify the acute, indeterminate chronic and chronic phases 4,9 .…”

Section: Introductionmentioning

confidence: 99%

Epidemiological analysis of cases of acute Chagas Disease in Brazil between 2007 and 2022

Neto,

Silveira,

Oliveira

et al. 2024

JHS

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Discovered and described by researcher Carlos Chagas in 1909, Chagas disease is an infection transmissible vectorially, orally, vertically or accidentally, which represents a social and public health problem to this day. The acute phase generally occurs in children between 1 and 5 years of age, with systemic signs and symptoms such as fever, vomiting, diarrhea, anorexia, edema, lymphadenopathy, tachycardia disproportionate to fever (Faget's sign), hepatic and splenomegaly, Romaña's sign, between others. In rare cases, they manifest with myocarditis or meningoencephalitis. The indeterminate chronic phase represents 70 to 80% of cases, with patients being asymptomatic for 5 to 30 years, with normal exams or nonspecific changes, but with positive serology for Chagas. In 20 to 30% of cases, the disease progresses with manifestations of the digestive tract, such as megaesophagus or megacolon, or of the myocardium with chagasic cardiomyopathy. This is called the chronic phase of Chagas disease. The digestive form presents with odynophagia, dysphagia, malnutrition and regurgitation. The cardiac form progresses with dilated cardiomyopathy, heart failure, complex arrhythmias and risk of sudden death. Therefore, every infected individual progress to the chronic phase, whether symptomatic (cardiac and/or digestive) or undetermined (asymptomatic). And, in the Brazilian scenario, it stands out as the fourth cause of death among infectious and parasitic diseases in age groups over 45 years old. In view of the above, this work is a descriptive and retrospective epidemiological study, using secondary data on the number of confirmed cases of acute Chagas Disease in Brazil between the years 2007 and 2022, as well as the forms of infection, outcome, federative state of cases and sex of individuals affected in the same period. The information was obtained by consulting SINAN (Notifiable Diseases Information System) made available by the Information Technology Department of the Unified Health System (DATASUS), at the electronic address (http://www.datasus.gov.br).

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“…O gênero Trypanosoma é conhecido pela sua principal espécie Trypanosoma cruzi Chagas, 1909, causador da Doença de Chagas, mas que até os dias atuais apresenta determinadas dificuldades quanto ao tratamento dos doentes, principalmente os infectados em estágio crônico da doença. O perigo da parasitose é a dificuldade de detectá-la, pois caracterizase pela quase total ausência de sintomas -ou o aparecimento dos mesmos em idade avançada ou em fase aguda -e a evolução para problemas cardio-digestivos (Maslov et al, 2019;Silva et al, 2002;Pereira-Silva et al, 2022).…”

Section: Introductionunclassified