Association of parents’ physical activity and weight status with obesity and metabolic risk of their offspring

Werneck, André O.; Silva, Danilo; Silva, Ellen Caroline Mendes da; Collings, Paul J.; Ohara, David; Fernandes, Rômulo Araújo; Barbosa, Décio Sabbatini; Ronque, Ênio Ricardo Vaz; Sardinha, Luís B.; Cyrino, Edílson Serpeloni

doi:10.1590/1413-81232022272.06182021

Ciênc. saúde coletiva

2022

DOI: 10.1590/1413-81232022272.06182021

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Association of parents’ physical activity and weight status with obesity and metabolic risk of their offspring

André O. Werneck

Danilo Silva

Ellen Caroline Mendes da Silva

et al.

Abstract: Our aim was to analyze the joint association of parental characteristics and offspring obesity indicators with metabolic risk in adolescents. A cross-sectional study was carried out with 972 adolescents and their parents. We observed that overweight adolescents who have a normal weight mother show lower metabolic risk in comparison with their counterparts with overweight mothers. In conclusion, mother’s weight status moderates the relationship between offspring’ obesity indicators and metabolic risk in adolesc… Show more

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2024

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Parental obesity predisposes to exacerbated metabolic and inflammatory disturbances in childhood obesity within the framework of an altered profile of trace elements

González-Domínguez,

Jurado-Sumariva,

Domínguez-Riscart

et al. 2024

Nutr. Diabetes

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Background Family history of obesity is known to increase the odds of developing childhood obesity in the offspring, but its influence in underlying molecular complications remains unexplored. Subjects/Methods Here, we investigated a population-based cohort comprising children with obesity, with and without parental obesity (PO+, N = 20; PO−, N = 29), and lean healthy children as controls (N = 30), from whom plasma and erythrocyte samples were collected to characterize their multi-elemental profile, inflammatory status, as well as carbohydrate and lipid metabolisms. Results We found parental obesity to be associated with unhealthier outcomes in children, as reflected in increased blood insulin levels and reduced insulin sensitivity, unfavorable lipid profile, and pro-inflammatory milieu. This was accompanied by moderate alterations in the content of trace elements, including increased copper-to-zinc ratios and iron deficiency in circulation, as well as metal accumulation within erythrocytes. Conclusions Therefore, we hypothesize that family history of obesity could be an important risk factor in modulating the characteristic multi-elemental alterations behind childhood obesity, which in turn could predispose to boost related comorbidities and metabolic complications.

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Parental obesity predisposes to exacerbated metabolic and inflammatory disturbances in childhood obesity within the framework of an altered profile of trace elements

González-Domínguez,

Jurado-Sumariva,

Domínguez-Riscart

et al. 2024

Nutr. Diabetes

View full text Add to dashboard Cite

show abstract

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Association of parents’ physical activity and weight status with obesity and metabolic risk of their offspring

Cited by 1 publication

References 33 publications

Parental obesity predisposes to exacerbated metabolic and inflammatory disturbances in childhood obesity within the framework of an altered profile of trace elements

Parental obesity predisposes to exacerbated metabolic and inflammatory disturbances in childhood obesity within the framework of an altered profile of trace elements

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